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United States' regulatory approved pharmacotherapies for nuclear reactor explosions and anthrax-associated bioterrorism
Expert Opin Drug Saf. 2023 Aug 18:1-6. doi: 10.1080/14740338.2023.2245748. Online ahead of print.ABSTRACTINTRODUCTION: Nuclear reactor incidents and bioterrorism outbreaks are concerning public health disasters. Little is known about US Food and Drug Administration (FDA)-approved agents that can mitigate consequences of these events. We review FDA data supporting regulatory approvals of these agents.AREAS COVERED: We reviewed pharmaceutical products approved to treat Hematopoietic Acute Radiation Syndrome (H-ARS) and to treat or prevent pulmonary infections following Bacillus anthracis (anthrax) exposure. Four drugs were a...
Source: Expert Opinion on Drug Safety - August 18, 2023 Category: Drugs & Pharmacology Authors: Charles L Bennett Peter Georgantopoulos Robert Peter Gale Kevin Knopf William J Hrushesky Chadi Nabhan James O Armitage Source Type: research

In-Depth Study of < em > Thymus vulgaris < /em > Essential Oil: Towards Understanding the Antibacterial Target Mechanism and Toxicological and Pharmacological Aspects
Biomed Res Int. 2022 Jul 21;2022:3368883. doi: 10.1155/2022/3368883. eCollection 2022.ABSTRACTQuestions have been raised apropos the emerging problem of microbial resistance, which may pose a great hazard to the human health. Among biosafe compounds are essential oils which captured consumer draw due to their multifunctional properties compared to chemical medication drugs. Here, we examined the chemical profile and the mechanism(s) of action of the Thymus vulgaris essential oil (TVEO) against a Gram-negative bacterium Salmonella enterica Typhimurium ATTCC 10028 (S. enterica Typhimurium ATTCC 10028) and two Gram-positive b...
Source: Biomed Res - August 1, 2022 Category: Research Authors: Sarra Akermi Slim Smaoui Mariam Fourati Khaoula Elhadef Moufida Chaari Ahlem Chakchouk Mtibaa Lotfi Mellouli Source Type: research

Impact of Critical Material Attributes (CMAs)-Particle Shape on Miniature Pharmaceutical Unit Operations
This study demonstrates how needle-shaped crystals have an impact on pharmaceutical operations, even if it is on a miniature scale, and how proper shape and subsequent flow properties can be obtained by processing the particles through the MIT team-designed grinder.PMID:33709195 | DOI:10.1208/s12249-020-01915-6
Source: AAPS PharmSciTech - March 12, 2021 Category: Drugs & Pharmacology Authors: Mohammad A Azad Gerard Capellades Allison B Wang David M Klee Gregory Hammersmith Kersten Rapp David Brancazio Allan S Myerson Source Type: research

UCLA-led research reveals potential treatments for deadly tropical disease
Melioidosis is a tropical disease that claims an estimated 90,000 lives worldwide each year. There is no vaccine, and current treatments are hampered by the ability of the bacterium that causes the disease to resist even the strongest antibiotics.Hardy and lethal, that bacterium, Burkholderia pseudomallei, is classified by the Centers for Disease Control and Prevention as a potential bioweapon.UCLA-led research has identified two compounds that, based on tests on human cells and on mice, show potential for treating melioidosis. One is a widely used drug already approved by the U.S. Food and Drug Administration as an antifu...
Source: UCLA Newsroom: Health Sciences - September 11, 2019 Category: Universities & Medical Training Source Type: news

Pipe Dreams: Tapping into the Health Information in Our Sewers
The emerging field of sewage chemical-information mining is taking advantage of a readily available yet underappreciated resource: the untreated waste flowing under our feet and the biosolids remaining after treatment. It turns out that sewage and sewage sludge hold a wealth of data on chemical consumption and exposure, and potentially even the health status of whole communities.EHP Freezers at the National Sewage Sludge Repository hold hundreds of samples of raw sewage and sludge collected from more than 200 sites around the United States.© Arjunkrishna Venkatesan   Most chemicals...
Source: EHP Research - May 2, 2016 Category: Environmental Health Authors: Web Admin Tags: Featured Focus News May 2016 Source Type: research