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Specialty: Drugs & Pharmacology
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Total 425 results found since Jan 2013.
Ethical Requirements for Human Challenge Studies: A Systematic Review of Reasons
Clin Pharmacol Ther. 2023 Sep 16. doi: 10.1002/cpt.3054. Online ahead of print.ABSTRACTHuman challenge studies (HCS) are controlled clinical trials in which participants are deliberately infected with a pathogen. Such trials are being developed for an increasing number of diseases. Partly as a result of the COVID-19 pandemic, there has been a recent ethical debate about the reasons for and against HCS in general, or rather, about the requirements that individual HCS must fulfill to be ethically acceptable. A systematic review was conducted to categorize and summarize such requirements and the reasons given for them. Ethics...
Source: Clinical Pharmacology and Therapeutics - September 16, 2023 Category: Drugs & Pharmacology Authors: Matthias Katzer Sabine Salloch Christoph Schindler Marcel Mertz Source Type: research
Oteseconazole for the Treatment of Recurrent Vulvovaginal Candidiasis: A Drug Review
CONCLUSIONS: Oteseconazole is an effective and safe treatment option for the management of RVVC though current research lacks comparison with established maintenance regimens. Additional research is needed to ascertain the placement of oteseconazole in the treatment of RVVC.PMID:37650387 | DOI:10.1177/10600280231195649
Source: The Annals of Pharmacotherapy - August 31, 2023 Category: Drugs & Pharmacology Authors: Cameron Lanier Tyler C Melton Source Type: research
How to Deprescribe Potentially Inappropriate Medications During the Hospital-to-Home Transition: Stakeholder Perspectives on Essential Tasks
The objective of this study was to gather perspectives from patient, practitioner, and HHC clinician stakeholders on tasks that are essential to postacute deprescribing in HHC.METHODS: A total of 44 stakeholders, including 14 HHC patients, 15 practitioners (including 9 primary care physicians, 4 pharmacists, 1 hospitalist, and 1 nurse practitioner), and 15 HHC nurses, participated. The stakeholders were from 12 US states, including New York (n = 29), Colorado (n = 2), Connecticut (n = 1), Illinois (n = 2), Kansas (n = 2), Massachusetts (n = 1), Minnesota (n = 1), Mississippi (n = 1), Nebraska (n = 1), Ohio (n = 1), Tenness...
Source: Clinical Therapeutics - August 28, 2023 Category: Drugs & Pharmacology Authors: Jinjiao Wang Jenny Y Shen Fang Yu Kobi Nathan Thomas V Caprio Yeates Conwell Marian S Moskow Judith D Brasch Sandra F Simmons Amanda S Mixon Sally A Norton Source Type: research
Healthcare Professional (HCP) and Patient Usability Evaluation and Preferences of Two Auto-injector Devices for Self-Injection of Biosimilars, SB4 and SB5: A Literature Review
ConclusionThe analyzed data on usability and device preference indicate that SB4/Pen and SB5/Pen were preferred over the other reference product autoinjectors, thanks to their button-free design, auditory and visual injection feedback, and overall ease of use. Therefore, they were preferred over the other reference product autoinjectors. Because user-friendly devices can improve treatment adherence, pharmaceutical companies should consider patient convenience when developing medical devices.
Source: Clinical Drug Investigation - August 24, 2023 Category: Drugs & Pharmacology Source Type: research
Broadening access to tenofovir alafenamide for the treatment and prevention of HIV-1 infection
Expert Rev Clin Pharmacol. 2023 Aug 23. doi: 10.1080/17512433.2023.2251387. Online ahead of print.ABSTRACTINTRODUCTION: Tenofovir alafenamide (TAF), a prodrug of tenofovir achieves higher intracellular concentrations of tenofovir-diphosphate and 90% lower plasma concentrations of tenofovir compared to tenofovir disoproxil fumarate (TDF). TAF is associated with improved renal and bone safety outcomes.AREAS COVERED: We review the efficacy and safety of TAF-containing regimens in adults and pediatrics. We highlight safety data during pregnancy, drug interactions during co-administration with tuberculosis treatment, and critic...
Source: Pharmacological Reviews - August 23, 2023 Category: Drugs & Pharmacology Authors: Emmanuella Chinonso Osuala Anushka Naidoo Kelly E Dooley Kogieleum Naidoo Rubeshan Perumal Source Type: research
