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Total 129 results found since Jan 2013.
Proteomic Atlas of Atherosclerosis: The Contribution of Proteoglycans to Sex Differences, Plaque Phenotypes, and Outcomes
CONCLUSIONS: Plaque proteomics redefined clinically relevant patient groups with distinct outcomes, identifying subgroups of male and female patients with elevated risk of future cardiovascular events.PMID:37646165 | DOI:10.1161/CIRCRESAHA.123.322590
Source: Circulation Research - August 30, 2023 Category: Cardiology Authors: Konstantinos Theofilatos Stefan Stojkovic Maria Hasman Sander W van der Laan Ferheen Baig Javier Barallobre-Barreiro Lukas Schmidt Siqi Yin Xiaoke Yin Sean Burnap Bhawana Singh Jude Popham Olesya Harkot Stephanie Kampf Maja Carina Nackenhorst Andreas Stra Source Type: research
Oestrogen treatment restores dentate gyrus development in premature newborns by IGF1 regulation
J Cell Mol Med. 2023 Aug 18. doi: 10.1111/jcmm.17816. Online ahead of print.ABSTRACTPrematurely-born infants cared for in the neonatal units suffer from memory and learning deficits. Prematurity diminishes neurogenesis and synaptogenesis in the hippocampal dentate gyrus (DG). This dysmaturation of neurons is attributed to elevated PSD95, NMDR2A, and IGF1 levels. Since oestrogen treatment plays key roles in the development and plasticity of DG, we hypothesized that 17β-estradiol (E2) treatment would ameliorate neurogenesis and synaptogenesis in the DG, reversing cognitive deficits in premature newborns. Additionally, E2-in...
Source: J Cell Mol Med - August 18, 2023 Category: Molecular Biology Authors: Deep R Sharma Bokun Cheng Rauhin Sahu Xusheng Zhang Rana Mehdizadeh Divya Singh Dumitru Iacobas Praveen Ballabh Source Type: research
Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo.
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Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/
It seems...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Emotion recognition and mood along the menstrual cycle
Horm Behav. 2023 Jul 19;154:105406. doi: 10.1016/j.yhbeh.2023.105406. Online ahead of print.ABSTRACTPrevious studies have demonstrated menstrual cycle dependent changes in the recognition of facial emotional expressions, specifically the expression of fear, anger, sadness or disgust. While some studies demonstrate an improvement of emotion recognition performance during the peri-ovulatory phase, when estradiol levels peak, other studies demonstrate a deterioration of emotion recognition performance during the mid-luteal phase, when progesterone levels peak. It has been hypothesized, that these changes in emotion recognitio...
Source: Hormones and Behavior - July 21, 2023 Category: Endocrinology Authors: Belinda Pletzer Isabel Noachtar Source Type: research
