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Importance of aspartate 4 in the Mg < sup > 2+ < /sup > dependent regulation of Leishmania major PAS domain-containing phosphoglycerate kinase
Biochim Biophys Acta Proteins Proteom. 2023 Sep 17:140964. doi: 10.1016/j.bbapap.2023.140964. Online ahead of print.ABSTRACTMagnesium is an important divalent cation for the regulation of catalytic activity. Recently, we have described that the Mg2+ binding through the PAS domain inhibits the phosphoglycerate kinase (PGK) activity in PAS domain-containing PGK from Leishmania major (LmPAS-PGK) at neutral pH 7.5, but PGK activity is derepressed at acidic pH 5.5. The acidic residue within the PAS domain of LmPAS-PGK is expected to bind the cofactor Mg2+ ion at neutral pH, but which specific acidic residue(s) is/are responsibl...
Source: Biochimica et Biophysica Acta - September 19, 2023 Category: Biochemistry Authors: Gaurab Chowdhury Saroj Biswas Yuthika Dholey Puja Panja Sumit Das Subrata Adak Source Type: research

Improving the Durability of Chitosan Films through Incorporation of Magnesium, Tungsten, and Graphene Oxides for Biomedical Applications
In this study, loaded with tungsten oxide (WO3), Magnesium oxide (MgO), and graphene oxide (GO) on chitosan (CS) membrane, an inexpensive polymer casting method was successfully prepared for wound healing applications. All fabricated composites were characterized by X-ray powder diffraction (XRD), Fourier transforms infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). A scanning electron microscope (SEM) was used to study the synthesized film samples' morphology as well as their microstructure. The formed WO3/MgO@CS shows a great enhancement in the UV-Vis analysis with a highly intense peak at 401 nm and a n...
Source: Chemistry and Biodiversity - September 11, 2023 Category: Biochemistry Authors: Fatimah Alaithan Mai M Khalaf Mohamed M Gouda T A Yousef Sayed H Kenawy Mortaga M Abou-Krisha Manal F Abou Taleb Saad Shaaban Abdullah M M Alkars Hany Abd El-Lateef Source Type: research

Magnesium ions regulated ovalbumin-lysozyme heteroprotein complex: Aggregation kinetics, thermodynamics and morphologic structure
This study aims to investigate the mechanism of magnesium ions regulated ovalbumin-lysozyme (OVA-LYS) heteroprotein aggregation behavior via aggregation kinetics model, exploring the relationship between differential aggregation behavior and protein molecular structure, intermolecular interactions and thermal stability. Results showed that the aggregation rate (kapp) and maximum absorbance (Amax) of the OVA-LYS heteroprotein complex were located between OVA and LYS. Meanwhile, the thermal denaturation temperature (Td) and denaturation enthalpy (ΔH) were between the values of OVA and LYS as well. Compared with OVA, the the...
Source: International Journal of Biological Macromolecules - September 1, 2023 Category: Biochemistry Authors: Zhaohui Yan Jingbo Liu Jianqi Ren Chenman Li Zhi Wang Luyao Dai Sijia Cao Renzhao Zhang Xuanting Liu Source Type: research

Proximity ligation initiated DNAzyme-powered catalytic hairpin assembly for sensitive and accurate microRNA analysis
Anal Biochem. 2023 Aug 24:115299. doi: 10.1016/j.ab.2023.115299. Online ahead of print.ABSTRACTMicroRNAs (miRNAs) play a significant role in regulating diverse physiological processes, and are regarded as novel diagnostic biomarkers. However, the sensitive and reliable miRNA detection remains a huge challenge. Herein, we propose a proximity ligated initiated magnesium ion (Mg2+)-dependent DNAzyme-powered signal cascade for sensitive, accurate and reliable detection of miRNAs. Three signal amplification processes are involved in this approach, including the target miRNA recycle, DNAzyme powered substrate cleavage, and catal...
Source: Analytical Biochemistry - August 26, 2023 Category: Biochemistry Authors: Jiaguang Su Wenjun Zheng Yanbin Pan Source Type: research

Magnesium supplementation reduces interleukin-6 levels in metabolic syndrome
Magnes Res. 2023 Mar 1;36(1):22. doi: 10.1684/mrh.2023.0511.NO ABSTRACTPMID:37605602 | DOI:10.1684/mrh.2023.0511
Source: Magnesium Research - August 22, 2023 Category: Biochemistry Authors: Sophia Kisters Klaus Kisters Tanja Werner Timm Westhoff Hans-Georg Predel Hannes Reuter Source Type: research

Evaluation of standard versus prolonged magnesium infusion rates in hospitalized patients: a retrospective cohort study
CONCLUSION: Hospitalized general patients did not benefit from the prolonged infusion of magnesium compared to standard infusion.PMID:37605601 | DOI:10.1684/mrh.2023.0512
Source: Magnesium Research - August 22, 2023 Category: Biochemistry Authors: Halah Yaldo Renee Paxton Christopher Giuliano Source Type: research

Magnesium suppresses in vivo oxidative stress and ex vivo DNA damage induced by protracted ACTH treatment in rats
Magnes Res. 2023 Mar 1;36(1):1-13. doi: 10.1684/mrh.2023.0510.ABSTRACTOxidative stress, arising from disrupted balance between reactive oxygen/nitrogen species (ROS/RNS) and antioxidant defences, has been implicated in the pathogenesis of stress-related disorders. There is a growing body of evidence that supports the relationship between the activity of the hypothalamic-pituitary-adrenal (HPA) stress system, oxidative stress and magnesium (Mg) homeostasis. The present study aimed to explore the gap in our current understanding of antigenotoxic and protective effects of Mg supplementation against excessive ROS production in...
Source: Magnesium Research - August 22, 2023 Category: Biochemistry Authors: Vedrana Đurić Jelena Petrovi ć Du šanka Stanić Ana Ivanovi ć Jelena Kotur-Stevuljevi ć Vesna Pe šić Source Type: research

Magnesium supplementation reduces interleukin-6 levels in metabolic syndrome
Magnes Res. 2023 Mar 1;36(1):22. doi: 10.1684/mrh.2023.0511.NO ABSTRACTPMID:37605602 | DOI:10.1684/mrh.2023.0511
Source: Magnesium Research - August 22, 2023 Category: Biochemistry Authors: Sophia Kisters Klaus Kisters Tanja Werner Timm Westhoff Hans-Georg Predel Hannes Reuter Source Type: research

Evaluation of standard versus prolonged magnesium infusion rates in hospitalized patients: a retrospective cohort study
CONCLUSION: Hospitalized general patients did not benefit from the prolonged infusion of magnesium compared to standard infusion.PMID:37605601 | DOI:10.1684/mrh.2023.0512
Source: Magnesium Research - August 22, 2023 Category: Biochemistry Authors: Halah Yaldo Renee Paxton Christopher Giuliano Source Type: research

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