UCLA-led research reveals potential treatments for deadly tropical disease

Melioidosis is a tropical disease that claims an estimated 90,000 lives worldwide each year. There is no vaccine, and current treatments are hampered by the ability of the bacterium that causes the disease to resist even the strongest antibiotics.Hardy and lethal, that bacterium, Burkholderia pseudomallei, is classified by the Centers for Disease Control and Prevention as a potential bioweapon.UCLA-led research has identified two compounds that, based on tests on human cells and on mice, show potential for treating melioidosis. One is a widely used drug already approved by the U.S. Food and Drug Administration as an antifungal treatment; the other is a new synthetic antibiotic. The findings, published in the Proceedings of the National Academy of Sciences, represent progress against a disease about which little is known.“Even among neglected tropical diseases, melioidosis is one of the most neglected, especially when you consider its global burden and lethality,” said senior author Jeff F. Miller, UCLA’s Fred Kavli Professor of NanoSystems Sciences, a professor of microbiology, immunology and molecular geneti cs, and director of theCalifornia NanoSystems Institute at UCLA. “It deserves more attention because of its fascinating biology as well.”Breakthrough in the Search for Biothreat Therapeutics fromThe French Lab onVimeo.Seen most often in southeast Asia and northern Australia, melioidosis can take many forms, ranging from a lethal bloodstream ...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Source: Sport Management Review - Category: Sports Medicine Source Type: research
DiscussionIntestinal TB most commonly affected region is the ileocaecal, accounts for 64% of the incidence of gastrointestinal TB. The main reasons for the predilection of ileocaecal region are due to relatively longer faecal static, the abundant of lymphoid tissue, a neutral pH environment and absorptive transport mechanisms that allow swallowed mycobacterium to be absorbed. Intestinal TB may pose similar symptoms as those found in pulmonary TB, yet patients most commonly presenting with abdominal pain. Bacteriological signs and histopathological findings are gold standard for ITB diagnosis. Therapy for ITB includes pharm...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Publication date: Available online 14 October 2019Source: Seminars in Ultrasound, CT and MRIAuthor(s): A Sureshkumar, B Hansen, D ErsahinAbstractNuclear medicine (NM) plays a unique role in the detection of infection and inflammation. This review looks at different methods that are used for detection of infections and explains how they differ from cross sectional imaging such as CT and MRI. Images are provided to aid understanding and interpretation of NM scans. There is also a brief discussion of future techniques that can alter the use of NM for infection work up.
Source: Seminars in Ultrasound, CT and MRI - Category: Radiology Source Type: research
Publication date: Available online 14 October 2019Source: NeuroImage: ClinicalAuthor(s): Robert Loughnan, Diego L. Lorca-Puls, Andrea Gajardo-Vidal, Valeria Espejo-Videla, Céline R. Gillebert, Dante Mantini, Cathy J. Price, Thomas M.H. HopeAbstractAround a third of stroke survivors suffer from acquired language disorders (aphasia), but current medicine cannot predict whether or when they might recover. Prognostic research in this area increasingly draws on datasets associating structural brain imaging data with outcome scores for ever-larger samples of stroke patients. The aim is to learn brain-behavior trends from ...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
This study aims at prospectively evaluating an adapted DWI sequence ex vivo and in vivo in oncologic patients undergoing abdominal MRI. Methods This institutional review board–approved, prospective study included phantom measurements, volunteer examinations, and oncologic patient examinations of the abdomen. Fifty-seven MRI examinations in 54 patients (mean age, 58 years; range, 21–90 years) were included into the analysis. The MRI examination were performed at a 1.5 T MRI scanner (MAGNETOM Aera; Siemens Healthcare, Erlangen, Germany) and included both a standard EPI-DWI (s-DWI; b = 50, 900 s/mm2) and an ada...
Source: Investigative Radiology - Category: Radiology Tags: Original Articles Source Type: research
Objectives The aim of this study was to compare a compressed-sensing free-breathing VIBE (fbVIBE) with a conventional breath-hold VIBE (bhVIBE) for dynamic contrast-enhanced imaging of the upper abdomen. Materials and Methods In total, 70 datasets (bhVIBE, n = 30; fbVIBE n = 40; hard-gated [hg] reconstruction, n = 30; motion-state-resolved [mr] reconstruction, n = 10) were assessed by 2 experienced readers. Both sequences were performed on 1.5-T magnetic resonance imaging scanners. The prototypical fbVIBE sequence acquired a navigation signal along with the imaging data and supported 2 different reconstructions: an hg...
Source: Investigative Radiology - Category: Radiology Tags: Original Articles Source Type: research
Publication date: Available online 15 October 2019Source: International Journal of Pediatrics and Adolescent MedicineAuthor(s): Saeed Altoom, Omar AlzomorAbstractUnreported cases of diphtheria are still present in developing countries. A 9-year-old incompletely vaccinated girl was admitted with pharyngotonsillitis caused by diphtheria. On day 9 of her illness, renal and cardiac failure occurred. Unfortunately, she died within hours of admission to intensive care with cardiogenic shock despite the vigorous supportive care delivered to her and the administration of antibiotics and diphtheria antitoxin. The suboptimal dose of...
Source: International Journal of Pediatrics and Adolescent Medicine - Category: Pediatrics Source Type: research
Publication date: Available online 14 October 2019Source: Orthopaedics &Traumatology: Surgery &ResearchAuthor(s): Charlotte Crampet, Harold Common, Emma Bajeux, Antoine Bourgoin, Hervé Thomazeau, Jean-Louis Polard, Orthopedics, Traumatology Society of Western FranceAbstractIntroductionAdvances in anesthesia and surgical practices have allowed total hip arthroplasty to be performed as an outpatient procedure. The aim of this study was to demonstrate its feasibility in a selected population compared to a group of inpatients by analyzing the cumulative length of hospital stay, complications and readmissions.Pat...
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
ConclusionsWhen applied to orthopedic stainless steel hardware in vitro, solutions of rifampin and vancomycin powder separately or in combination can completely prevent and eliminate biofilm produced by S. aureus.Level of EvidenceII;
Source: Journal of Clinical Orthopaedics and Trauma - Category: Orthopaedics Source Type: research
ConclusionPRP and vaginal laser appear to be promising alternative treatments for urinary incontinence with potential reduction in cost to both the patient and national health systems without any complications or side-effects. However, the true efficacy of these modalities need to be examined in an RCT setting.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
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