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Increased risk of stroke and myocardial infarction in patients with epilepsy: A systematic review of population-based cohort studies.
CONCLUSIONS: Patients with epilepsy are at higher risk of subsequent stroke and MI in comparison with subjects without epilepsy. Although individual AEDs may carry different risks of cardio- and cerebrovascular disease, the clinical relevance of the metabolic effects of the enzyme-inducing AEDs is still uncertain. This article is part of the Special Issue "Seizures & Stroke. PMID: 31182394 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - June 6, 2019 Category: Neurology Authors: Brigo F, Lochner P, Nardone R, Manganotti P, Lattanzi S Tags: Epilepsy Behav Source Type: research

A Study of Convulsive Status Epilepticus Cases in Indonesia
Publication date: Available online 14 March 2019Source: Epilepsy & Behavior Case ReportsAuthor(s): Machlusil Husna, K. Shahdevi Nandar, Risma Karlina Prabawati, Siti NurlaelaAbstractStatus epilepticus (SE) is a serious health issue in developing countries, with high morbidity and mortality rates of 3%–46%. There are two types of SE, convulsive status epilepticus (CSE) and non-convulsive status epilepticus. The most common type, CSE, is easy to detect but, in several cases, the patients are diagnosed too late to be properly treated and hospitalized. The present study therefore investigated the clinical manifestations of C...
Source: Epilepsy and Behavior Case Reports - March 16, 2019 Category: Neurology Source Type: research

Retention Rate of First Antiepileptic Drug in Poststroke Epilepsy: a Nationwide Study
ConclusionsLamotrigine and levetiracetam have higher retention rates than carbamazepine in poststroke epilepsy. This is in agreement with existing small RCTs in this patient group.
Source: Seizure - November 24, 2018 Category: Neurology Source Type: research

AEDs after ICH: Preventing the prophylaxis
Has the routine use of antiepileptic drugs (AEDs) in intracerebral hemorrhage (ICH) become a habit too difficult to break? Adherents to evidence-based medicine must surely have a conniption in light of this continuing practice. The guidelines have remained clear over the years: Do not use antiseizure medications in ICH unless there has been a seizure. Yet prophylactic AED use after acute ICH remains widespread in the United States. This is brought to our attention in the current issue of Neurology®. Naidech et al.1 report on the patterns of AED use in ICH over 5 years across several academic medical centers in Chicago....
Source: Neurology - December 25, 2016 Category: Neurology Authors: Koch, S., Sung, G. Tags: Critical care, Antiepileptic drugs, Intracerebral hemorrhage EDITORIALS Source Type: research

A systematic review of epileptic seizures in adults with subdural haematomas
Conclusions PTS are a serious complication in patients with SDH, particularly in aSDH. The “prophylactic use” of antiepileptic drugs might be beneficial in patients with cumulative risk factors.
Source: Seizure - November 24, 2016 Category: Neurology Source Type: research

Nursing Home Residents with Seizure Disorders/Epilepsy: Prevalence, Characteristics, and Treatment Patterns (P1.080)
Conclusions: NHRs with seizure disorder/epilepsy have substantial physical and cognitive impairment. Nearly half were prescribed combination AED therapy, and >20[percnt] took 蠅3 different AEDs, suggesting refractory epilepsy. Additional research is needed to assess treatment outcomes and further define optimal care in this population.Disclosure: Dr. Zarowitz has nothing to disclose. Dr. Allen has nothing to disclose. Dr. OShea has nothing to disclose. Dr. Wang has nothing to disclose. Dr. Semenchuk has nothing to disclose. Dr. Barghout has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Zarowitz, B., Allen, C., OShea, T., Wang, Z., Semenchuk, M., Barghout, V. Tags: Epilepsy/Clinical Neurophysiology: Geriatric Epilepsy, Epidemiology, and Health Services Source Type: research

Efficacy of phenytoin, valproic acid, carbamazepine and new antiepileptic drugs on control of late‐onset post‐stroke epilepsy in Taiwan
ConclusionsThis large nationwide, population‐based study demonstrated that late‐onset post‐stroke epilepsy patients using VPA and new AEDs have better seizure control than those using PHT as demonstrated by lower risks of ER visits and hospitalization.
Source: European Journal of Neurology - July 1, 2015 Category: Neurology Authors: Y.‐H. Huang, N.‐F. Chi, Y.‐C. Kuan, L. Chan, C.‐J. Hu, H.‐Y. Chiou, L.‐N. Chien Tags: Original Article Source Type: research

Prevalence, type of epilepsy and use of antiepileptic drugs in primary care.
CONCLUSIONS: The prevalence of patients with epilepsy was 8.4/1000 inhabitants, most frequent etiology the symptomatic focal stroke. More than half of patients suffered neurological and/or psychiatric comorbidity. At the end of follow-up the great majority were seizure-free without adverse effects of the antiepileptic drug treatment. PMID: 26062825 [PubMed - in process]
Source: Revista de Neurologia - June 13, 2015 Category: Neurology Authors: Fernandez-Suarez E, Villa-Estebanez R, Garcia-Martinez A, Fidalgo-Gonzalez JA, Zanabili Al-Sibbai AA, Salas-Puig J Tags: Rev Neurol Source Type: research

Antiepileptic Drug Prescribing for OEF/OIFVeterans with New-Onset Epilepsy: 2008-2010 (S59.004)
CONCLUSIONS: Our examination of prescribing patterns found that slightly over half of individuals with new epilepsy were treated using newer AEDs and 94% received monotherapy. Despite lack of FDA approval or recommendation by the AES, AAN or the ILAE for the use of levetiracetam monotherapy in the treatment of new onset epilepsy, levetiracetam monotherapy was the most common single medication prescribed. Moreover, nearly 40% of women in childbearing age received valproate or topiramate, which have been identified as teratogenic. Further research is needed to evaluate the quality of prescribing for women.Study Supported by:...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Pugh, M. J., Van Cott, A., Baca, C., Amuan, M. Tags: Epilepsy and Clinical Neurophysiology (EEG): Reproduction, Health Care Delivery, and Co-morbidities Source Type: research

Antiepileptic Drug Prescribing for OEF/OIFVeterans with New-Onset Epilepsy: 2008-2010 (I8-1.009)
CONCLUSIONS: Our examination of prescribing patterns found that slightly over half of individuals with new epilepsy were treated using newer AEDs and 94% received monotherapy. Despite lack of FDA approval or recommendation by the AES, AAN or the ILAE for the use of levetiracetam monotherapy in the treatment of new onset epilepsy, levetiracetam monotherapy was the most common single medication prescribed. Moreover, nearly 40% of women in childbearing age received valproate or topiramate, which have been identified as teratogenic. Further research is needed to evaluate the quality of prescribing for women.Study Supported by:...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Pugh, M. J., Van Cott, A., Baca, C., Amuan, M. Tags: Clinical Decision Making After the Dust Settles on Clinical Trials Poster Presentations Source Type: research

Epilepsy and Cancer: Ancient Problem in a Top Mortality Illness (P3.313)
CONCLUSIONS: Seizures in patients with cancer is a frequent comorbid condition with a high mortality rate, further studies are required to study the efficacy and security of AED and other forms of treatment.Study Supported by: NoneDisclosure: Dr. Cacho Diaz has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Cacho Diaz, B. Tags: Neurologic Complications of Cancer Source Type: research

Paroxysmal Dysarthria and Ataxia after Treatment of Brainstem Encephalitis (P6.053)
CONCLUSIONS: Paroxysmal dysarthria and ataxia is most often recognized as a complication of multiple sclerosis, but it can occur in other neurologic diseases with midbrain lesions near or involving the red nucleus. Effective treatments include carbamazepine, acetazolamide, lamotrigine, and phenytoin.Study Supported by: N/A.Disclosure: Dr. Klaas has nothing to disclose. Dr. Boes has nothing to disclose. Dr. Aksamit has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Klaas, J., Boes, C., Aksamit, A. Tags: Movement Disorders: Miscellaneous Ataxias Source Type: research

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