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Specialty: Molecular Biology
Education: Grants

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Total 135 results found since Jan 2013.

Prevalence of ATTR-CA and high-risk features to guide testing in patients referred for TAVR
CONCLUSION: The prevalence of ATTR-CA may be lower in a contemporary TAVR population due to its expanded indication for low-risk patients. NT-pro BNP is a simple test that can improve screening yield and more judiciously guide screening for ATTR-CA in this at-risk population. Comparison of the original versus the proposed algorithm.PMID:37606857 | DOI:10.1007/s00259-023-06374-2
Source: Molecular Medicine - August 22, 2023 Category: Molecular Biology Authors: Bryan Abadie Adel Hajj Ali Trejeeve Martyn Andrew Higgins Amar Krishnaswamy Grant Reed Rishi Puri James Yun Paul Cremer Mazen Hanna W H Wilson Tang Samir Kapadia Wael Jaber Source Type: research

Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2
We describe the structural mechanism for targeting of BIRC2BIR3 by a potent but biochemically uncharacterized small molecule inhibitor LCL161 and demonstrate that LCL161 disrupts the association of endogenous BIRC2 with H3 and stimulates cell death in cancer cells. We further show that LCL161 mediates degradation of BIRC2 in human immunodeficiency virus type 1-infected human CD4+ T cells. Our findings provide mechanistic insights into the nuclear accumulation of and blocking BIRC2.PMID:37524969 | DOI:10.1038/s41594-023-01044-1
Source: Mol Biol Cell - July 31, 2023 Category: Molecular Biology Authors: Adam H Tencer Yucong Yu Sebastien Z Causse Grant R Campbell Brianna J Klein Hongwen Xuan Jessy Cartier Mark A Miles Nitika Gaurav Aymeric Zadoroznyj Tina A Holt Hong Wen Christine J Hawkins Stephen A Spector Laurence Dubrez Xiaobing Shi Tatiana G Kutatela Source Type: research

PhosphoDisco: a toolkit for co-regulated phosphorylation module discovery in phosphoproteomic data
Mol Cell Proteomics. 2023 Jun 30:100596. doi: 10.1016/j.mcpro.2023.100596. Online ahead of print.ABSTRACTKinases are key players in cancer-relevant pathways and are the targets of many successful precision cancer therapies (1, 2). Phosphoproteomics is a powerful approach to study kinase activity and has been used increasingly for the characterization of tumor samples leading to the identification of novel chemotherapeutic targets and biomarkers (3-10). Finding co-regulated phosphorylation sites which represent potential kinase-substrate sets or members of the same signaling pathway allows us to harness this data to identif...
Source: Molecular and Cellular Proteomics : MCP - July 2, 2023 Category: Molecular Biology Authors: Tobias Schraink Lili Blumenberg Grant Hussey Sabrina George Brecca Miller Nithu Mathew Tania J Gonz ález-Robles Vladislav Sviderskiy Thales Papagiannakopoulos Richard Possemato David Feny ö Kelly V Ruggles Source Type: research

H4K16ac activates the transcription of transposable elements and contributes to their cis-regulatory function
Nat Struct Mol Biol. 2023 Jun 12. doi: 10.1038/s41594-023-01016-5. Online ahead of print.ABSTRACTMammalian genomes harbor abundant transposable elements (TEs) and their remnants, with numerous epigenetic repression mechanisms enacted to silence TE transcription. However, TEs are upregulated during early development, neuronal lineage, and cancers, although the epigenetic factors contributing to the transcription of TEs have yet to be fully elucidated. Here, we demonstrate that the male-specific lethal (MSL)-complex-mediated histone H4 acetylation at lysine 16 (H4K16ac) is enriched at TEs in human embryonic stem cells (hESCs...
Source: Mol Biol Cell - June 12, 2023 Category: Molecular Biology Authors: Debosree Pal Manthan Patel Fanny Boulet Jayakumar Sundarraj Olivia A Grant Miguel R Branco Srinjan Basu Silvia D M Santos Nicolae Radu Zabet Paola Scaffidi Madapura M Pradeepa Source Type: research

Maternal diet and gut microbiome composition modulate early-life immune development
EMBO Mol Med. 2023 Jun 6:e17241. doi: 10.15252/emmm.202217241. Online ahead of print.ABSTRACTIn early life, the intestinal mucosa and immune system undergo a critical developmental process to contain the expanding gut microbiome while promoting tolerance toward commensals, yet the influence of maternal diet and microbial composition on offspring immune maturation remains poorly understood. We colonized germ-free mice with a consortium of 14 strains, fed them a standard fiber-rich chow or a fiber-free diet, and then longitudinally assessed offspring development during the weaning period. Unlike pups born to dams fed the fib...
Source: Molecular Medicine - June 6, 2023 Category: Molecular Biology Authors: Erica T Grant Marie Boudaud Arnaud Muller Andrew J Macpherson Mahesh S Desai Source Type: research

Challenges and opportunities in maintaining research momentum at a primarily undergraduate institution
Mol Biol Cell. 2023 Jun 1;34(7):vo2. doi: 10.1091/mbc.E23-01-0026.ABSTRACTConferences and meetings hosted by scientific societies usually include sessions on how to navigate the academic faculty job search and the initial setup of a laboratory, or how to identify and pursue early-career grant funding opportunities. However, there is not much professional development support available beyond this stage. Faculty may have set up the research lab and have recruited students to their groups but then might find themselves struggling to be successful in accomplishing their goals. In other words, how can we maintain the momentum o...
Source: Mol Biol Cell - May 19, 2023 Category: Molecular Biology Authors: Mariana Torrente Ozlem Dilek Source Type: research

The under-appreciated world of the serpin family of serine proteinase inhibitors
EMBO Mol Med. 2023 May 9:e17144. doi: 10.15252/emmm.202217144. Online ahead of print.ABSTRACTIn the practice of medicine, many fundamental biological pathways that require tight on/off control, such as inflammation and circulatory homeostasis, are regulated by serine proteinases, but we rarely consider the unique protease inhibitors that, in turn, regulate these proteases. The serpins are a family of proteins with a shared tertiary structure, whose members largely act as serine protease inhibitors, found in all forms of life, ranging from viruses, bacteria, and archaea to plants and animals. These proteins represent up to ...
Source: Molecular Medicine - May 9, 2023 Category: Molecular Biology Authors: Marie-Christine Bouton Margarethe Geiger William P Sheffield James A Irving David A Lomas Sihong Song Ritvik S Satyanarayanan Liqiang Zhang Grant McFadden Alexandra R Lucas Source Type: research

The current situations and limitations of genetic engineering in cyanobacteria: a mini review
Mol Biol Rep. 2023 Apr 29. doi: 10.1007/s11033-023-08456-8. Online ahead of print.ABSTRACTCyanobacteria are an ancient group of photoautotrophic prokaryotes, and play an essential role in the global carbon cycle. They are also model organisms for studying photosynthesis and circadian regulation, and metabolic engineering and synthetic biology strategies grants light-driven biotechnological applications to cyanobacteria, especially for engineering cyanobacteria cells to achieve an efficient light-driven system for synthesizing any product of interest from renewable feedstocks. However, lower yield limits the potential of in...
Source: Molecular Biology Reports - April 29, 2023 Category: Molecular Biology Authors: Jie Cheng Kaidian Zhang Yuyong Hou Source Type: research