Filtered By:
Drug: Magnesium
Therapy: Chemotherapy

This page shows you your search results in order of date.

Order by Relevance | Date

Total 75 results found since Jan 2013.

Efficacy and safety of drug therapy for the prevention and treatment of chemotherapy-induced peripheral neuropathy: a protocol for a systematic review and network meta-analysis
This article describes a protocol for evaluating the efficacy and safety of drug therapy for the prevention and treatment of CIPN. The results of the proposed systematic review with network meta-analysis (NMA) will provide new insights into the prevention and treatment of CIPN. Methods and analysis We will conduct a literature search in MEDLINE, PubMed, Embase, Cochrane Central Register of Controlled Trials and ClinicalTrials.gov to find relevant articles published through January 2023. We will include studies that investigated the efficacy and safety of vitamin B12, goshajinkigan, non-steroidal anti-inflammatory analgesi...
Source: BMJ Open - September 12, 2023 Category: General Medicine Authors: Sato, M. T., Hasegawa, T., Noma, H., Sugita, H., Ota, E. Tags: Open access, Oncology Source Type: research

A novel chitosan-based doxepin nano-formulation for chemotherapy-induced oral mucositis: a randomized, double-blinded, placebo-controlled clinical trial
CONCLUSION: Chitosan-based doxepin nano-formulation might be a promising alternative for routine treatments of oral mucositis.PMID:37668810 | DOI:10.1007/s10787-023-01325-7
Source: Cancer Control - September 5, 2023 Category: Cancer & Oncology Authors: Nazafarin Samiraninezhad Mostafa Rezaee Ahmad Gholami Ali Amanati Maryam Mardani Source Type: research

Electrolytes Play a Role in Detecting Cisplatin-Induced Kidney Complications and May Even Prevent Them-Retrospective Analysis
Conclusions: We report that an average of 15% of patients with electrolyte abnormalities develop renal toxicity and reduced function. Moreover, electrolytes may serve as an early indicator for renal damage as part of chemotherapy complication. This indication represents 15% of renal toxicity cases. Changes in electrolyte levels have been reported with cisplatin. Specifically, it has been linked to hypomagnesemia, hypocalcemia and hypokalemia. This study will help reduce the risk of dialysis or the need for kidney transplant. It is also important to manage any underlying conditions and control patients' intake of electrolyt...
Source: Cancer Control - May 27, 2023 Category: Cancer & Oncology Authors: Bahauddeen M Alrfaei Abdulaziz O Almutairi Alaa A Aljohani Hajar Alammar Abdulaziz Asiri Yahya Bokhari Feda S Aljaser Manal Abudawood Majed Halwani Source Type: research

MgIG Attenuates Oxaliplatin-induced Hepatotoxicity through Suppression of Connexin 43 in Hepatic Stellate Cells
CONCLUSIONS: Cx43 mediated MgIG's hepatoprotective effects against oxaliplatin-induced toxicity.PMID:36969904 | PMC:PMC10037507 | DOI:10.14218/JCTH.2022.00048
Source: Clinical Colorectal Cancer - March 27, 2023 Category: Cancer & Oncology Authors: Yuzhu Cao Yawen Xia Yufei Wang Hang Shi Yuanyuan Wu Yin Lu Source Type: research

Effect of an Antacid (Aluminum Hydroxide/Magnesium Hydroxide/Simethicone) or a Proton Pump Inhibitor (Omeprazole) on the Pharmacokinetics of Tebipenem Pivoxil Hydrobromide (TBP-PI-HBr) in Healthy Adult Subjects
Antimicrob Agents Chemother. 2023 Mar 21:e0149522. doi: 10.1128/aac.01495-22. Online ahead of print.ABSTRACTTebipenem pivoxil hydrobromide (TBP-PI-HBr) is a novel oral carbapenem prodrug being developed for the treatment of serious bacterial infections. This open-label, 3-period, fixed sequence study evaluated the effect of gastric acid-reducing agents, aluminum hydroxide/magnesium hydroxide/simethicone, and omeprazole on the pharmacokinetics (PK) of tebipenem (TBP), the active moiety, following coadministration with immediate release TBP-PI-HBr during fasting. In Period 1, subjects received a single oral dose of TBP-PI-HB...
Source: Antimicrobial Agents and Chemotherapy - March 21, 2023 Category: Microbiology Authors: Gina Patel Vipul K Gupta Leanne Gasink Floni Bajraktari Yang Lei Akash Jain Praveen Srivastava Angela K Talley Source Type: research

Magnesium Supplementation May Not Be Protective against Carboplatin-Induced Nephrotoxicity But May Be Beneficial for Children Suffering Malignancies: A Randomized Clinical Trial
CONCLUSION: The current study suggests that magnesium supplementation does not prevent carboplatin-induced nephrotoxicity in children with malignancies. Anyway, we propose magnesium oxide supplementation for this group of pediatrics because magnesium is an essential element for cell and tissue growth, maintenance, and metabolism.PMID:36926429 | PMC:PMC10012022 | DOI:10.4103/abr.abr_292_21
Source: Biomed Res - March 17, 2023 Category: Research Authors: Marzie Alizadeh Hadadhania Kazem Ghaffari Abdorrahim Absalan Aygin Eghbali Roghayeh Rahimi Afzal Ali Ghasemi Aziz Eghbali Source Type: research

Wild-type IDH1 inhibition enhances chemotherapy response in melanoma
CONCLUSIONS: These results demonstrate the clinical potential of wtIDH1 inhibition as a novel and readily available combination treatment strategy for patients with advanced and refractory melanoma. Schematic shows increased wild-type IDH1 expression and activity as an adaptive response to metabolic stress induced by chemotherapy.PMID:36153582 | DOI:10.1186/s13046-022-02489-w
Source: Cell Research - September 24, 2022 Category: Cytology Authors: Mehrdad Zarei Omid Hajihassani Jonathan J Hue Hallie J Graor Alexander W Loftus Moeez Rathore Ali Vaziri-Gohar John M Asara Jordan M Winter Luke D Rothermel Source Type: research

Hypomagnesemia and Hypokalemia: Considerations for Cancer Care
This article discusses the importance of identifying and understanding the etiologies, symptoms, and treatment modalities of hypomagnesemia and hypokalemia.PMID:35604734 | DOI:10.1188/22.CJON.313-317
Source: Clinical Journal of Oncology Nursing - May 23, 2022 Category: Nursing Authors: Jismon Kuruppath Puja Patel Source Type: research