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Specialty: Molecular Biology
Drug: Taxotere
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Total 97 results found since Jan 2013.
A novel self-assembled nanoplatform based on retrofitting poloxamer 188 for triple-negative breast cancer targeting treatment
In this study, a novel self-assembled nanoplatform was developed for active targeting of folate receptor-overexpressing triple-negative breast cancer. This platform, FPP NPs, was prepared by the retrofitted poloxamer 188 derivatives, resulting in nanoparticles with an appropriate size (<100 nm), good stability, and satisfactory biocompatibility. Cellular uptake and in vivo distribution studies showed that the FPP NPs had strong tumor cell uptake and active targeting capabilities. Furthermore, docetaxel (DTX) was loaded into FPP NPs in this research. The resulting DTX/FPP NPs exhibited high drug encapsulation efficiency ...
Source: Chemico-Biological Interactions - September 16, 2023 Category: Molecular Biology Authors: Xueyan Hou Yalin Guan Sisi He Zeqing Wu Jintao Bai Jingjing Xu Jingwen Wang Suyue Xu Huiqing Zhu Yanyan Yin Xue Yang Yongli Shi Source Type: research
Corrigendum Crocetin induces apoptosis of BGC ‑823 human gastric cancer cells
Mol Med Rep. 2023 Aug;28(2):151. doi: 10.3892/mmr.2023.13038. Epub 2023 Jun 23.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that Fig. 2 (showing morphological characteristics of cultured BGC‑823 cells as visualized by microscopic analysis) and Fig. 3 (showing crocetin‑induced apoptosis of the BGC‑823 cells) on p. 523 appeared to feature panels containing overlapping data. The authors re‑examined their original data, and realized that inadvertent errors were made during the compilation of these figures; specifically, the data shown in Fig. 2C (for the th...
Source: Molecular Medicine - June 23, 2023 Category: Molecular Biology Authors: Ke He Picheng Si Hanning Wang Usman Tahir Kaiyun Chen Jinfeng Xiao Xiaopeng Duan Rui Huang Guoan Xiang Source Type: research
Adipocytes reprogram prostate cancer stem cell machinery
J Cell Commun Signal. 2023 Mar 20. doi: 10.1007/s12079-023-00738-x. Online ahead of print.ABSTRACTIt is now well-established that an obese condition correlates with a higher risk of prostate cancer (PCa). A crosstalk between adipose tissue and PCa has been observed but is still poorly characterized. Herein, we demonstrated that 3T3-L1 adipocyte conditioned media (CM) could endow PC3 and DU145 PCa cells with stemness properties, by stimulating their sphere formation ability and promoting CD133 and CD44 expression. Moreover, after exposure to adipocyte CM both PCa cell lines underwent partial epithelial-to-mesenchymal transi...
Source: Journal of Cell Communication and Signaling - March 20, 2023 Category: Molecular Biology Authors: Fabrizio Fontana Martina Anselmi Patrizia Limonta Source Type: research
< sup > 225 < /sup > Ac-PSMA-617 radioligand therapy of de novo metastatic hormone-sensitive prostate carcinoma (mHSPC): preliminary clinical findings
CONCLUSIONS: Given these favorable results, randomized prospective multicenter trials assessing the clinical value of 225Ac-PSMA-617 as a therapeutic agent for mHSPC administered either as monotherapy or administered concomitant with ADT are of interest.PMID:36864360 | DOI:10.1007/s00259-023-06165-9
Source: Molecular Medicine - March 2, 2023 Category: Molecular Biology Authors: Mike Sathekge Frank Bruchertseifer Mariza Vorster Ismaheel O Lawal Kgomotso Mokoala Janet Reed Letjie Maseremule Honest Ndlovu Khanyi Hlongwa Alex Maes Alfred Morgenstern Christophe Van de Wiele Source Type: research
Identification of a novel eighteen-gene signature of recurrent metastasis neuroblastoma
In conclusion, our study offers a novel metastasis biomarker and helps understand the mechanisms of tumor recurrent metastasis. KEY MESSAGES: We identified a novel eighteen-gene signature of recurrent metastasis neuroblastoma and build risk and classification models. We dissected the regulatory role of NCAPG in signatures. We found immune exhaustion and immunosuppression in recurrent metastasis neuroblastoma. Vinorelbine and docetaxel were predicted to have high sensitivity against recurrent metastatic neuroblastoma.PMID:36856811 | DOI:10.1007/s00109-023-02299-3
Source: Molecular Medicine - March 1, 2023 Category: Molecular Biology Authors: Shufan Zhang Rong Jiang Manqiu Yang Tao Wang Hui Chen Yifan Shi Wei Liu Moli Huang Source Type: research
STAT3 inhibitor Stattic and its analogues inhibit STAT3 phosphorylation and modulate cytokine secretion in senescent tumour cells
Mol Med Rep. 2023 Apr;27(4):81. doi: 10.3892/mmr.2023.12968. Epub 2023 Feb 24.ABSTRACTSignal transducer and activator of transcription 3 (STAT3) signalling serves an important role in carcinogenesis and cellular senescence, and its inhibition in tumour cells represents an attractive therapeutic target. Premature cellular senescence, a process of permanent proliferative arrest of cells in response to various inducers, such as cytostatic drugs or ionizing radiation, is accompanied by morphological and secretory changes, and by altered susceptibility to chemotherapeutic agents, which can thereby complicate their eradication b...
Source: Molecular Medicine - February 24, 2023 Category: Molecular Biology Authors: Romana Mikyskova Olena Sapeg Miroslav Psotka Ondrej Novotny Zden ěk Hodny Sona Balintova David Malinak Jana Svobodova Rudolf Andrys David Rysanek Kamil Musilek Milan Reinis Source Type: research
The prognostic gene CRABP2 affects drug sensitivity by regulating docetaxel-induced apoptosis in breast invasive carcinoma: A pan-cancer analysis
Chem Biol Interact. 2023 Jan 31:110372. doi: 10.1016/j.cbi.2023.110372. Online ahead of print.ABSTRACTCellular retinoic acid-binding protein 2 (CRABP2), a specific transporter of retinoic acid, has been shown to have an important biological role in human cancers. However, due to the substantial variability among different tumors, the role of CRABP2 remains uncertain and has not yet been subjected to systematic analysis. Utilizing The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), Clinical Proteomic Tumor Analysis Consortium (CPTAC), Human Protein Atlas (HPA), Gene Expression Profiling Interactive Analysis 2...
Source: Chemico-Biological Interactions - February 3, 2023 Category: Molecular Biology Authors: Shuangshuang Zeng Zhijie Xu Qiuju Liang Abhimanyu Thakur Yuanhong Liu Shangjun Zhou Yuanliang Yan Source Type: research
Acquired drug resistance interferes with the susceptibility of prostate cancer cells to metabolic stress
CONCLUSIONS: Collectively, our data identify the mechanisms that underlie the limited potential of metformin for the chemotherapy of drug-resistant tumors. Metformin can enhance the sensitivity of cancer cells to chemotherapy by inducing their metabolic decoupling/imbalance. However, the acquired chemoresistance of cancer cells impairs this effect, facilitates cellular adaptation to metabolic stress, and prompts the invasive front formation.PMID:36401206 | PMC:PMC9673456 | DOI:10.1186/s11658-022-00400-1
Source: Mol Biol Cell - November 19, 2022 Category: Molecular Biology Authors: Jessica Catapano Marcin Luty Tomasz Wr óbel Maciej Pude łek Katarzyna Piwowarczyk Sylwia K ędracka-Krok Maciej Siedlar Zbigniew Madeja Jaros ław Czyż Source Type: research
Alpha-tubulin relocalization is involved in calcium oxalate-induced tight junction disruption in renal epithelial cells
This study thus addressed the involvement of a major MT protein, α-tubulin, in COM-induced TJ disruption. Protein-protein interactions analysis demonstrated that α-tubulin directly interacted with a TJ protein, zonula occludens-1 (ZO-1). MDCK renal cells were polarized and incubated with COM crystals for 48 h. Western blotting showed that COM reduced ZO-1, but not α-tubulin, level. Immunofluorescence staining revealed COM-induced relocalization of α-tubulin from apical membranes to cytoplasm and ZO-1 disruption at cell borders. COM also mediated progressive fall of epithelial barrier function, represented by transepith...
Source: Chemico-Biological Interactions - November 9, 2022 Category: Molecular Biology Authors: Sudarat Hadpech Paleerath Peerapen Visith Thongboonkerd Source Type: research
Reduced Expression of the Tissue-Specific Oct-IL Isoform Exerts an Antitumor Effect on Namalwa Burkitt's Lymphoma Cells
We report here that targeted suppression of the tissue-specific Oct-1L isoform expression reduces the proliferation rate of Namalwa B-lymphoblastic Burkitt's lymphoma cells, significantly increases cell death rate under hypoxic conditions, and makes cells more sensitive to chemotherapeutic agents such as docetaxel and doxorubicin. These results indicate that targeted therapy aimed at the suppression of the Oct-1 isoforms with increased expression levels in tumor cells rather than the total Oct-1, thus avoiding the traumatic effects of total Oct-1 knockdown, may be promising. Selective suppression of Oct-1 isoforms is a pro...
Source: Molekuliarnaia Biologiia - August 14, 2022 Category: Molecular Biology Authors: T N Portseva A P Kotnova E V Bulavkina A A Makarova S G Georgieva A G Stepchenko E V Pankratova Source Type: research
