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The effects of antidepressants fluoxetine, sertraline, and amitriptyline on the development of antibiotic resistance in Acinetobacter baumannii
This study investigates the effects of antidepressants fluoxetine, sertraline, and amitriptyline on the development of antibiotic resistance in clinical Acinetobacter baumannii isolates. The isolates were exposed to fluoxetine, sertraline, and amitriptyline for 30 days, respectively. The bacteria that developed resistance to gentamicin, imipenem, colistin, and ciprofloxacin were isolated and expression levels of some antibiotic-resistance genes were determined by quantitative reverse-transcriptase PCR. Before and after the exposure, minimum inhibitory concentration (MIC) values of the bacteria were determined by the microd...
Source: Archives of Microbiology - March 31, 2022 Category: Microbiology Authors: Suna Sibel Gurpinar Didem Kart Mujde Eryilmaz Source Type: research

Prevalence and associated factors of obesity in inflammatory bowel disease: A case-control study
CONCLUSION: Obese IBD patients seem to have features similar to general obese population, and there is no disease-specific factor (disease activity, extension or therapy) that may foster obesity in IBD.PMID:33384552 | PMC:PMC7754553 | DOI:10.3748/wjg.v26.i47.7528
Source: World Journal of Gastroenterology - January 1, 2021 Category: Gastroenterology Authors: Giuseppe Losurdo Rosa Federica La Fortezza Andrea Iannone Antonella Contaldo Michele Barone Enzo Ierardi Alfredo Di Leo Mariabeatrice Principi Source Type: research

Temperate Prophages Increase Bacterial Adhesin Expression and Virulence in an Experimental Model of Endocarditis Due to Staphylococcus aureus From the CC398 Lineage
Conclusion Introduction of bacteriophages from human-adapted S. aureus to a naïve animal colonizer resulted in virulent strains with altered transcription levels of important bacterial adhesins. Furthermore, the presence of bacteriophages conferred increased virulence in a model of infectious endocarditis for all lysogens tested. Author Contributions FL, A-RC, and MG performed the adhesion and internalization experiments. A-RC and NM-M performed the transduction experiments. SD performed genome assembly and comparisons. FO and JE performed endocarditis experiments. NM-M and PF designed the study. FL, NM-M, and PF...
Source: Frontiers in Microbiology - April 23, 2019 Category: Microbiology Source Type: research

Antibacterial Properties of Polyphenols: Characterization and QSAR (Quantitative Structure –Activity Relationship) Models
Conclusion Polyphenols exhibited very different antibacterial activity against the six microbial strains studied that are representative of the foodborne pathogenic and food spoilage bacteria. The same polyphenol may be effective on one type of Gram-positive (or Gram-negative) strain and ineffective on the other ones indicating strain-dependent effect. This is the case for example of 5,7-dihydroxy-4-phenylcoumarin (HUQ) which exhibited 93.5% BLD against L. monocytogenes, 89.9% BLD against S. aureus and a slight bacterial growth-promoting effect (BLD of about −26.1%) for E. coli. Moreover, the antibacterial effect ...
Source: Frontiers in Microbiology - April 17, 2019 Category: Microbiology Source Type: research

Identification of a nth-Like Gene Encoding an Endonuclease III in Campylobacter jejuni
In this study, a BER homolog encoded by cj0595c (named nth) in C. jejuni was analyzed for endonuclease III activity and for its role in maintaining genomic stability. It was found that inactivation of nth resulted in elevated frequencies of spontaneous fluoroquinolone-resistant (FQR) and oxidative stress resistant (OXR) mutants, compared with the wild-type strain in C. jejuni. Sequencing analysis of the FQR and OXR mutants revealed that the elevated mutation rates were associated with C → T or G → A transition in gyrA (FQR mutants) or perR (for OXR mutants). In an in vitro assay, a purified recombinant C. jej...
Source: Frontiers in Microbiology - April 9, 2019 Category: Microbiology Source Type: research

Celiac Disease: A Serious, Life-Changing Condition
I met Paul Graham courtesy of one of his essays.  Then, we talked by phone and I read – no devoured – his book, In Memory of Bread: A Memoir. Pardon the pun. Paul is a professor of English Department at St. Lawrence University in Canton, NY and on July 1 becomes Department Chair. He focuses on fiction and non-fiction creative writing and lives with his wife, Bec and their German shepherds. Paul, your book is the best description I’ve read about the challenges of being diagnosed with celiac. Can you summarize what happened? Given your experience, what recommendations would you have for clinicians? Should celiac be su...
Source: Disruptive Women in Health Care - June 5, 2017 Category: Consumer Health News Authors: dw at disruptivewomen.net Tags: Uncategorized Source Type: blogs