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UCLA study shows how brain begins repairs after ‘silent strokes’
UCLA researchers have shown that the brain can be repaired — and brain function can be recovered — after a stroke in animals. The discovery could have important implications for treating a mind-robbing condition known as a white matter stroke, a major cause of dementia.White matter stroke is a type of ischemic stroke, in which a blood vessel carrying oxygen to the brain is blocked. Unlike large artery blockages or transient ischemic attacks, individual white matter strokes, which occur in tiny blood vessels deep within the brain, typically go unnoticed but accumulate over time. They accelerate Alzheimer ’s disease du...
Source: UCLA Newsroom: Health Sciences - December 20, 2016 Category: Universities & Medical Training Source Type: news

Low Circulating Acute Brain-Derived Neurotrophic Factor Levels Are Associated With Poor Long-Term Functional Outcome After Ischemic Stroke Brief Reports
Conclusions— Circulating concentrations of BDNF protein are lowered in the acute phase of ischemic stroke, and low levels are associated with poor long-term functional outcome. Further studies are necessary to confirm these associations and to determine the predictive value of BDNF in stroke outcomes.
Source: Stroke - June 26, 2016 Category: Neurology Authors: Stanne, T. M., Aberg, N. D., Nilsson, S., Jood, K., Blomstrand, C., Andreasson, U., Blennow, K., Zetterberg, H., Isgaard, J., Svensson, J., Jern, C. Tags: Biomarkers, Etiology, Ischemic Stroke Brief Reports Source Type: research

APE1 cKO increases postischemic injury in CNS Neuroscience
A major hallmark of oxidative DNA damage after stroke is the induction of apurinic/apyrimidinic (AP) sites and strand breaks. To mitigate cell loss after oxidative DNA damage, ischemic cells rapidly engage the base excision-repair proteins, such as the AP site-repairing enzyme AP endonuclease-1 (APE1), also named redox effector factor-1 (Ref-1)....
Source: Proceedings of the National Academy of Sciences - June 20, 2016 Category: Science Authors: Stetler, R. A., Gao, Y., Leak, R. K., Weng, Z., Shi, Y., Zhang, L., Pu, H., Zhang, F., Hu, X., Hassan, S., Ferguson, C., Homanics, G. E., Cao, G., Bennett, M. V. L., Chen, J. Tags: PNAS Plus Source Type: research

Randomized Controlled Trial Of Constraint-Induced Aphasia Therapy In Patients With Chronic Stroke (S21.001)
Conclusions: Overall, this randomized controlled trial did not show improvement in language abilities in this small group of subjects with chronic post-stroke aphasia receiving CIAT when compared to observation.Disclosure: Dr. Szaflarski has received personal compensation for activities with UCB Pharma. Dr. Szaflarski has received research support from the National Institutes of Health, the American Academy of Neurology, the Shor Foundation for Epilepsy Research, Neuren, and Eisai Inc. Dr. Allendorfer has received research support from the Shor Foundation for Epilepsy Research. Dr. Ball has nothing to disclose. Dr. Banks h...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Szaflarski, J., Allendorfer, J., Ball, A., Banks, C., Dietz, A., Hart, K., Lindsell, C., Martin, A., Vannest, J. Tags: Neuro-rehabilitation and Neural Repair Source Type: research

Brain rewires itself after damage or injury, life scientists discover
When the brain's primary "learning center" is damaged, complex new neural circuits arise to compensate for the lost function, say life scientists from UCLA and Australia who have pinpointed the regions of the brain involved in creating those alternate pathways — often far from the damaged site.   The research, conducted by UCLA's Michael Fanselow and Moriel Zelikowsky in collaboration with Bryce Vissel, a group leader of the neuroscience research program at Sydney's Garvan Institute of Medical Research, appears this week in the early online edition of the journal Proceedings of the National Academy of Sciences. ...
Source: UCLA Newsroom: Health Sciences - May 15, 2013 Category: Universities & Medical Training Source Type: news

Boosting 'cellular garbage disposal' can delay the aging process, UCLA biologists report
UCLA life scientists have identified a gene previously implicated in Parkinson's disease that can delay the onset of aging and extend the healthy life span of fruit flies. The research, they say, could have important implications for aging and disease in humans.   The gene, called parkin, serves at least two vital functions: It marks damaged proteins so that cells can discard them before they become toxic, and it is believed to play a key role in the removal of damaged mitochondria from cells.   "Aging is a major risk factor for the development and progression of many neurodegenerative diseases," said David Walke...
Source: UCLA Newsroom: Health Sciences - May 6, 2013 Category: Universities & Medical Training Source Type: news

In Stroke And Other Neurological Disorders, Nitric Oxide Damages Neurons And Blocks The Brain's Ability To Repair Itself
Nitric oxide, a gaseous molecule produced in the brain, can damage neurons. When the brain produces too much nitric oxide, it contributes to the severity and progression of stroke and neurodegenerative diseases such as Alzheimer's. Researchers at Sanford-Burnham Medical Research Institute recently discovered that nitric oxide not only damages neurons, it also shuts down the brain's repair mechanisms. Their study was published by the Proceedings of the National Academy of Sciences the week of February 4...
Source: Health News from Medical News Today - February 7, 2013 Category: Consumer Health News Tags: Stroke Source Type: news

Chemical reaction keeps stroke-damaged brain from repairing itself
(Sanford-Burnham Medical Research Institute) Nitric oxide, a gaseous molecule produced in the brain, can damage neurons. When the brain produces too much nitric oxide, it contributes to the severity and progression of stroke and neurodegenerative diseases such as Alzheimer's. Researchers at Sanford-Burnham Medical Research Institute recently discovered that nitric oxide not only damages neurons, it also shuts down the brain's repair mechanisms. Their study was published Feb. 4 by the Proceedings of the National Academy of Sciences.
Source: EurekAlert! - Medicine and Health - February 4, 2013 Category: Global & Universal Source Type: news

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