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Overexpression of ASPM, CDC20, and TTK Confer a Poorer Prognosis in Breast Cancer Identified by Gene Co-expression Network Analysis
In conclusion, our WGCNA analysis identified candidate prognostic biomarkers for further basic and clinical researches. Introduction Breast cancer is a frequently diagnosed malignancy and the leading cause of cancer death among females around the world, accounting for 24% of cancer diagnoses and 15% of cancer deaths in females. According to Global Cancer Statistics 2018, there will be nearly 2.1 million new cases diagnosed globally, with ~62 thousand deaths. The incident rates of breast cancer increased in most developing countries during last decades, resulting from a combination of social and economic facto...
Source: Frontiers in Oncology - April 23, 2019 Category: Cancer & Oncology Source Type: research

Identification of a Novel Bcl-2 Inhibitor by Ligand-Based Screening and Investigation of Its Anti-cancer Effect on Human Breast Cancer Cells
Conclusions In this study, a virtual screening process including RF classification and regression models was applied to identify the novel Bcl-2 inhibitors. We finally screened out the compound M1 as a novel Bcl-2 small molecule inhibitor, which binds to and down-regulates Bcl-2, has significant cytotoxic effect by inducing mitochondria-mediated apoptosis. Compound M1 could be a novel and promising hit or lead compound for further structural optimization in drug discovery. Ethics Statement We have explored the anti-tumor effect of Compound M1 in vitro. The human breast cancer cell lines MDA-MB-231, T47D, and BT549, were...
Source: Frontiers in Pharmacology - April 16, 2019 Category: Drugs & Pharmacology Source Type: research