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β-Estradiol and progesterone enhance biofilm development and persister cell formation in monospecies and microcosms biofilms derived from vulvovaginal candidiasis
Biofouling. 2023 Sep 12:1-11. doi: 10.1080/08927014.2023.2256674. Online ahead of print.ABSTRACTThe present study aimed to: (1) evaluate the influence of the steroid hormones (SH) on biofilm development; (2) investigate the formation of persister cells (PC) in biofilms; and (3) investigate the influence of SH on PC formation. Biofilms were derived from vulvovaginal candidiasis (VVC) samples and evaluated by three models: microcosm biofilms grown in Vaginal Fluid Simulator Medium (MiB-VFSM); monospecies biofilms grown in VFSM (MoB-VFSM) and RPMI media (MoB-RPMI). SH altered cell counting and biomass of biofilms grown in VSF...
Source: Biofouling - September 12, 2023 Category: Molecular Biology Authors: Ana Raquel Colares de Andrade M ônica Dantas Sampaio Rezende Fernando Victor Monteiro Portela Livia Maria Galdino Pereira Bruno Nascimento da Silva Reginaldo Gon çalves de Lima-Neto Marcos F ábio Gadelha Rocha Jos é Júlio Costa Sidrim D ébora Souza Source Type: research

Pyridoxamine protects human granulosa cells against advanced glycation end-products-induced steroidogenesis disturbances
CONCLUSION: This study indicates that hormonal dysfunctions induced by the AGEs-RAGE axis in luteinized GCs are likely rectified by PM treatment. This effect is likely acquired by reduced expression of RAGE. A better understanding of how AGEs and PM interact in ovarian physiology and pathology may lead to more targeted therapy for treating ovarian dysfunction.PMID:37642758 | DOI:10.1007/s11033-023-08723-8
Source: Molecular Biology Reports - August 29, 2023 Category: Molecular Biology Authors: Maryam Mirani Soghra Bahmanpour Fatemeh Masjedi Zahra Derakhshan Mahintaj Dara Mohammad Hossein Nasr-Esfahani Seyed Mohammad Bagher Tabei Source Type: research

Oestrogen treatment restores dentate gyrus development in premature newborns by IGF1 regulation
J Cell Mol Med. 2023 Aug 18. doi: 10.1111/jcmm.17816. Online ahead of print.ABSTRACTPrematurely-born infants cared for in the neonatal units suffer from memory and learning deficits. Prematurity diminishes neurogenesis and synaptogenesis in the hippocampal dentate gyrus (DG). This dysmaturation of neurons is attributed to elevated PSD95, NMDR2A, and IGF1 levels. Since oestrogen treatment plays key roles in the development and plasticity of DG, we hypothesized that 17β-estradiol (E2) treatment would ameliorate neurogenesis and synaptogenesis in the DG, reversing cognitive deficits in premature newborns. Additionally, E2-in...
Source: J Cell Mol Med - August 18, 2023 Category: Molecular Biology Authors: Deep R Sharma Bokun Cheng Rauhin Sahu Xusheng Zhang Rana Mehdizadeh Divya Singh Dumitru Iacobas Praveen Ballabh Source Type: research

Estrogen receptor α-mediated signaling inhibits type I interferon response to promote breast cancer
In this study, we show that ERα is a negative regulator of type I interferon (IFN) response, which is critical for breast carcinogenesis. Activation of ERα by its natural ligand estradiol inhibits IFN-β-induced transcription of downstream IFN-stimulated genes (ISGs), whereas deficiency of ERα or stimulation with its antagonist fulvestrant has opposite effects. Mechanistically, ERα inhibits type I IFN response by two distinct mechanisms. ERα induces expression of the histone 2A variant H2A.Z, which restricts engagement of the IFN-stimulated gene factor 3 (ISGF3) complex at the ISG promoters. ERα also interacts with S...
Source: Mol Biol Cell - July 13, 2023 Category: Molecular Biology Authors: Li-Bo Cao Zi-Lun Ruan Yu-Lin Yang Nian-Chao Zhang Chuan Gao Cheguo Cai Jing Zhang Ming-Ming Hu Hong-Bing Shu Source Type: research

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