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Drug: Docetaxel
Therapy: Stem Cell Therapy
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Total 34 results found since Jan 2013.
Identification of an endoplasmic reticulum stress-related prognostic risk model with excellent prognostic and clinical value in oral squamous cell carcinoma
CONCLUSION: A prognostic model with high clinical application value was constructed. Immune cells, cellular stemness, and TMB may be involved in the progression of OSCC.PMID:37647077 | DOI:10.18632/aging.204983
Source: Aging - August 30, 2023 Category: Biomedical Science Authors: Mingyang Cheng Xin Fan Mu He Xianglin Dai Xiaoli Liu Jinming Hong Laiyu Zhang Lan Liao Source Type: research
A FOXC2 inhibitor, MC-1-F2, as a therapeutic candidate for targeting EMT in castration-resistant prostate cancer
Bioorg Med Chem Lett. 2023 Jun 6:129369. doi: 10.1016/j.bmcl.2023.129369. Online ahead of print.ABSTRACTAndrogen deprivation therapy (ADT) is the major treatment option for advanced prostate cancer. However, prostate cancer can develop into androgen-independent castration-resistant prostate cancer (CRPC) which is resistant to ADT. An alternative treatment strategy for CRPC can be targeting the epithelial-mesenchymal transition (EMT). EMT is governed by a series of transcription factors of which forkhead box protein C2 (FOXC2) is a central mediator. Our previous research into the inhibition of FOXC2 in breast cancer cells l...
Source: Bioorganic and Medicinal Chemistry Letters - June 8, 2023 Category: Chemistry Authors: Maria Castaneda Liandra Rodriguez Jihyun Oh Brittnee Cagle-White Hanna Suh May H Abdel Aziz Jiyong Lee Source Type: research
Adipocytes reprogram prostate cancer stem cell machinery
J Cell Commun Signal. 2023 Mar 20. doi: 10.1007/s12079-023-00738-x. Online ahead of print.ABSTRACTIt is now well-established that an obese condition correlates with a higher risk of prostate cancer (PCa). A crosstalk between adipose tissue and PCa has been observed but is still poorly characterized. Herein, we demonstrated that 3T3-L1 adipocyte conditioned media (CM) could endow PC3 and DU145 PCa cells with stemness properties, by stimulating their sphere formation ability and promoting CD133 and CD44 expression. Moreover, after exposure to adipocyte CM both PCa cell lines underwent partial epithelial-to-mesenchymal transi...
Source: Journal of Cell Communication and Signaling - March 20, 2023 Category: Molecular Biology Authors: Fabrizio Fontana Martina Anselmi Patrizia Limonta Source Type: research
Overcoming drug resistance with a docetaxel and disulfiram loaded pH-sensitive nanoparticle
J Control Release. 2023 Feb 23:S0168-3659(23)00134-7. doi: 10.1016/j.jconrel.2023.02.023. Online ahead of print.ABSTRACTPrevious studies have demonstrated that breast cancer cells deploy a myriad array of strategies to thwart the activity of anticancer drugs like docetaxel (DTX), including acquired drug resistance due to overexpression of drug-efflux pumps like P-glycoprotein (P-gp) and innate drug resistance by cancer stem cells (CSCs). As disulfiram (DSF) can inhibit both P-gp and CSCs, we hypothesized that co-treatment of DTX and DSF could sensitize the drug-resistant breast cancer cells. To deliver a fixed dose ratio o...
Source: Cancer Control - February 25, 2023 Category: Cancer & Oncology Authors: K Laxmi Swetha Milan Paul Kavya Sree Maravajjala Soniya Kumbham Swati Biswas Aniruddha Roy Source Type: research
Pharmacological ascorbate potentiates combination nanomedicines and reduces cancer cell stemness to prevent post-surgery recurrence and systemic metastasis
Biomaterials. 2023 Feb 8;295:122037. doi: 10.1016/j.biomaterials.2023.122037. Online ahead of print.ABSTRACTConventional chemotherapy targets proliferative cancer cells to halt tumor progression or regress tumors. However, the plasticity of tumor cells enables their phenotypical changes to acquire chemo-resistance, leading to treatment failure or tumor recurrence after a successful treatment course. Here, we report the use of high-dose pharmacologic ascorbate to potentiate treatment efficacy of nanoscale coordination polymers (NCPs) delivering two clinical combinations of chemotherapeutics, carboplatin/docetaxel and oxalip...
Source: Biomaterials - February 11, 2023 Category: Materials Science Authors: Xiaomin Jiang Jianqiao Liu Jianming Mao Wenbo Han Yingjie Fan Taokun Luo Junjie Xia Morten J Lee Wenbin Lin Source Type: research
Therapeutic Implications for Intrinsic Phenotype Classification of Metastatic Castration Resistant Prostate Cancer
CONCLUSIONS: Subtyping of mCRPC based on cell differentiation states has potential clinical utility for identifying patients with divergent expression of treatment targets and responses to systemic therapy.PMID:35552660 | DOI:10.1158/1078-0432.CCR-21-4289
Source: Clinical Cancer Research - May 13, 2022 Category: Cancer & Oncology Authors: Ilsa M Coleman Navonil DeSarkar Colm Morrissey Li Xin Martine P Roudier Erolcan Sayar Dapei Li Eva Corey Michael C Haffner Peter S Nelson Source Type: research
