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Viral escape from NK cell-mediated immunosurveillance: A lesson for cancer immunotherapy?
This article is protected by copyright. All rights reserved.PMID:37526136 | DOI:10.1002/eji.202350465
Source: European Journal of Immunology - August 1, 2023 Category: Allergy & Immunology Authors: Pouria Momayyezi Eleni Bilev Hans-Gustaf Ljunggren Quirin Hammer Source Type: research

Malignancy-associated immune responses: Lessons from human inborn errors of immunity
Immunology. 2023 Jun 19. doi: 10.1111/imm.13675. Online ahead of print.ABSTRACTIt is widely understood that cancer is a significant cause of morbidity and mortality worldwide. Despite numerous available treatments, prognosis for many remains poor, thus, the development of novel therapies remains essential. Given the incredible success of many immunotherapies in this field, the important contribution of the immune system to the control, and elimination, of malignancy is clear. While many immunotherapies target higher-order pathways, for example, through promoting T-cell activation via immune checkpoint blockade, the potenti...
Source: Immunology - June 19, 2023 Category: Allergy & Immunology Authors: Agnel Aliyath Ayolola Eni-Olotu Niamh Donaldson Priyanka Trivedi Source Type: research

The need for change: Lessons learned from Food and Drug Administration-approved peanut oral immunotherapy
Ann Allergy Asthma Immunol. 2023 May;130(5):542-543. doi: 10.1016/j.anai.2023.01.031.NO ABSTRACTPMID:37137601 | DOI:10.1016/j.anai.2023.01.031
Source: Annals of Allergy, Asthma and Immunology - May 3, 2023 Category: Allergy & Immunology Authors: S Shahzad Mustafa Douglas P Mack Source Type: research

Future indications and clinical management for fecal microbiota transplantation (FMT) in immuno-oncology
Semin Immunol. 2023 Mar 30;67:101754. doi: 10.1016/j.smim.2023.101754. Online ahead of print.ABSTRACTThe gut microbiota has rapidly emerged as one of the "hallmarks of cancers" and a key contributor to cancer immunotherapy. Metagenomics profiling has established the link between microbiota compositions and immune checkpoint inhibitors response and toxicity, while murine experiments demonstrating the synergistic benefits of microbiota modification with immune checkpoint inhibitors (ICIs) pave a clear path for translation. Fecal microbiota transplantation (FMT) is one of the most effective treatments for patients with Clostr...
Source: Seminars in Immunology - April 1, 2023 Category: Allergy & Immunology Authors: Rahima Jamal Meriem Messaoudene Marina de Figuieredo Bertrand Routy Source Type: research

Immune Plasma for the Treatment of COVID-19: Lessons Learned so far
Hamostaseologie. 2023 Feb;43(1):67-74. doi: 10.1055/a-1987-3682. Epub 2023 Feb 20.ABSTRACTCOVID-19 convalescent plasma (CCP) has been explored as one of the treatment options for COVID-19. Results of many cohort studies and clinical trials have been recently published. At first glance, the results of the CCP studies appear to be inconsistent. However, it became clear that CCP is not beneficial if CCP with low anti-SARS-CoV-2 antibody concentrations is used, if it is administered late in advanced disease stages, and to patients who already mounted an antibody response against SARS-CoV-2 at the time of CCP transfusion. On th...
Source: Hamostaseologie - February 22, 2023 Category: Hematology Authors: Hubert Schrezenmeier Simone Hoffmann Henrike Hofmann Thomas Appl Bernd Jahrsd örfer Erhard Seifried Sixten K örper Source Type: research

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