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Infectious Disease: Typhoid
Drug: Cipro
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Total 62 results found since Jan 2013.
Dynamic Incidence of Typhoid Fever over a 10-Year Period (2010-2019) in Kibera, an Urban Informal Settlement in Nairobi, Kenya
Am J Trop Med Hyg. 2023 May 30:tpmd220736. doi: 10.4269/ajtmh.22-0736. Online ahead of print.ABSTRACTTyphoid fever burden can vary over time. Long-term data can inform prevention strategies; however, such data are lacking in many African settings. We reexamined typhoid fever incidence and antimicrobial resistance (AMR) over a 10-year period in Kibera, a densely populated urban informal settlement where a high burden has been previously described. We used data from the Population Based Infectious Diseases Surveillance platform to estimate crude and adjusted incidence rates and prevalence of AMR in nearly 26,000 individuals ...
Source: Am J Trop Med Hyg - May 30, 2023 Category: Infectious Diseases Authors: Eric Ng'eno Margaret Lind Allan Audi Alice Ouma Clifford Oduor Patrick K Munywoki George O Agogo George Odongo Samuel Kiplangat Newton Wamola Mike Powel Osita Robert Mugoh Caroline Ochieng Victor Omballa Ondari D Mogeni Matthew Mikoleit Barry S Fields Joe Source Type: research
Mannosylated preactivated hyaluronic acid-based nanostructures for bacterial infection treatment
Int J Biol Macromol. 2023 May 6:124741. doi: 10.1016/j.ijbiomac.2023.124741. Online ahead of print.ABSTRACTSalmonella Typhi is an intracellular bacterium causing a variety of enteric diseases, being typhoid fever the most common. Current modalities for treating S. typhi infection are subjected to multi-drug resistance. Herein, a novel macrophage targeting approach was developed via coating bioinspired mannosylated preactivated hyaluronic acid (Man-PTHA) ligands on a self-nanoemulsifying drug delivery system (SNEDDS) loaded with the anti-bacterial drug ciprofloxacin (CIP). The shake flask method was used to determine the dr...
Source: International Journal of Biological Macromolecules - May 8, 2023 Category: Biochemistry Authors: Rabia Arshad Muhammad Salman Arshad Abdul Malik Musaed Alkholief Suhail Akhtar Tanveer A Tabish Ali Abbasi Moghadam Abbas Rahdar Ana M D íez-Pascual Source Type: research
Obstructing < em > Salmonella typhi < /em > 's virulence in eukaryotic cells through design of its SipB protein antagonists
CONCLUSION: The current findings may provide a roadmap for the discovery of more potent antibiotics against S. typhi.PMID:36852248 | PMC:PMC9957885 | DOI:10.1016/j.jtumed.2022.12.010
Source: Molecular Medicine - February 28, 2023 Category: Molecular Biology Authors: John P Ameji Adamu Uzairu Gideon A Shallangwa Sani Uba Source Type: research
Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins
CONCLUSIONS: Based on very low- to low-certainty evidence, ceftriaxone is an effective treatment for adults and children with enteric fever, with few adverse effects. Trials suggest that there may be no difference in the performance of ceftriaxone compared with azithromycin, fluoroquinolones, or chloramphenicol. Cefixime can also be used for treatment of enteric fever but may not perform as well as fluoroquinolones. We are unable to draw firm general conclusions on comparative contemporary effectiveness given that most trials were small and conducted over 20 years previously. Clinicians need to take into account current, l...
Source: Cochrane Database of Systematic Reviews - November 24, 2022 Category: General Medicine Authors: Rebecca Kuehn Nicole Stoesser David Eyre Thomas C Darton Buddha Basnyat Christopher Martin Parry Source Type: research
