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Infectious Disease: Parasitic Diseases
Education: Grants
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Total 72 results found since Jan 2013.
Development of CRISPR/Cas13a-based assays for the diagnosis of Schistosomiasis
EBioMedicine. 2023 Jul 22;94:104730. doi: 10.1016/j.ebiom.2023.104730. Online ahead of print.ABSTRACTBACKGROUND: Schistosomiasis is a disease that significantly impacts human health in the developing world. Effective diagnostics are urgently needed for improved control of this disease. CRISPR-based technology has rapidly accelerated the development of a revolutionary and powerful diagnostics platform, resulting in the advancement of a class of ultrasensitive, specific, cost-effective and portable diagnostics, typified by applications in COVID-19/cancer diagnosis.METHODS: We developed CRISPR-based diagnostic platform SHERLO...
Source: Cancer Control - July 24, 2023 Category: Cancer & Oncology Authors: Skye R MacGregor Donald P McManus Haran Sivakumaran Thomas G Egwang Moses Adriko Pengfei Cai Catherine A Gordon Mary G Duke Juliet D French Natasha Collinson Remigio M Olveda Gunter Hartel Carlos Graeff-Teixeira Malcolm K Jones Hong You Source Type: research
Environmental DNA/RNA for pathogen and parasite detection, surveillance, and ecology
Trends Parasitol. 2023 Feb 7:S1471-4922(22)00315-4. doi: 10.1016/j.pt.2022.12.010. Online ahead of print.ABSTRACTDetection of pathogens, parasites, and other symbionts in environmental samples via eDNA/eRNA (collectively eNA) is an increasingly important source of information about their occurrence and activity. There is great potential for using such detections as a proxy for infection of host organisms in connected habitats, for pathogen monitoring and surveillance, and for early warning systems for disease. However, many factors require consideration, and appropriate methods developed and verified, in order that eNA det...
Source: Trends in Parasitology - February 9, 2023 Category: Parasitology Authors: David Bass Kevin W Christison Grant D Stentiford Lauren S J Cook Hanna Hartikainen Source Type: research
Asia-Pacific International Center of Excellence in Malaria Research: Maximizing Impact on Malaria Control Policy and Public Health in Cambodia and Papua New Guinea
Am J Trop Med Hyg. 2022 Oct 11;107(4_Suppl):124-130. doi: 10.4269/ajtmh.21-1324. Print 2022 Oct 11.ABSTRACTThe Asia-Pacific International Center of Excellence in Malaria Research (ICEMR) was funded in 2016 to conduct a coordinated set of field and in-depth biological studies in Cambodia and Papua New Guinea (PNG), in sites that span the range of transmission intensities currently found in the Asia-Pacific regions. The overall objective is to gain an understanding of key parasite, human host, and vector factors involved in maintaining transmission in the face of intensified control and elimination programs, and to develop n...
Source: Am J Trop Med Hyg - October 13, 2022 Category: Infectious Diseases Authors: Leanne J Robinson Moses Laman Leo Makita Dysoley Lek Annie Dori Rachael Farquhar Amelie Vantaux Benoit Witkowski Stephan Karl Ivo Mueller Source Type: research
Simulating the Impacts of Augmenting Intensive Vector Control with Mass Drug Administration or Test-and-Treat Strategies on the Malaria Infectious Reservoir
Am J Trop Med Hyg. 2022 Oct 3:tpmd210953. doi: 10.4269/ajtmh.21-0953. Online ahead of print.ABSTRACTHighly effective vector control can reduce malaria burden significantly, but individuals with parasitemia provide a potential reservoir for onward transmission. We performed an empirical, non-parametric simulation based on cohort data from Tororo District, Uganda-an area with historically high but recently reduced malaria transmission-to estimate the effects of mass drug administration (MDA) and test-and-treat on parasite prevalence. We estimate that a single round of MDA would have accelerated declines in parasite prevalenc...
Source: The American Journal of Tropical Medicine and Hygiene - October 3, 2022 Category: Tropical Medicine Authors: Joaniter I Nankabirwa Emmanuel Arinaitwe Jessica Briggs John Rek Philip J Rosenthal Moses R Kamya Peter Olwoch David L Smith Isabel Rodriguez-Barraquer Grant Dorsey Bryan Greenhouse Source Type: research
