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Chinese medicinal herbs for reducing endocrine therapy-induced side effects in patients with hormone receptor-positive breast cancer: a systematic review and meta-analysis
CONCLUSIONS: CMH combined with complementary therapy can moderately reduce endocrine therapy-induced side effects, including bone loss and dyslipidemia in patients with HR + breast cancer, revealing the potential role of CMH in treating (HR+) breast cancer. More high-quality RCTs are warranted to further validate the effectiveness and safety of CMH.PMID:37096936 | PMC:PMC10132232 | DOI:10.1080/13880209.2023.2203193
Source: Pharmaceutical Biology - April 25, 2023 Category: Drugs & Pharmacology Authors: Shaoqing Chen Yifang Gao Haichao Liu Jin Jing Zhengyu Yang Haoming Zhu Bairui Chen Yu Wang Ting Zhang Shizhong Wang Jianping Lin Source Type: research
Efficacy and safety of Gushen Antai Pills combined with dydrogesterone in the treatment of threatened miscarriage: a systematic review and meta-analysis
Conclusion: The overall available evidence suggested that Gushen Antai Pills combined with dydrogesterone had significant effects in improving pregnancy success rate, clinical symptoms and hormone levels for women with threatened miscarriage, with considerable safety and reliability. However, due to the partial heterogeneity, suboptimal quality and high risk of bias of some included studies, further rigorously designed randomized controlled trials are required.Systematic Review Registration: identifier https://INPLASY2022120035, https://inplasy.com/inplasy-2022-12-0035/.
Source: Frontiers in Pharmacology - June 2, 2023 Category: Drugs & Pharmacology Source Type: research
Machine learning identifies ferroptosis-related genes as potential diagnostic biomarkers for osteoarthritis
ConclusionWe identify 4 FRGs (AQP8, BRD7, IFNA4, and ARHGEF26-AS1) closely associated with bio-oxidative stress and immune response, which may become early diagnostic and therapeutic targets for OA.
Source: Frontiers in Endocrinology - June 12, 2023 Category: Endocrinology Source Type: research
Biodegradation of 17 β-estradiol by < em > Serratia marcescens < /em > and < em > Stenotrophomonas tumulicola < /em > co-culture isolated from a sewage treatment plant in Upper Egypt
CONCLUSION: This study detected new bacterial strains that are capable of rapid degradation of estrogen as an environmental pollutant.PMID:37448674 | PMC:PMC10336294 | DOI:10.18502/ijm.v15i3.12906
Source: Iranian Journal of Microbiology - July 14, 2023 Category: Microbiology Authors: Ibrahim Mahmoud Ali Hamada Mohamed Mohamed Halby Bahaa-Eldin Anwar Abd-Elrady Mohamed Taha Salim Heba Ahmed Mohamed Source Type: research
