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Drug: Magnesium
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Total 56 results found since Jan 2013.
Magnesium-Based Compression Screws in Acute Scaphoid Fractures and Nonunions
CONCLUSIONS: Magnesium-based implants have excellent clinical outcomes when used for scaphoid fractures in eight presented cases and good to moderate clinical outcomes when used for nonunions in three of four presented cases. Additional studies are required to further analyze the differentiated applicability in scaphoid nonunion as well as overall performance when compared to non-absorbable screws in larger cohorts.PMID:36774451 | DOI:10.1007/s00268-023-06937-2
Source: Hand Surgery - February 11, 2023 Category: Surgery Authors: S ören Könneker Ulrich Sch ächinger Peter M Vogt Source Type: research
Bioactive fluorcanasite reinforced magnesium alloy-based porous bio-nanocomposite scaffolds with tunable mechanical properties
J Biomed Mater Res B Appl Biomater. 2022 Oct 8. doi: 10.1002/jbm.b.35166. Online ahead of print.ABSTRACTMagnesium (Mg) alloy-based porous bio-nanocomposite bone scaffolds were developed by powder metallurgy route. Selective alloying elements such as calcium (Ca), zinc (Zn) and strontium (Sr) were incorporated to tune the mechanical integrity while, bioactive fluorcanasite nano-particulates were introduced within the alloy system to enhance the bone tissue regeneration. Green compacts containing carbamide were fabricated and sintered using two-stage heat treatment process to achieve the targeted porosities. The microstructu...
Source: Biomed Res - October 8, 2022 Category: Research Authors: Adithya Garimella Ramya M Subrata Bandhu Ghosh Sanchita Bandyopadhyay-Ghosh Ashish Kumar Agrawal Source Type: research
Development of a multiparticulate drug delivery system for in situ amorphisation
Eur J Pharm Biopharm. 2022 Sep 30:S0939-6411(22)00216-8. doi: 10.1016/j.ejpb.2022.09.021. Online ahead of print.ABSTRACTIn the current study, the concept of multiparticulate drug delivery systems (MDDS) was applied to tablets intended for the amorphisation of supersaturated granular ASDs in situ, i.e. amorphisation by microwave irradiation within the final dosage form. The MDDS concept was hypothesised to ensure geometric and structural stability of the dosage form and to improve the in vitro disintegration and dissolution characteristics. Granules were prepared in two sizes (small and large) containing the crystalline dru...
Source: European Journal of Pharmaceutics and Biopharmaceutics - October 3, 2022 Category: Drugs & Pharmacology Authors: Tobias Palle Holm Marcel Kokott Matthias Manne Knopp Ben J Boyd Ragna Berthelsen Julian Quodbach Korbinian L öbmann Source Type: research
Mechanical and numerical investigations of biodegradable magnesium alloy screws for fracture treatment
J Biomed Mater Res B Appl Biomater. 2022 Jul 7. doi: 10.1002/jbm.b.35127. Online ahead of print.ABSTRACTSmall fracture treatment includes the use of so-called "Herbert screws". In the past years, novel resorbable materials were introduced as an alternative to the classical titanium implants. The purpose of this study was to evaluate the influence of ongoing resorption/corrosion processes on the mechanical stability screws made from the magnesium alloy MgYREZr®. Our samples consisted of two partly resorbed screws, explanted due to medical reasons after 6 and 12 weeks, respectively, and five unused reference screws. We perf...
Source: Biomed Res - July 7, 2022 Category: Research Authors: Sabrina S öntgen Ludger Keilig Koroush Kabir Anna Weber Susanne Reimann Kristian Welle Christoph Bourauel Source Type: research
Magnesium and Zinc Intake Ratio Mediates the Increase of Coronary Artery Calcification through Upregulating Interleukin 6
In conclusion, the dietary of Mg: Zn ratio, rather than individual mineral intake is associated with increased risk of CAC progression, which is mediated by pro-calcific IL-6. Therefore, the consideration of dietary intake of Zn and Mg together would play a cardio protective role among CAC patients.PMID:35289237 | DOI:10.1080/19932820.2022.2028997
Source: Atherosclerosis - March 15, 2022 Category: Cardiology Authors: Abdulhakim Al-Qaridhi Sounak Ghosh Dongling Luo Hui Huang Source Type: research
Icariin attenuates thioacetamide ‑induced bone loss via the RANKL‑p38/ERK‑NFAT signaling pathway
Mol Med Rep. 2022 Apr;25(4):126. doi: 10.3892/mmr.2022.12642. Epub 2022 Feb 16.ABSTRACTThere is an increasing incidence of destructive bone disease caused by osteoclast proliferation. This is characterized by reduced bone mass and imbalance of bone homeostasis. Icariin (ICA), a flavonoid compound isolated from Epimedium, has anti‑osteoporosis activity and inhibits the formation of osteoclasts and bone resorption. The purpose of the present study was to investigate the protective effect of ICA on osteoclastic differentiation induced by thioacetamide (TAA) and its possible mechanism in Sprague Dawley (SD) rats. In the pres...
Source: Molecular Medicine - February 16, 2022 Category: Molecular Biology Authors: Linyan Cheng Xiaoli Jin Hao Shen Xuanwei Chen Jin Chen Bin Xu Jian Xu Source Type: research
In vivo comparison of the degradation and osteointegration properties of micro-arc oxidation-coated Mg-Sr and Mg-Ca alloy scaffolds
Biomed Mater Eng. 2021 Nov 2. doi: 10.3233/BME-211300. Online ahead of print.ABSTRACTBACKGROUND: Magnesium (Mg) alloy have biodegradation and mechanical properties that are similar to those of human bone, making it a promising candidate material for inclusion in implantable medical devices.OBJECTIVE: The osteointegration effect of Mg alloy scaffolds with different corrosion rates were studied and evaluated in large bone defect models.METHOD: Mg-Sr and Mg-Ca alloy scaffolds with a 20-μm Micro-arc oxidation (MAO) coating were used to repair critical bone defects for subsequent assessment of each alloy's degradation and oste...
Source: Bio-Medical Materials and Engineering - November 8, 2021 Category: Materials Science Authors: Hongyu Sun Yuefei Wang Chu Sun Haiming Yu Zheng Xi Na Liu Nan Zhang Source Type: research
