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Specialty: Endocrinology
Drug: Dexamethasone

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Total 303 results found since Jan 2013.

Second-line tests in the differential diagnosis of neoplastic and non-neoplastic hypercortisolism: a systematic review and meta-analysis
DiscussionBoth Dex-CRH and Desmopressin tests can be valid tools in helping discrimination between NNH/pCS and CS. Further studies are needed on this topic, possibly focusing on mild Cushing ’s Disease and well-characterized NNH/pCS patients.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022359774, identifier CRD42022359774.
Source: Journal of Endocrinological Investigation - September 22, 2023 Category: Endocrinology Source Type: research

Safety of antenatal predniso(lo)ne and dexamethasone on fetal, neonatal and childhood outcomes: a systematic review
CONCLUSIONS: Based on the limited evidence found in this systematic review, predniso(lo)ne may have less side-effects compared to dexamethasone in short- and long-term outcomes. Current literature shows minimal risk of side-effects in the newborn by administration of a prenatal predniso(lo)ne dose of up to 10 mg per day.PMID:37715964 | DOI:10.1210/clinem/dgad547
Source: The Journal of Clinical Endocrinology and Metabolism - September 16, 2023 Category: Endocrinology Authors: Elise M A Slob Jacqueline U M Termote Janna W Nijkamp Hetty J Van der Kamp Erica L T van den Akker Source Type: research

Anorexia Nervosa and Adrenal Hormones: A Systematic Review and Meta-analysis
CONCLUSIONS: Women with anorexia nervosa have higher cortisol levels and lower DHEA-S and testosterone levels compared to women without anorexia nervosa. This finding is important to consider when evaluating low-weight women for disorders involving the adrenal axis, especially Cushing's syndrome.PMID:37669399 | DOI:10.1093/ejendo/lvad123
Source: European Journal of Endocrinology - September 5, 2023 Category: Endocrinology Authors: Subhanudh Thavaraputta Patompong Ungprasert Selma F Witchel Pouneh K Fazeli Source Type: research

Oral cortisol and dexamethasone intake: differential physiology and transcriptional responses in the marine juvenile Sparus aurata
This study approached the long-term oral administration of cortisol (F) and dexamethasone (DEX), two synthetic glucocorticoids, compared to a control group (CT) in the juveniles of a marine teleost, the gilthead seabream (Sparus aurata). Physiologically, DEX treatment impaired growth, which appears to be linked to carbohydrate allocation in muscle and liver, hepatic triglycerides depletion, and reduced hematocrit. Hypophyseal gh mRNA expression was 2-fold higher in DEX than in CT or F groups. Similarly, hypothalamic trh and hypophyseal pomcb followed this pattern. Plasma cortisol levels were significantly lower in DEX than...
Source: General and Comparative Endocrinology - August 28, 2023 Category: Endocrinology Authors: A Barany J Fuentes V Valderrama A Broz-Ruiz G Mart ínez-Rodríguez J M Mancera Source Type: research

Prevalence and clinical features of armadillo repeat-containing 5 mutations carriers in a single center cohort of patients with bilateral adrenal incidentalomas
CONCLUSIONS: In MACS+ BAI patients, germline ARMC5 gene pathogenic variants are frequent. Further studies are needed to elucidate the pathophysiological role of somatic ARMC5 pathogenic variants on adrenal tumor development in otherwise wild-type (WT) patients.PMID:37625448 | DOI:10.1093/ejendo/lvad088
Source: European Journal of Endocrinology - August 25, 2023 Category: Endocrinology Authors: Morelli Valentina Elli Francesca Marta Frigerio Sofia Vena Walter Palmieri Serena Lucca Camilla Maffini Maria Antonia Contarino Andrea Bagnaresi Francesca Mantovani Giovanna Arosio Maura Source Type: research

High Prevalence of Frailty in Patients with Adrenal Adenomas and Adrenocortical Hormone Excess - a cross-sectional multi-centre study with prospective enrolment
CONCLUSION: While frailty prevalence was highest in patients with adrenocortical hormone excess, even patients with NFA demonstrated an increased prevalence compared to the referent population. Future longitudinal studies are needed to evaluate the impact of various management strategies on frailty.PMID:37590964 | DOI:10.1093/ejendo/lvad113
Source: European Journal of Endocrinology - August 17, 2023 Category: Endocrinology Authors: Prerna Dogra Lana Šambula Jasmine Saini Karthik Thangamuthu Shobana Athimulam Danae A Delivanis Dimitra A Baikousi Rohit Nathani Catherine D Zhang Natalia Genere Zara Salman Adina F Turcu Urszula Ambroziak Raul Gregg Garcia Sara J Achenbach Elizabeth J A Source Type: research

Ovine CRH stimulation and 8 mg dexamethasone suppression tests in 323 patients with ACTH-dependent Cushing's syndrome
CONCLUSIONS: CRH is a valuable tool to correctly diagnose the etiology of ACTH-dependent CS. Its current world-wide unavailability impedes optimal management of these patients.PMID:37531629 | DOI:10.1210/clinem/dgad454
Source: The Journal of Clinical Endocrinology and Metabolism - August 2, 2023 Category: Endocrinology Authors: Henrik Elenius Raven McGlotten Lynnette K Nieman Source Type: research