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Estrogen receptor and immune checkpoint inhibitors: new partners in lung cancer?
Clin Cancer Res. 2023 Aug 7:CCR-23-1736. doi: 10.1158/1078-0432.CCR-23-1736. Online ahead of print.ABSTRACTThe influence of sex on immunotherapy response in NSCLC patients had been studied with no clear conclusions. An article in this issue reports that a key determinant of response is not sex but the existence of a 17-β-estradiol/ERα/PDL1 signaling loop in NSCLC. This intriguing result opens new therapeutic options.PMID:37548629 | DOI:10.1158/1078-0432.CCR-23-1736
Source: Clinical Cancer Research - August 7, 2023 Category: Cancer & Oncology Authors: Karmele Valencia Luis M Montuenga Alfonso Calvo Source Type: research

Autocrine 17- β-estradiol/estrogen receptor-α loop determines the response to immune-checkpoint inhibitors in non-small cell lung cancer
CONCLUSIONS: Our work unveils that 17-β-estradiol/ERα status predicts the response to pembrolizumab in NSCLC patients. Secondly, we propose aromatase inhibitors as new gender-tailored immune-adjuvants in NSCLC.PMID:37285115 | DOI:10.1158/1078-0432.CCR-22-3949
Source: Clinical Lung Cancer - June 7, 2023 Category: Cancer & Oncology Authors: Dario P Anobile Iris C Salaroglio Fabrizio Tabb ò Sofia La Vecchia Muhlis Akman Francesca Napoli Maristella Bungaro Federica Benso Elisabetta Aldieri Paolo Bironzo Joanna Kopecka Francesco Passiglia Luisella Righi Silvia Novello Giorgio V Scagliotti Chia Source Type: research

Fight Aging! Newsletter, January 16th 2023
Conclusions Implanted Hair Follicle Cells Produce Remodeling of Scar Tissue Assessment of Somatic Mosaicism as a Biomarker of Aging The Gut Microbiome of Centenarians https://www.fightaging.org/archives/2023/01/the-gut-microbiome-of-centenarians/ The state of the gut microbiome is arguably as influential on health as exercise. Various microbial species present in the gut produce beneficial metabolites, such as butyrate, or harmful metabolites, such as isoamylamine, or can provoke chronic inflammation in a variety of ways. An individual can have a better or worse microbiome, assessing these and other fu...
Source: Fight Aging! - January 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Multifaceted Biology of PCSK9
This article reviews the discovery of PCSK9, its structure-function characteristics, and its presently known and proposed novel biological functions. The major critical function of PCSK9 deduced from human and mouse studies, as well as cellular and structural analyses, is its role in increasing the levels of circulating low-density lipoprotein (LDL)-cholesterol (LDLc), via its ability to enhance the sorting and escort of the cell surface LDL receptor (LDLR) to lysosomes. This implicates the binding of the catalytic domain of PCSK9 to the EGF-A domain of the LDLR. This also requires the presence of the C-terminal Cys/His-ri...
Source: ENDOCR REV - May 13, 2022 Category: Endocrinology Authors: Nabil G Seidah Annik Prat Source Type: research

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