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Drug: Metformin

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Total 9821 results found since Jan 2013.

Association of Metformin Use During Hospitalization and Mortality in Critically Ill Adults With Type 2 Diabetes Mellitus and Sepsis*
CONCLUSIONS: Metformin exposure during hospitalization is associated with a decrease in 90-day mortality in patients with type 2 diabetes mellitus and sepsis.
Source: Critical Care Medicine - May 27, 2022 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

What factors influence protein synthesis and degradation in critical illness?
Purpose of review: The optimal approach to improve protein metabolism in critical illness is not yet fully defined. Here, we have summarized recent literature dealing with the main catabolic and anabolic factors influencing protein kinetics in acute hypercatabolic patients. Recent findings: Protein/amino acid intake levels should be adapted to type and severity of illness, keeping in mind that energy overfeeding is associated with poor outcome. A number of anticatabolic nutraceuticals and drugs have been tested in acute patients. The encouraging results have been obtained with β-hydroxy-β-methylbutyrate, omega-3 fatty a...
Source: Current Opinion in Clinical Nutrition and Metabolic Care - February 2, 2017 Category: Nutrition Tags: NUTRITION AND THE INTENSIVE CARE UNIT: Edited by Peter Weijs and Stephen A. McClave Source Type: research

Severe lactic acidosis and hypoglycemia due to acute metformin intoxication in a dog
Journal of Veterinary Emergency and Critical Care, EarlyView.
Source: Journal of Veterinary Emergency and Critical Care - April 24, 2018 Category: Veterinary Research Authors: YuUedaDVM, DACVECC , ChristineWongDVM, DACVECC , AngelaBorchersDVM, DACVECC, DACVIM Source Type: research

Association between metformin use on admission and outcomes in intensive care unit patients with acute kidney injury and type 2 diabetes: A retrospective cohort study
Publication date: Available online 24 December 2020Source: Journal of Critical CareAuthor(s): Qilin Yang, Jiezhao Zheng, Deliang Wen, Xiaohua Chen, Weiyan Chen, Weixiao Chen, Xuming Xiong, Zhenhui Zhang
Source: Journal of Critical Care - December 25, 2020 Category: Gastroenterology Source Type: research

Metformin use may be associated with reduced risk-adjusted mortality in patients with AKI and diabetes in the ICU: If associated with lactic acidosis, especially in shocked patients, we need to eliminate it as quickly as possible through RRT!
Publication date: October 2021Source: Journal of Critical Care, Volume 65Author(s): Patrick M. Honore, Sebastien Redant, Thierry Preseau, Sofie Moorthamers, Keitiane Kaefer, Leonel Barreto Gutierrez, Rachid Attou, Andrea Gallerani, David De Bels
Source: Journal of Critical Care - July 10, 2021 Category: Gastroenterology Source Type: research

The majority of type 2 diabetic patients in Finnish primary care are at very high risk of cardiovascular events: A cross-sectional chart review study (STONE HF)
CONCLUSIONS: The majority of T2D patients in Finnish primary care are at very high risk of cardiovascular events. However, the implementation of treatments with proven cardioprotective effects in very high-risk patients is currently suboptimal.PMID:34972659 | DOI:10.1016/j.pcd.2021.12.012
Source: Primary Care - January 1, 2022 Category: Primary Care Authors: Kaj Mets ärinne Mikko Pietil ä Ilkka Kantola Lotta K Stenman Olli-Pekka H ätinen Aino Vesikansa Tuija Poussa Leo Niskanen STONE HF (STatus Of kidNEy disease in type 2 diabetes and heart failure in Finnish primary care) study investigators Source Type: research

Beyond metformin: safety considerations in the decision-making process for selecting a second medication for type 2 diabetes management: reflections from a diabetes care editors' expert forum.
This article, an outgrowth of the forum, summarizes well-delineated and theoretical safety concerns related to these drug classes, as well as the panelists' opinions regarding their best use in patients with type 2 diabetes. All of the options appear to have reasonably wide safety margins when used appropriately. Those about which we know the most-metformin, SUs, insulin, and perhaps now also TZDs-are efficacious in most patients and can be placed into a basic initial algorithm. However, these agents leave some clinical needs unmet. Selecting next steps is a more formidable process involving newer agents that are understoo...
Source: Diabetes Care - August 29, 2014 Category: Endocrinology Authors: Cefalu WT, Buse JB, Del Prato S, Home PD, LeRoith D, Nauck MA, Raz I, Rosenstock J, Riddle MC Tags: Diabetes Care Source Type: research

Contacting dropouts from type 2 diabetes care in public primary health care: description of the patient population.
CONCLUSIONS: Ten percent of T2D patients were dropouts of whom those with a poor glycaemic control were younger than the other dropouts. BP and LDL cholesterol concentrations were non-optimal among the majority of the dropouts. Metformin was prescribed less frequently to the dropouts than is usual for T2D patients. The comorbidities were equally common among the dropouts as among the other T2D patients. KEY POINTS   Which kinds of patients are dropouts from type-2 diabetes care is not known. • One-tenth of the patients with T2D were dropouts and they generally had good glycaemic control. • Blood pressure and LD...
Source: Primary Care - July 11, 2016 Category: Primary Care Authors: Kauppila T, Laine MK, Honkasalo M, Raina M, Eriksson JG Tags: Scand J Prim Health Care Source Type: research

My Infertility Journey as a Woman in Medicine
Editor’s Note: For more on the challenges as well as strategies to address physician infertility, please read this Academic Medicine Invited Commentary, cowritten by the author of this blog post. Most of us in medicine pride ourselves on being organized, detail-oriented, conscientious and able to achieve excellent results with enough hard work—and are not used to failure and loss of control. My experience with infertility has been the first time that I truly experienced failure and complete loss of control, realizing that fertility is not a merit-based system. No matter how hard I try, how many doctors I cons...
Source: Academic Medicine Blog - March 11, 2020 Category: Universities & Medical Training Authors: Guest Author Tags: Featured Guest Perspective infertility physician well-being women in academic medicine Source Type: blogs

Response to Comment on: Smiechowski et al. The Use of Metformin and the Incidence of Lung Cancer in Patients With Type 2 Diabetes. Diabetes Care 2013;36:124-129.
PMID: 23431103 [PubMed - in process]
Source: Diabetes Care - February 28, 2013 Category: Endocrinology Authors: Suissa S, Azoulay L Tags: Diabetes Care Source Type: research

Comment on: Smiechowski et al. The Use of Metformin and the Incidence of Lung Cancer in Patients With Type 2 Diabetes. Diabetes Care 2013;36:124-129.
PMID: 23431102 [PubMed - in process]
Source: Diabetes Care - February 28, 2013 Category: Endocrinology Authors: Lai SW, Liao KF Tags: Diabetes Care Source Type: research

Response to yang and chan. Metformin and the risk of cancer: time-related biases in observational studies. Diabetes care 2012;35:2665-2673.
PMID: 23704696 [PubMed - in process]
Source: Diabetes Care - May 29, 2013 Category: Endocrinology Authors: Suissa S, Azoulay L Tags: Diabetes Care Source Type: research