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Total 173 results found since Jan 2013.
Creating a sustainable rural general surgery workforce: what enables fellows to return as rural general surgeons?
CONCLUSION: Ensuring a sustainable general surgical workforce in a rural community requires employee and surgical leadership to ensure a collaborative and progressive culture, which offers work diversity, supports the family lifestyle and petitions for selecting those who embody the rural general surgeon identity. Post-fellowship positions can enable young general surgeons to have exposure to the realities of a rural lifestyle, which is likely to have a positive effect on recruitment. Due to the return investment of the fellowship program, we propose that the federal government should look at funding post-fellowship positi...
Source: Rural Remote Health - August 25, 2023 Category: Rural Health Authors: Jessica A Paynter Kirby R Qin Christine Cuthbertson Janelle Brennan Source Type: research
Varenicline enhances recognition memory via α7 nicotinic acetylcholine receptors in the medial prefrontal cortex in male mice
Neuropharmacology. 2023 Jul 26:109672. doi: 10.1016/j.neuropharm.2023.109672. Online ahead of print.ABSTRACTPrevious studies postulated that chronic administration of varenicline, a partial and full agonist at α4β2 and α7 nicotinic acetylcholine receptors (nAChRs), respectively, enhances recognition memory. However, whether its acute administration is effective, on which brain region(s) it acts, and in what signaling it is involved, remain unknown. To address these issues, we conducted a novel object recognition test using male C57BL/6J mice, focusing on the medial prefrontal cortex (mPFC), a brain region associated wit...
Source: Neuropharmacology - July 28, 2023 Category: Drugs & Pharmacology Authors: Hirohito Esaki Satoshi Deyama Shoma Izumi Ayano Katsura Keisuke Nishikawa Naoya Nishitani Katsuyuki Kaneda Source Type: research
Targeting beta-catenin signaling for prevention of colorectal cancer - Nutraceutical, drug, and dietary options
Eur J Pharmacol. 2023 Jul 20:175898. doi: 10.1016/j.ejphar.2023.175898. Online ahead of print.ABSTRACTProgressive up-regulation of β-catenin signaling is very common in the transformation of colorectal epithelium to colorectal cancer (CRC). Practical measures for opposing such signaling hence have potential for preventing or slowing such transformation. cAMP/PKA activity in colon epithelium, as stimulated by COX-2-generated prostaglandins and β2-adrenergic signaling, boosts β-catenin activity, whereas cGMP/PKG signaling has the opposite effect. Bacterial generation of short-chain fatty acids (as supported by unrefined h...
Source: European Journal of Pharmacology - July 22, 2023 Category: Drugs & Pharmacology Authors: Simon Bernard Iloki Assanga Lidianys Mar ía Lewis Luján Mark F McCarty Source Type: research
Surgical residents as "second victims" following exposure to medical errors in a tertiary health training facility in Nigeria: a phenomenology study
CONCLUSION: The "second victim" phenomenon was common among the study group with consequent negative effects. Normalizing discussions about medical errors, reduction of work hours and meticulous intraoperative guidance may reduce medical errors and its consequences on the surgical residents. Steps should be taken within the system to address this issue effectively.PMID:37464356 | DOI:10.1186/s13037-023-00370-z
Source: Patient Safety in Surgery - July 18, 2023 Category: Surgery Authors: James Ayokunle Balogun Adefisayo Ayoade Adekanmbi Folusho Mubowale Balogun Source Type: research
Estimating the Cost of Delivering Tobacco Cessation Intervention Package at Non-Communicable Disease Clinics in Two Districts of North India
CONCLUSION: The development costs of the intervention package accounted for the majority proportion of the total cost. Of the total unit cost of implementation, the telephonic follow-up, human resources, and capital resources were the major contributory components.IMPLICATIONS: The current study aims to fill gaps by estimating the unit-level health systems cost of a culturally sensitive, disease-specific, and patient-centric tobacco cessation intervention package delivered at the outpatient settings of NCD clinics at the secondary level hospital, which represents a major link in the health care system of India. Findings fr...
Source: Cancer Control - July 4, 2023 Category: Cancer & Oncology Authors: Garima Bhatt Sonu Goel Tanvi Kira Sandeep Grover Bikash Medhi Gurmandeep Singh Sandeep Singh Gill Source Type: research
Endurance exercise training attenuates the waterpipe smoke inhaling-induced learning and memory impairment in Rats: Role of neurotrophic factors and apoptotic system
CONCLUSION: Findings suggest that moderate-intensity endurance exercise training can ameliorate learning and memory impairment caused by waterpipe smoke in rats. This effect partly results from increasing the expression of neurotrophic factors BDNF and IGF-1 and correcting pro/anti-apoptotic proteins balance in the hippocampal tissue.IMPLICATIONS: Popularity of waterpipe tobacco smoking especially in youth is increasing. We assessed the effect of hookah smoke with/without exercise on learning and memory. Hookah smoke leads to CA1-neural injury and impairs learning and memory in rats. A combination of exercise training with...
Source: Cell Research - June 22, 2023 Category: Cytology Authors: Mohsen Taghipour Siyavash Joukar Samaneh Sadat Alavi Fatemeh Mohammadi Majid Asadi-Shekari Zahra Alibolandi Source Type: research
Career Conversations: Q & A With Physiologist Elimelda Moige Ongeri
Credit: Courtesy of Dr. Elimelda Moige Ongeri.
A career path in science is rarely clear cut and linear, which Elimelda Moige Ongeri, Ph.D., can attest adds to its excitement. She went from working in animal reproductive biology to studying proteins involved in inflammation and tissue injury. Dr. Ongeri is also currently dean of the Hairston College of Health and Human Sciences and professor of physiology at North Carolina Agricultural and Technical State University (NC A&T) in Greensboro. In this interview, she shares details of her career, including a change in research focus to human physiology; her goals for the f...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - June 14, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Profiles Proteins Source Type: blogs
The global impact of tobacco control policies on smokeless tobacco use: a systematic review
Lancet Glob Health. 2023 Jun;11(6):e953-e968. doi: 10.1016/S2214-109X(23)00205-X.ABSTRACTBACKGROUND: Smokeless tobacco, used by more than 300 million people globally, results in substantial morbidity and mortality. For smokeless tobacco control, many countries have adopted policies beyond the WHO Framework Convention on Tobacco Control, which has been instrumental in reducing smoking prevalence. The impact of these policies (within and outside the Framework Convention on Tobacco Control) on smokeless tobacco use remains unclear. We aimed to systematically review policies that are relevant to smokeless tobacco and its conte...
Source: Cancer Control - May 18, 2023 Category: Cancer & Oncology Authors: Aastha Chugh Monika Arora Neha Jain Aishwarya Vidyasagaran Anne Readshaw Aziz Sheikh Jappe Eckhardt Kamran Siddiqi Mansi Chopra Masuma Pervin Mishu Mona Kanaan Muhammad Aziz Rahman Ravi Mehrotra Rumana Huque Sarah Forberger Suranji Dahanayake Zohaib Khan Source Type: research
