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Specialty: Drugs & Pharmacology
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Total 27 results found since Jan 2013.

1H NMR-Based Metabolomics Reveals Refined-Huang-Lian-Jie-Du-Decoction (BBG) as a Potential Ischemic Stroke Treatment Drug With Efficacy and a Favorable Therapeutic Window
This study was carried out in accordance with the recommendations of Animal Ethics Committee of China Pharmaceutical University. The protocol was approved by Animal Ethics Committee of China Pharmaceutical University. Author Contributions JW, MY, and LK conceived the experiments and helped to coordinate support and funding. XF performed the research and drafted the manuscript. SL, YL, and DX participated in the experiments. JW analyzed the data and edited the paper. All authors read and approved the final manuscript. Conflict of Interest Statement The authors declare that the research was conducted in the absence of an...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Stroke patients ’ support: evaluation of knowledge, practices and training needs of French community pharmacists
Conclusion Based on this small study, the fragmented knowledge and varied practices promote the need for further training for pharmacists to optimize support of stroke patients. This study promotes the elaboration of training systems adapted to pharmacists ’ needs. This will help support the development of a targeted pharmaceutical care approach for stroke patients.
Source: International Journal of Clinical Pharmacy - January 2, 2021 Category: Drugs & Pharmacology Source Type: research

The effect of transcranial direct current stimulation combined with functional task training on motor recovery in stroke patients.
This article reviews the state-of-the-art of neuromodulation for stroke and discusses the opportunities and challenges available for clinicians and researchers interested in advancing neuromodulation therapy. The annual worldwide incidence of stroke ranges from 27.5 to 63 individuals per 100,000. Stroke, a major cause of adult disability, has devastating effects on patients and their caregivers, which has a tremendous socioeconomic impact on families and healthcare systems around the world. There are only a few treatments available for the improvement of motor function in stroke patients. The majority of these treatments a...
Source: European Review for Medical and Pharmacological Sciences - November 24, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

The individualized rehabilitation interventions for dysphagia: a multidisciplinary case control study of acute stroke patients.
CONCLUSION: The findings of present study showed evidence that the individualized rehabilitation interventions carried out by our multidisciplinary rehabilitation professionals provided effective therapeutic effects during the acute stroke dysphagia compared to the conventional rehabilitation interventions, which may shed light on a bright prospect of the individualized rehabilitation interventions in post-stroke dysphagic patients. PMID: 25419433 [PubMed - as supplied by publisher]
Source: International Journal of Clinical and Experimental Medicine - December 2, 2014 Category: Drugs & Pharmacology Tags: Int J Clin Exp Med Source Type: research

Neurobiology of amphetamine use in stroke recovery combined with rehabilitative training and brain stimulation
CNS Neurol Disord Drug Targets. 2022 May 12. doi: 10.2174/1871527321666220512155811. Online ahead of print.ABSTRACTStroke is a physiological disorder involving a prolonged local interruption of cerebral blood flow. It leads to massive neuronal death and causes short-term or long-lasting functional impairment. Most stroke victims regain some neural function weeks or months following a stroke, but this recovery can plateau six months or more after the injury. The goal of stroke therapy is the rehabilitation of functional capabilities, especially those affecting the patient's autonomy and quality of life. Recent clinical and ...
Source: CNS and Neurological Disorders Drug Targets - May 13, 2022 Category: Drugs & Pharmacology Authors: Mohammad Uzair Muhammad Arshad Turki Abualait Zeyad T Al-Harbi Talal M Al-Harbi Reem Bunyan Fahad Abida Arshad Woo Kyoung Yoo Shahid Bashir Source Type: research

Comparison of the effects of contralaterally controlled functional electrical stimulation and neuromuscular electrical stimulation on upper extremity functions in patients with stroke.
CONCLUSION: Compared with the conventional NMES, CCFES provides better recovery of upper extremity function in patients with stroke. PMID: 26556084 [PubMed - as supplied by publisher]
Source: CNS and Neurological Disorders Drug Targets - November 11, 2015 Category: Drugs & Pharmacology Authors: Shen Y, Yin Z, Fan Y, Chen CF, Dai W, Yi W, Li Y, Zhang W, Zhang Y, Bian R, Huang Y, Machado S, Yuan TF, Shan C Tags: CNS Neurol Disord Drug Targets Source Type: research

Effects of extended in-patient treatment training on outcome of post-stroke dysphagia.
CONCLUSIONS: The extended ward training could significantly improve the swallowing function of patients with post-stroke dysphagia, restore their swallowing function, and reduce adverse events of swallowing. The operations were simple, safe and practical. The training is worthy of promotion. PMID: 29272007 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - December 24, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Whole body vibration training improves walking performance of stroke patients with knee hyperextension: a randomized controlled pilot study.
CONCLUSION: The results suggest that 8 weeks whole body vibration training can reduce knee hyperextension and increase ambulatory speed in stroke patients. PMID: 26556074 [PubMed - as supplied by publisher]
Source: CNS and Neurological Disorders Drug Targets - November 11, 2015 Category: Drugs & Pharmacology Authors: Guo C, Mi X, Liu S, Yi W, Gong C, Zhu L, Machado S, Yuan TF, Shan C Tags: CNS Neurol Disord Drug Targets Source Type: research

Predicting 1-Hour Thrombolysis Effect of r-tPA in Patients With Acute Ischemic Stroke Using Machine Learning Algorithm
Conclusion: This study demonstrated that the GBDT model with the seven variables could better predict the early thrombolysis effect of r-tPA.
Source: Frontiers in Pharmacology - January 3, 2022 Category: Drugs & Pharmacology Source Type: research

Online training and brochure for stroke care teams launched
Source: Wessex HIEC Partnership Area: News Wessex HIEC in collaboration with the University of Central Lancashire has launched an online training package for professionals involved in stroke care. The clinical leads forum has also developed a brochure for patients and their families to understand more about the condition and information specific to their own care.   Please see link for details.
Source: NeLM - News - February 19, 2013 Category: Drugs & Pharmacology Source Type: news

The metabotropic glutamate 2/3 receptor agonist LY379268 counteracted ketamine-and apomorphine-induced performance deficits in the object recognition task, but not object location task, in rats.
Abstract Experimental evidence indicates that the non competitive N-methyl-d-aspartate (NMDA) receptor antagonist ketamine and the mixed dopamine (DA) D1/D2 receptor agonist apomorphine induce schizophrenia-like symptoms in rodents, including cognitive deficits. Activation of Group II metabotropic glutamate 2/3 (mGlu2/3) receptors reduces the excessive glutamate release that is hypothesized to be associated with psychiatric disorders. Thus, mGlu2/3 receptor agonists may reverse deficits induced by excessive glutamate or DA release induced by administration of NMDA receptor antagonists and DA receptor agonists, res...
Source: Neuropharmacology - May 20, 2014 Category: Drugs & Pharmacology Authors: Pitsikas N, Markou A Tags: Neuropharmacology Source Type: research

Mechanisms and therapeutic potential of microRNAs in hypertension.
Abstract Hypertension is the major risk factor for the development of stroke, coronary artery disease, heart failure and renal disease. The underlying cellular and molecular mechanisms of hypertension are complex and remain largely elusive. MicroRNAs (miRNAs) are short, noncoding RNA fragments of 22-26 nucleotides and regulate protein expression post-transcriptionally by targeting the 3'-untranslated region of mRNA. A growing body of recent research indicates that miRNAs are important in the pathogenesis of arterial hypertension. Herein, we summarize the current knowledge regarding the mechanisms of miRNAs in card...
Source: Drug Discovery Today - May 21, 2015 Category: Drugs & Pharmacology Authors: Shi L, Liao J, Liu B, Zeng F, Zhang L Tags: Drug Discov Today Source Type: research