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Ability to Suppress TGF- β-Activated Myofibroblast Differentiation Distinguishes the Anti-pulmonary Fibrosis Efficacy of Two Danshen-Containing Chinese Herbal Medicine Prescriptions
Conclusion: This study suggests that a clinically efficacious cardiovascular Chinese herbal medicine (DLP) can be successfully repurposed to treat a lung disease in pulmonary fibrosis guided by TCM theory. Our comparative study between DLP and DHP demonstrated a critical requirement of suppressing both pro-inflammatory and pro-fibrotic pathways for the treatment of pulmonary fibrosis, supporting that a multi-component prescription capable of “removing both phlegm and blood stasis” will better achieve co-protection of heart and lung in PHD. Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic ...
Source: Frontiers in Pharmacology - April 23, 2019 Category: Drugs & Pharmacology Source Type: research

Asymptomatic Carotid Stenosis Is Associated With Circadian and Other Variability in Embolus Detection
Conclusions: Embolism associated with asymptomatic carotid stenosis shows circadian variation with highest rates 4–6 h before midday. This corresponds with peak circadian incidence of stroke and other vascular complications. These and ASED Study results show that monitoring frequency, duration, and time of day are important in ES detection. Introduction Transcranial Doppler (TCD) detected microembolism in the ipsilateral middle cerebral artery (MCA) may help stratify the risk of stroke and other arterial disease complications in persons with advanced (≥60%) asymptomatic carotid stenosis. If so, this t...
Source: Frontiers in Neurology - April 15, 2019 Category: Neurology Source Type: research

High Rate of Stenosis Progression Identified with Routine Carotid Doppler Surveillance (P5.284)
Conclusions:Among this prospective cohort of asymptomatic ≥50% carotid stenosis subjects followed with carotid Doppler imaging, high rates of carotid stenosis progression occurred despite contemporary intensive medical management, and significant TIA/stroke rates were also noted, especially among those with ≥80% stenosis. These results support further study of routine carotid Doppler surveillance in management of asymptomatic carotid stenosis.Study Supported by:Grants from the American Heart Association (15GRNT25270010), NIH (1 U54GM104938) and the VA Clinical Science Research & Development Service (CX000340)Disc...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Kirkpatrick, A., Stoner, J., Tafur, A., Elias, A., Prodan, C. Tags: SubAcute Interventional Therapies in Cerebrovascular Disease Source Type: research