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IVF characteristics and the molecular luteal features of random start IVF cycles are not different from conventional cycles in cancer patients
Hum Reprod. 2022 Nov 11:deac242. doi: 10.1093/humrep/deac242. Online ahead of print.ABSTRACTSTUDY QUESTION: Are the IVF parameters and the steroidogenic luteal characteristics of random-start IVF cycles different from conventional cycles in cancer patients?SUMMARY ANSWER: No; controlled ovarian stimulation cycles randomly started at late follicular phase (LFP) and luteal phase (LP) are totally comparable to those conventional IVF cycles started at early follicular phase (EFP) in terms of the expression of the enzymes involved in cholesterol utilization and steroid hormone biosynthesis pathways, gonadotropin receptor expres...
Source: Cancer Control - November 11, 2022 Category: Cancer & Oncology Authors: Yashar Esmaeilian Francesko Hela Gamze Bildik Nazli Akin Ece İltumur Sevgi Yusufoglu Ceren Sultan Yildiz İpek Keles Dogan Vatansever Cagatay Taskiran Kayhan Yakin Ozgur Oktem Source Type: research

Guideline No. 425a: Cannabis Use Throughout Women's Lifespans - Part 1: Fertility, Contraception, Menopause, and Pelvic Pain
J Obstet Gynaecol Can. 2022 Apr;44(4):407-419.e4. doi: 10.1016/j.jogc.2022.01.012.ABSTRACTOBJECTIVE: To provide health care providers with the best evidence on cannabis use with respect to women's health. Areas of focus include general patterns of cannabis use as well as safety of use; care for women who use cannabis; stigma; screening, brief intervention, and referral to treatment; impact on hormonal regulation; reproductive health, including contraception and fertility; sexual function; effects on perimenopausal and menopausal symptoms; and use in chronic pelvic pain syndromes.TARGET POPULATION: The target population inc...
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - April 11, 2022 Category: OBGYN Authors: Magali Robert Lisa E Graves Victoria M Allen Sumeet Dama Robert L Gabrys Robert L Tanguay Suzanne D Turner Courtney R Green Jocelynn L Cook Source Type: research

Fight Aging! Newsletter, July 22nd 2019
This study elucidates the potential to use mitochondria from different donors (PAMM) to treat UVR stress and possibly other types of damage or metabolic malfunctions in cells, resulting in not only in-vitro but also ex-vivo applications. Gene Therapy in Mice Alters the Balance of Macrophage Phenotypes to Slow Atherosclerosis Progression https://www.fightaging.org/archives/2019/07/gene-therapy-in-mice-alters-the-balance-of-macrophage-phenotypes-to-slow-atherosclerosis-progression/ Atherosclerosis causes a sizable fraction of all deaths in our species. It is the generation of fatty deposits in blood vessel...
Source: Fight Aging! - July 21, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

17 {beta}-Estradiol promotes vascular endothelial growth factor expression via the Wnt/{beta}-catenin pathway during the pathogenesis of endometriosis
STUDY HYPOTHESIS Do estrogen and Wnt/β-catenin signaling promote vascular endothelial growth factor (VEGF) expression in endometriosis and how? STUDY FINDING 17β-Estradiol (E2)-drives β-catenin triggered up-regulation of VEGF in effector human primary endometrial stromal cells (ESCs) and thus enhances their ability to establish a new blood supply to the human exfoliated endometrium. WHAT IS KNOWN ALREADY Implantation and survival of exfoliated endometrium is crucially dependent on neovascularization and Wnt/β-catenin signaling plays an important role in stimulating angiogenesis. STUDY DESIGN, SAMPLES...
Source: Molecular Human Reproduction - July 11, 2016 Category: Molecular Biology Authors: Zhang, L., Xiong, W., Xiong, Y., Liu, H., Liu, Y. Tags: Original Research Source Type: research

Ovarian responsiveness in women receiving fertility treatment after methotrexate for ectopic pregnancy: a systematic review and meta-analysis
STUDY QUESTION Does previous methotrexate (MTX) treatment for ectopic pregnancy (EP) have an effect on ovarian response in women receiving fertility treatment? SUMMARY ANSWER MTX treatment for EP does not seem to affect subsequent fertility treatment. WHAT IS KNOWN ALREADY MTX is commonly used to treat EPs that are diagnosed early. Previous studies have reported conflicting results about its effect on subsequent fertility treatments. STUDY DESIGN, SIZE, DURATION This systematic review and meta-analysis included a total of 329 patients who had participated in 7 observational studies. PARTICIPANTS/MATERIALS, SETTING, MET...
Source: Human Reproduction - August 13, 2014 Category: Reproduction Medicine Authors: Ohannessian, A., Loundou, A., Courbiere, B., Cravello, L., Agostini, A. Tags: Infertility Source Type: research

MicroRNA Let-7a and dicer are important in the activation and implantation of delayed implanting mouse embryos
STUDY QUESTION Does Let-7a have a functional role in modulating dicer expression to activate dormant mouse blastocysts for implantation? SUMMARY ANSWER Let-7a post-transcriptionally regulates dicer expression altering microRNA expression to affect the implantation competency of the activated blastocysts. WHAT IS KNOWN ALREADY The Let-7a microRNA is up-regulated during blastocyst dormancy and its forced-expression suppresses embryo implantation in vitro and in vivo. Dicer is a Let-7 target, which processes pre-microRNA to mature microRNA. STUDY DESIGN, SIZE, DURATION The effects on the expression of Let-7a and dicer in d...
Source: Human Reproduction - March 11, 2014 Category: Reproduction Medicine Authors: Cheong, A. W. Y., Pang, R. T. K., Liu, W.-M., Kottawatta, K. S. A., Lee, K.-F., Yeung, W. S. B. Tags: Reproductive biology Source Type: research

Cycle cancellation and pregnancy after luteal estradiol priming in women defined as poor responders: a systematic review and meta-analysis
STUDY QUESTION Does a luteal estradiol (LE) stimulation protocol improve outcomes in poor responders to IVF? SUMMARY ANSWER LE priming is associated with decreased cycle cancellation and increased chance of clinical pregnancy in poor responders WHAT IS KNOWN ALREADY Poor responders to IVF are one of the most challenging patient populations to treat. Many standard protocols currently exist for stimulating these patients but all have failed to improve outcomes. STUDY DESIGN, SIZE, DURATION Systematic review and meta-analysis including eight published studies comparing assisted reproduction technology (ART) outcomes in poo...
Source: Human Reproduction - October 11, 2013 Category: Reproduction Medicine Authors: Reynolds, K. A., Omurtag, K. R., Jimenez, P. T., Rhee, J. S., Tuuli, M. G., Jungheim, E. S. Tags: Infertility Source Type: research