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Drug: Tamoxifen
Therapy: Endocrine Therapy
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Total 334 results found since Jan 2013.
Oestrogen receptor-independent actions of oestrogen in cancer
Mol Biol Rep. 2023 Sep 20. doi: 10.1007/s11033-023-08793-8. Online ahead of print.ABSTRACTOestrogen, the primary female sex hormone, plays a significant role in tumourigenesis. The major pathway for oestrogen is via binding to its receptor [oestrogen receptor (ERα or β)], followed by nuclear translocation and transcriptional regulation of target genes. Almost 70% of breast tumours are ER + , and endocrine therapies with selective ER modulators (tamoxifen) have been successfully applied. As many as 25% of tamoxifen-treated patients experience disease relapse within 5 years upon completion of chemotherapy. In such cases, t...
Source: Molecular Biology Reports - September 21, 2023 Category: Molecular Biology Authors: Prarthana Gopinath Revathi Paramasivam Oviya Gopal Gopisetty Source Type: research
Thyroid hormone enhances estrogen-mediated proliferation and cell cycle regulatory pathways in steroid receptor-positive breast Cancer
In this report, we show TH ± E2 ± tamoxifen inhibits cell cycle control signaling, reduces apoptosis, and enhances cell proliferation, tumor growth, tamoxifen resistance, and clonal expansion. Mechanistically these changes involve numerous genes and pathways, including critical cell cycle regulatory proteins and genes identified using various molecular methods. These studies facilitate a greater mechanistic understanding of the biological and molecular impact of TH on SR+ BC.PMID:37723865 | DOI:10.1080/15384101.2023.2249702
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Reema S Wahdan-Alaswad Susan M Edgerton Hyun Min Kim Aik Choon Tan Bryan R Haugen Bolin Liu Ann D Thor Source Type: research
< em > CYP2C19*17 < /em > association with higher plasma 4-hydroxy tamoxifen in Pakistani (estrogen-positive) breast cancer patients
This study was conducted to explore the influence of genetic polymorphisms in CYP2C19 gene on Tam's pharmacogenetics and pharmacokinetics in estrogen-positive BC patients. Data from healthy, unrelated individuals (n = 410; control group) and ER-positive BC patients (n = 430) receiving 20 mg of Tam per day were recruited. Steady-state plasma concentrations of Tam and its three metabolites were quantified using the high-performance liquid chromatography in the patients. The CYP2C19 polymorphisms were genotyped using an Amplification Refractory Mutation System-Polymerase Chain Reaction (ARMS-PCR) approach. More than 65% of he...
Source: Cancer Control - September 9, 2023 Category: Cancer & Oncology Authors: Muhammad Usman Tareen Sana Riaz Saima Shakil Malik Sana Zahid Anum Khursheed Fizza Tariq Faiza Abbas Muhammad Nouman Malik Riffat Aysha Anis Mariam Anees Iram Murtaza Aneesa Sultan Source Type: research
Oral Health Concerns of Female Breast Cancer Survivors on Adjuvant Endocrine Therapy
CONCLUSIONS: Data analysis showed that female breast cancer survivors taking adjuvant endocrine therapy appear more likely to have oral health issues than those not taking such therapy. Improved awareness of these issues is critical. Assessment and management guidelines to address these oral health issues are needed by health care providers.PMID:37678330 | DOI:10.1097/01.NAJ.0000978924.32557.53
Source: The American Journal of Nursing - September 7, 2023 Category: Nursing Authors: So-Hyun Park Shiela M Strauss Source Type: research
Breast cancer and incidence of type 2 diabetes mellitus: a systematic review and meta-analysis
CONCLUSION: Our findings suggest an elevated risk of T2D in breast cancer survivors, particularly after tamoxifen therapy. Further research is needed to determine the impact of aromatase inhibitors, and chemotherapy on the incidence of T2D after breast cancer.PMID:37656235 | DOI:10.1007/s10549-023-07043-6
Source: Clinical Genitourinary Cancer - September 1, 2023 Category: Cancer & Oncology Authors: Nanna Jordt Kasper Aalb æk Kjærgaard Reimar W Thomsen Signe Borgquist Deirdre Cronin-Fenton Source Type: research
