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Drug: Lortab
Nutrition: Herbs
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Total 640 results found since Jan 2013.
Discovery of hepatoprotective activity components from Thymus quinquecostatus celak. by molecular networking, biological evaluation and molecular dynamics studies
In this study, combining molecular networking visualization and bioassay-guided fractionation strategies, a pair of novel skeleton diterpenoid enantiomers, (+)- and (-)-thymutatusone A [(+)- and (-)-1], along with one new and one known biogenetically related compounds (2-3) and 16 other known compounds (4-19), were identified from T. quinquecostatus. Their structures were exhaustively characterized by comprehensive spectroscopic data, X-ray diffraction analysis, and ECD calculations. Compounds (±)-1, (-)-1, and (+)-1, with a rare tricyclo [7.3.1.02,7] tridecane skeleton, exhibited potent hepatoprotective activity in HepG2...
Source: Bioorganic Chemistry - August 21, 2023 Category: Chemistry Authors: Xiangjian Zhong Ruolan Song Dongjie Shan Xueyang Ren Yuan Zheng Fang Lv Qingyue Deng Yingyu He Xianxian Li Ruiwen Li Li Yan Gaimei She Source Type: research
Sodium Pentaborate Prevents Acetaminophen-Induced Hepatorenal Injury by Suppressing Oxidative Stress, Lipid Peroxidation, Apoptosis, and Inflammatory Cytokines in Rats
This study showed that boron protects rats from the harmful effects of APAP by acting as an anti-inflammatory, antioxidant, and anti-apoptotic agent.PMID:37393388 | DOI:10.1007/s12011-023-03755-4
Source: Biological Trace Element Research - July 1, 2023 Category: Biology Authors: Esra Aktas Senocak Necati Utlu Seyda Kurt Sefa Kucukler Fatih Mehmet Kandemir Source Type: research
Leonurine alleviates acetaminophen-induced acute liver injury by regulating the PI3K/AKT signaling pathway in mice
In conclusion, Leo attenuated ALI, and reversed liver cell necrosis, the inflammatory response and oxidative stress-induced damage by regulating the PI3K/AKT signaling pathway.PMID:37267857 | DOI:10.1016/j.intimp.2023.110375
Source: International Immunopharmacology - June 2, 2023 Category: Allergy & Immunology Authors: Yajie Yu Shizhe Zhou Yan Wang Shuting Di Yingluo Wang Xin Huang Ying Chen Source Type: research
Pharmacokinetic and Pharmacodynamic Herb-Drug Interactions of Common Over-the-Counter Pain Medications
Biomed Chromatogr. 2023 Jan 29:e5591. doi: 10.1002/bmc.5591. Online ahead of print.ABSTRACTPain is one of the most common reasons for seeking medical intervention, and self-medication with over-the-counter medications and/or traditional herbal remedies has become increasingly popular. In this review, original articles on understanding possible herb-drug interaction between traditional herbs and four major pain medication: acetaminophen, aspirin, ibuprofen, and naproxen were compiled and analyzed. In terms of analytical methods, high-performance liquid chromatography using an isocratic eluent system coupled to biological sa...
Source: Biomedical Chromatography : BMC - January 30, 2023 Category: Biomedical Science Authors: Chung-Kai Sun Tung-Hu Tsai Source Type: research
Medication Safety in Breastfeeding
Am Fam Physician. 2022 Dec;106(6):638-644.ABSTRACTBreastfeeding is universally recognized as the preferred method of infant nutrition, but is sometimes abbreviated because of fear of harm to the infant from maternal medication. The amount of medication that enters breast milk varies based on the maternal serum concentration and the pharmacologic properties of the medication. When prescribing medications for a breastfeeding patient, those with the lowest risk to the infant should be selected, and dosing should be before the infant's longest sleep interval. Prescribers should use current, accurate resources. LactMed is a con...
Source: American Family Physician - December 15, 2022 Category: Primary Care Authors: Jeanne P Spencer Stephanie Thomas Ruth H Trondsen Pawlowski Source Type: research
Racial and ethnic differences in the pharmacologic management of osteoarthritis: rapid systematic review
CONCLUSION: This systematic review provides an overview of the current pharmacologic options for OA, with a focus on race and ethnic differences in the use of such medical therapies.PMID:35794906 | PMC:PMC9251972 | DOI:10.1177/1759720X221105011
Source: Adv Data - July 7, 2022 Category: Epidemiology Authors: Ernest R Vina Philip H Tsoukas Shahrzad Abdollahi Nidhi Mody Stephanie C Roth Albert H Redford C Kent Kwoh Source Type: research
3D scaffold fabricated with composite material for cell culture and its derived platform for safety evaluation of drugs
Toxicology. 2021 Dec 14:153066. doi: 10.1016/j.tox.2021.153066. Online ahead of print.ABSTRACTIn order to overcome the weakness of conventional approaches for cell culture, and provide cells with more in vivo-like microenvironment for studying hepatotoxicity of drugs, "multiple-in-one" strategy was adopted to fabricate a 3D scaffold of silk fibroin/hydroxyapatite/poly lacticco-glycolic acid (SF/HA/PLGA), where HepG2 cells were cultivated and the toxicity of drugs to the cells was investigated. The prepared 3D scaffold proves to bear proper porosity, excellent mechanical property, steady pH environment and good biocompatibi...
Source: Toxicology - December 17, 2021 Category: Toxicology Authors: Yanni Zhang Le Liu Na Li Yihua Wang Xuanfeng Yue Source Type: research
