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Total 26 results found since Jan 2013.
Recommendations for the management of COVID-19 in patients with haematological malignancies or haematopoietic cell transplantation, from the 2021 European Conference on Infections in Leukaemia (ECIL 9)
Leukemia. 2022 Apr 29. doi: 10.1038/s41375-022-01578-1. Online ahead of print.ABSTRACTSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel virus that spread worldwide from 2019 causing the Coronavirus disease 19 (COVID-19) pandemic. SARS-CoV-2 infection is characterised by an initial viral phase followed in some patients by a severe inflammatory phase. Importantly, immunocompromised patients may have a prolonged viral phase, shedding infectious viral particles for months, and absent or dysfunctional inflammatory phase. Among haematological patients, COVID-19 has been associated with high mortality rate i...
Source: Cancer Control - April 29, 2022 Category: Cancer & Oncology Authors: Simone Cesaro Per Ljungman Malgorzata Mikulska Hans H Hirsch Marie von Lilienfeld-Toal Catherine Cordonnier Sylvain Meylan Varun Mehra Jan Styczynski Francesco Marchesi Caroline Besson Fausto Baldanti Raul Cordoba Masculano Gernot Beutel Herman Einsele El Source Type: research
Interventions for focal segmental glomerulosclerosis in adults
CONCLUSIONS: No RCTs, which evaluated corticosteroids, were identified although the KDIGO guidelines recommend corticosteroids as the first treatment for adults with FSGS. The studies identified included participants with steroid-resistant FSGS. Treatment with cyclosporin for at least six months was more likely to achieve complete remission of proteinuria compared with other treatments but there was considerable imprecision due to few studies and small participant numbers. In future studies of existing or new interventions, the investigators must clearly define the populations included in the study to provide appropriate r...
Source: Cochrane Database of Systematic Reviews - February 28, 2022 Category: General Medicine Authors: Elisabeth M Hodson Aditi Sinha Tess E Cooper Source Type: research
The effect of intervention versus watchful waiting on disease progression and overall survival in smoldering multiple myeloma: a systematic review of randomized controlled trials
ConclusionTrials of lenalidomide in a less intensive approach has shown promise in delaying disease progression and should be investigated further in clinical trials.
Source: Journal of Cancer Research and Clinical Oncology - January 20, 2022 Category: Cancer & Oncology Source Type: research
President Trump received dexamethasone and had 2 episodes of low oxygen saturation levels
President Trump was administered dexamethasone therapy for COVID-19 treatment, and had two episodes of low oxygen saturation levels that required supplemental oxygen, said doctors at Walter Reed Medical Center at a press conference on Sunday.“In response to transient low oxygen levels, we did initiate dexamethasone therapy [and] our plan is to continue that for […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more.
Source: Kevin, M.D. - Medical Weblog - October 4, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/molly-walker" rel="tag" > Molly Walker < /a > < /span > Tags: Conditions COVID-19 coronavirus Infectious Disease Source Type: blogs
Glucocorticoid replacement regimens for treating congenital adrenal hyperplasia.
CONCLUSIONS: There are currently limited trials comparing the efficacy and safety of different glucocorticoid replacement regimens for treating 21-hydroxylase deficiency CAH in children and adults and we were unable to draw any firm conclusions based on the evidence that was presented in the included trials. No trials included long-term outcomes such as quality of life, prevention of adrenal crisis, presence of osteopenia, presence of testicular or ovarian adrenal rest tumours, subfertility and final adult height. There were no trials examining a modified-release formulation of HC or use of 24-hour circadian continuous sub...
Source: Cochrane Database of Systematic Reviews - March 18, 2020 Category: General Medicine Authors: Ng SM, Stepien KM, Krishan A Tags: Cochrane Database Syst Rev Source Type: research
Multiple drug combinations of bortezomib, lenalidomide, and thalidomide for first-line treatment in adults with transplant-ineligible multiple myeloma: a network meta-analysis.
CONCLUSIONS: Based on our four pre-selected comparisons of interest, continuous treatment with VRD had the largest survival benefit compared with MP, while RD and TMP also probably considerably increase survival. However, treatment combinations of V, R, and T also substantially increase the incidence of AEs, and lead to a higher risk of treatment discontinuation. Their effectiveness and safety profiles may best be analysed in further randomised head-to-head trials. Further trials should focus on consistent reporting of safety outcomes and should use a standardised instrument to evaluate QoL to ensure comparability of treat...
Source: Cochrane Database of Systematic Reviews - November 24, 2019 Category: General Medicine Authors: Piechotta V, Jakob T, Langer P, Monsef I, Scheid C, Estcourt LJ, Ocheni S, Theurich S, Kuhr K, Scheckel B, Adams A, Skoetz N Tags: Cochrane Database Syst Rev Source Type: research
Interventions for idiopathic steroid-resistant nephrotic syndrome in children.
CONCLUSIONS: To date RCTs have demonstrated that CNIs may increase the likelihood of complete or partial remission compared with placebo/no treatment or CPA. For other regimens assessed, it remains uncertain whether the interventions alter outcomes because the certainty of the evidence is low. Further adequately powered, well designed RCTs are needed to evaluate other regimens for children with idiopathic SRNS. Since SRNS represents a spectrum of diseases, future studies should enrol children from better defined groups of patients with SRNS.
PMID: 31749142 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - November 20, 2019 Category: General Medicine Authors: Liu ID, Willis NS, Craig JC, Hodson EM Tags: Cochrane Database Syst Rev Source Type: research
Fetal-Neonatal Alloimmune Thrombocytopenia (FNAIT): Guidance to Reduce the Risk of Intracranial Bleeding
ConclusionsThe intent of this guidance document developed from systematic reviews is to promote best practices in the management of FNAIT. The guideline development group developed algorithms for treatment, podcasts for physicians and patients, pamphlets for patients and a slide set to assist with the implementation of recommendations into practice. This expert panel identified key areas for future research. One is the optimal approach to antenatal management of the next affected pregnancy. Developing biomarkers of fetal severity would be critical to this endeavor. In addition, creating comprehensive screening to identify ...
Source: Blood - November 21, 2018 Category: Hematology Authors: Lieberman, L., Greinacher, A., Murphy, M. F., Bakchoul, T., Corke, S., Tanael, S., Kjaer, M., Kjeldsen-Kragh, J., Bertrand, G., Oepkes, D., Baker, J. M., Hume, H., Massey, E., Bussel, J. B., Kaplan, C., Arnold, D. M., Baidya, S., Ryan, G., Savoia, H., Lan Tags: 901. Health Services Research-Non-Malignant Conditions: Poster III Source Type: research
Relative Efficacy of Treatment Options in Newly Diagnosed Multiple Myeloma: Results from a Systematic Literature Review and Network Meta-Analysis
Conclusions: This analysis confirms Rd to be superior to other licensed treatments currently available, in terms of both PFS and OS. Of emerging treatment options, based on current published evidence, only RVd significantly extends PFS and OS.DisclosuresRamasamy: Celgene Corp.: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Takeda: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Janssen: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; AMgen: Honoraria, Membership on an entit...
Source: Blood - November 21, 2018 Category: Hematology Authors: Ramasamy, K., Thom, H., D'Souza, V. K., Buchanan, V., Dhanasiri, S. Tags: 902. Health Services Research-Malignant Diseases: Poster III Source Type: research
Evaluating the effectiveness of systemic corticosteroids to mitigate relapse in children assessed and treated for acute asthma: A network meta-analysis.
CONCLUSION: This review found evidence that SCS corticosteroids reduce relapse in children following treatment for acute asthma, albeit based on a limited number of studies. Additional studies are required to assess the differential effect of SCS doses and treatment duration to prevent relapse in children following discharge for acute asthma.
PMID: 29693459 [PubMed - as supplied by publisher]
Source: Journal of Asthma - April 26, 2018 Category: Respiratory Medicine Tags: J Asthma Source Type: research
Osmotic therapies added to antibiotics for acute bacterial meningitis.
CONCLUSIONS: Glycerol was the only osmotic therapy evaluated, and data from trials to date have not demonstrated an effect on death. Glycerol may reduce neurological deficiency and deafness.
PMID: 29405037 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - February 6, 2018 Category: General Medicine Authors: Wall EC, Ajdukiewicz KM, Bergman H, Heyderman RS, Garner P Tags: Cochrane Database Syst Rev Source Type: research
Hypothalamic-pituitary-adrenal (HPA) axis suppression after treatment with glucocorticoid therapy for childhood acute lymphoblastic leukaemia.
CONCLUSIONS: We concluded that adrenal insufficiency commonly occurs in the first days after cessation of glucocorticoid therapy for childhood ALL, but the exact duration is unclear. No data were available on the levels of the hypothalamus and the pituitary; therefore, we could draw no conclusions regarding these outcomes. Clinicians may consider prescribing glucocorticoid replacement therapy during periods of serious stress in the first weeks after cessation of glucocorticoid therapy for childhood ALL to reduce the risk of life-threatening complications. However, additional high-quality research is needed to inform eviden...
Source: Cochrane Database of Systematic Reviews - November 6, 2017 Category: General Medicine Authors: Rensen N, Gemke RJ, van Dalen EC, Rotteveel J, Kaspers GJ Tags: Cochrane Database Syst Rev Source Type: research
Late ( > 7 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants.
CONCLUSIONS: Benefits of late corticosteroid therapy may not outweigh actual or potential adverse effects. This review of postnatal systemic corticosteroid treatment for bronchopulmonary dysplasia initiated after seven days of age suggests that late therapy may reduce neonatal mortality without significantly increasing the risk of adverse long-term neurodevelopmental outcomes. However, the methodological quality of studies determining long-term outcomes is limited in some cases (some studies assessed surviving children only before school age, when some important neurological outcomes cannot be determined with certainty), a...
Source: Cochrane Database of Systematic Reviews - October 24, 2017 Category: General Medicine Authors: Doyle LW, Cheong JL, Ehrenkranz RA, Halliday HL Tags: Cochrane Database Syst Rev Source Type: research
Early ( < 8 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants.
CONCLUSIONS: Benefits of early postnatal corticosteroid treatment (≤ 7 days), particularly dexamethasone, may not outweigh adverse effects associated with this treatment. Although early corticosteroid treatment facilitates extubation and reduces risk of bronchopulmonary dysplasia and patent ductus arteriosus, it causes short-term adverse effects including gastrointestinal bleeding, intestinal perforation, hyperglycaemia, hypertension, hypertrophic cardiomyopathy, and growth failure. Long-term follow-up studies report increased risk of abnormal findings on neurological examination and increased risk of cerebral palsy. How...
Source: Cochrane Database of Systematic Reviews - October 24, 2017 Category: General Medicine Authors: Doyle LW, Cheong JL, Ehrenkranz RA, Halliday HL Tags: Cochrane Database Syst Rev Source Type: research
