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Factors Associated with Antiretroviral Therapy Adherence Among a Community-Based Sample of Sexual Minority Older Adults with HIV
This study utilized a stochastic search variable selection (SVSS) approach to explore potential psychosocial and structural factors associated with HIV-related health outcomes among a community-based sample of older sexual minorities (N  = 150) in South Florida, an U.S. HIV-epidemic epicenter. After SVSS, a forward entry regression approach suggested unstable housing, illicit substance use, current nicotine use, and depression were all associated with poorer ART adherence among older sexual minority adults living with HIV. No a ssociations between potential correlates and biological measures of HIV disease severity wer...
Source: AIDS and Behavior - September 23, 2023 Category: Infectious Diseases Source Type: research

Electronic Cigarette Exposure Disrupts Airway Epithelial Barrier Function and Exacerbates Viral Infection
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 12. doi: 10.1152/ajplung.00135.2023. Online ahead of print.ABSTRACTThe use of electronic cigarettes (e-cigs), especially among teenagers, has reached alarming and epidemic levels, posing a significant threat to public health. However, the short- and long-term effects of vaping on the airway epithelial barrier are unclear. Airway epithelial cells are the forefront protectors from viruses and pathogens. They contain apical junctional complexes (AJC), which include tight junctions (TJs) and adherens junctions (AJs) formed between adjacent cells. Previously, we reported respiratory ...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - September 12, 2023 Category: Cytology Authors: Andjela Raduka Nannan Gao Robert L Chatburn Fariba Rezaee Source Type: research

Nicotine exacerbates diabetic nephropathy through upregulation of Grem1 expression
CONCLUSION: Grem1 plays a vital role in nicotine-exacerbated DN. Grem1 may be a potential therapeutic target for chronic smokers with DN.PMID:37415117 | DOI:10.1186/s10020-023-00692-9
Source: Molecular Medicine - July 6, 2023 Category: Molecular Biology Authors: Jianning Chen Haiting Xiao Rui Xue Vinod Kumar Rukhsana Aslam Syed Faizan Mehdi Huairong Luo Ashwani Malhotra Xiqian Lan Pravin Singhal Source Type: research

Fraction of Free-Base Nicotine in Simulated Vaping Aerosol Particles Determined by X-ray Spectroscopies
J Phys Chem Lett. 2023 Jan 31:1279-1287. doi: 10.1021/acs.jpclett.2c03748. Online ahead of print.ABSTRACTA new generation of electronic cigarettes is exacerbating the youth vaping epidemic by incorporating additives that increase the acidity of generated aerosols, which facilitate uptake of high nicotine levels. We need to better understand the chemical speciation of vaping aerosols to assess the impact of acidification. Here we used X-ray photoelectron spectroscopy (XPS) and near-edge X-ray absorption fine structure (NEXAFS) spectroscopy to probe the acid-base equilibria of nicotine in hydrated vaping aerosols. We show th...
Source: Health Physics - January 31, 2023 Category: Physics Authors: Chaya Weeraratna Xiaochen Tang Oleg Kostko Vi H Rapp Lara A Gundel Hugo Destaillats Musahid Ahmed Source Type: research

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