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Association of Stroke and Cerebrovascular Pathologies With Scam Susceptibility in Older Adults
CONCLUSIONS AND RELEVANCE: Cerebrovascular pathologies, specifically cerebral infarcts, is linked with greater scam susceptibility in older adults, independent of common neurodegenerative diseases such as Alzheimer disease. Future studies examining in vivo magnetic resonance imaging markers of cerebrovascular pathologies with scam susceptibility and related decision-making outcomes will be important.PMID:36315115 | DOI:10.1001/jamaneurol.2022.3711
Source: Atherosclerosis - October 31, 2022 Category: Cardiology Authors: Alifiya Kapasi Julie A Schneider Lei Yu Melissa Lamar David A Bennett Patricia A Boyle Source Type: research

Association of ankle-brachial index with cognitive decline in patients with lacunar infarction
This study aimed to investigate the relationship of ankle-brachial pressure index (ABI) and brachial-ankle pulse wave velocity (baPWV) with cognitive function in patients with lacunar infarction. We included records of consecutive patients with their first-ever acute stroke and a diagnosis of lacunar infarction through magnetic resonance imaging (MRI) from July 1, 2011 to December 31, 2018. We excluded patients diagnosed with dementia, including strategic single-infarct dementia, before or after stroke onset. Moreover, we excluded patients with one or more microbleeds, severe white matter lesions, or severe medial temporal...
Source: Atherosclerosis - February 4, 2022 Category: Cardiology Authors: Masahiro Nakamori Hayato Matsushima Keisuke Tachiyama Yuki Hayashi Eiji Imamura Tatsuya Mizoue Shinichi Wakabayashi Source Type: research

Elevated Aortic Pulse Wave Velocity Relates to Longitudinal Gray and White Matter Changes
CONCLUSIONS: In older adults, higher baseline aortic PWV related to greater decrease in gray matter volume and greater increase in WMHs over time. Because of unmet cerebral metabolic demands and microvascular remodeling, arterial stiffening may preferentially affect certain highly active brain regions like the temporal lobes. These same regions are affected early in the course of Alzheimer disease.PMID:34706559 | DOI:10.1161/ATVBAHA.121.316477
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 28, 2021 Category: Cardiology Authors: Corey W Bown Omair A Khan Elizabeth E Moore Dandan Liu Kimberly R Pechman Francis E Cambronero James G Terry Sangeeta Nair L Taylor Davis Katherine A Gifford Bennett A Landman Timothy J Hohman John Jeffrey Carr Angela L Jefferson Source Type: research

Compensatory functional reorganization may precede hypertension-related brain damage and cognitive decline: a functional magnetic resonance imaging study
This article reports the results of functional MRI during a Stroop color interference task and structural evaluations based on a modified Fazekas scale. Results: No intergroup differences were found in regards to the severity of white matter lesions (Mann–Whitney U test = 150.5, P > 0.1), nor from the task performance in the scanner (t(35) = 0.2, P > 0.1). However, brain activation patterns between patients and controls varied. Hypertensive patients involved significantly more cerebral areas during the processing, regardless of the task difficulty. Differences were found in 26 diverse regions of both pri...
Source: Journal of Hypertension - April 26, 2017 Category: Cardiology Tags: ORIGINAL PAPERS: Stroke and cognitive decline Source Type: research

Rationale and design of AXAFA-AFNET 5: an investigator-initiated, randomized, open, blinded outcome assessment, multi-centre trial to comparing continuous apixaban to vitamin K antagonists in patients undergoing atrial fibrillation catheter ablation
Conclusion</div>The results of AXAFA-AFNET 5 will provide evidence informing about the safety of apixaban in ablation patients and on its efficacy including effects on silent brain lesions. AXAFA – AFNET 5 is an investigator-initiated trial sponsored by AFNET. The trial is supported by the DZHK (German Centre for Cardiovascular Research) and by the BMBF (German Ministry of Education and Research) and by Bristol-Myers Squibb/Pfizer Alliance.</span>
Source: Europace - October 13, 2016 Category: Cardiology Source Type: research