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Total 34 results found since Jan 2013.
T cell control of SARS-CoV-2: When, which, and where?
Semin Immunol. 2023 Aug 29;70:101828. doi: 10.1016/j.smim.2023.101828. Online ahead of print.ABSTRACTEfficient immune protection against viruses such as SARS-CoV-2 requires the coordinated activity of innate immunity, B and T cells. Accumulating data point to a critical role for T cells not only in the clearance of established infection, but also for aborting viral replication independently of humoral immunity. Here we review the evidence supporting the contribution of antiviral T cells and consider which of their qualitative features favour efficient control of infection. We highlight how studies of SARS-CoV-2 and other c...
Source: Seminars in Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Mariana O Diniz Mala K Maini Leo Swadling Source Type: research
A roadmap for developing Venezuelan equine encephalitis virus (VEEV) vaccines: Lessons from the past, strategies for the future
Int J Biol Macromol. 2023 Jun 21:125514. doi: 10.1016/j.ijbiomac.2023.125514. Online ahead of print.ABSTRACTVenezuelan equine encephalitis (VEE) is a zoonotic infectious disease caused by the Venezuelan equine encephalitis virus (VEEV), which can lead to severe central nervous system infections in both humans and animals. At present, the medical community does not possess a viable means of addressing VEE, rendering the prevention of the virus a matter of paramount importance. Regarding the prevention and control of VEEV, the implementation of a vaccination program has been recognized as the most efficient strategy. Neverth...
Source: International Journal of Biological Macromolecules - June 23, 2023 Category: Biochemistry Authors: Lulu Han Shuai Song Huilin Feng Jing Ma Wenqiang Wei Fusheng Si Source Type: research
A vaccine for human babesiosis: prospects and feasibility
Trends Parasitol. 2022 Aug 3:S1471-4922(22)00157-X. doi: 10.1016/j.pt.2022.07.005. Online ahead of print.ABSTRACTBabesiosis is a tick-borne disease caused by intraerythrocytic Babesia parasites. It is a well-known illness in companion animals and livestock, resulting in substantial economic losses in the cattle industry. Babesiosis is also recognized as an emerging zoonosis of humans in many countries worldwide. There is no vaccine against human babesiosis. Currently, preventive measures are focused on vector avoidance. Although not always effective, treatment includes antimicrobial therapy and exchange transfusion. In thi...
Source: Trends in Parasitology - August 6, 2022 Category: Parasitology Authors: Hanan Al-Nazal Leanne Low Sanjai Kumar Michael F Good Danielle I Stanisic Source Type: research
The Macro View – Health, Economics, and Politics and the Big Picture. What I Am Watching Here And Abroad.
The objective most consistent with recent operations is to conquer Luhansk, Donetsk, and Kherson, with a view to their eventual annexation and Russification. But not only are they some way from achieving that (w ith much of Donetsk still in Ukrainian hands and the Russia position in Kherson highly contested) it would also require an explicit Ukrainian surrender for it to serve as the basis for a declaration of victory. That will not be forthcoming.-----https://www.afr.com/world/europe/how-britain-giggled-its-way-into-crisis-20220710-p5b0giHow Britain giggled its way into crisisBoris Johnson has exposed the costs of Britain...
Source: Australian Health Information Technology - July 21, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Considerations for rapid development and licencing of conventional and platform technology veterinary vaccines
Avian Pathol. 2022 Feb 24:1-11. doi: 10.1080/03079457.2022.2046703. Online ahead of print.ABSTRACTThe threat posed by zoonotic diseases and other livestock pathogens has never been greater, and thus we must do all we can to learn from past experience in order to tackle emerging disease threats. The process of developing a new veterinary vaccine involves the generation of a specific set of data in order to meet the strict product licencing requirements of regulatory approval bodies around the globe. As a result, it is important that those embarking on the development of a vaccine using either conventional or novel platform ...
Source: Avian Pathology - February 24, 2022 Category: Pathology Authors: Michael James Francis Source Type: research
