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Serum 25-Hydroxy Vitamin D: A Predictor of Macrovascular and Microvascular Complications in Patients With Type 2 Diabetes.
CONCLUSIONS: Low blood 25OH-D concentrations are associated with an increased risk of macrovascular and microvascular disease events in type 2 diabetes. However, a causal link remains to be demonstrated. PMID: 25524951 [PubMed - as supplied by publisher]
Source: Diabetes Care - December 18, 2014 Category: Endocrinology Authors: Herrmann M, Sullivan DR, Veillard A, McCorquodale T, Straub IR, Scott R, Laakso M, Topliss D, Jenkins AJ, Blankenberg S, Burton A, Keech AC, for the FIELD study investigators Tags: Diabetes Care Source Type: research

Favourable effects of fenofibrate on lipids and cardiovascular disease in women with type 2 diabetes: results from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study
Conclusions/interpretation Fenofibrate improved the lipoprotein profile more in women than men. Cardiovascular event reductions with fenofibrate were consistently similar in women and men, both overall and among those with low HDL-cholesterol and high triacylglycerol levels. These data provide reassurance about fenofibrate efficacy in women and men. Both sexes with type 2 diabetes should be considered for fenofibrate therapy for cardioprotection.
Source: Diabetologia - October 1, 2014 Category: Endocrinology Source Type: research

Recovery of brain biomarkers following peroxisome proliferator-activated receptor agonist neuroprotective treatment before ischemic stroke
Conclusions: Pre-treatment with PPARalpha agonist or atorvastatin show potential neuroprotective effects by inhibiting the PDI overexpression in conjunction with the preservation of other neuronal markers, several of which are associated with the regulation of protein homeostasis, signal transduction and maintenance of synaptic plasticity. This proteomic study therefore suggests that neuroprotective effect of PPARalpha agonists supposes the preservation of the expression of several proteins essential for the maintenance of protein homeostasis not necessarily directly linked to PPARalpha known-regulated targets.
Source: Proteome Science - May 6, 2014 Category: Bioinformatics Authors: Patrick GeléValérie VingtdeuxCamille PoteyHervé DrobecqAntoine GhestemPatricia MelnykLuc BuéeNicolas SergeantRégis Bordet Source Type: research

Outcomes of Combined Cardiovascular Risk Factor Management Strategies in Type 2 Diabetes: The ACCORD Randomized Trial.
CONCLUSIONSIn the ACCORD BP trial, compared with combined standard treatment, intensive BP or intensive glycemia treatment alone improved major CVD outcomes, without additional benefit from combining the two. In the ACCORD lipid trial, neither intensive lipid nor glycemia treatment produced an overall benefit, but intensive glycemia treatment increased mortality. PMID: 24595629 [PubMed - as supplied by publisher]
Source: Diabetes Care - March 4, 2014 Category: Endocrinology Authors: Margolis KL, O'Connor PJ, Morgan TM, Buse JB, Cohen RM, Cushman WC, Cutler JA, Evans GW, Gerstein HC, Grimm RH, Lipkin EW, Venkat Narayan KM, Riddle MC, Sood A, Goff DC Tags: Diabetes Care Source Type: research

Abstract 298: Fibrate use in patients with type 2 diabetes Poster Session III
In conclusion, the prevalence of atherogenic dyslipidemia among patients with type 2 diabetes has increased significantly over the past decade. However, fibrate use in all patients with type 2 diabetes, including those specifically with atherogenic dyslipidemia, has remained constant throughout the observation period, despite lack of conclusive evidence supporting its use.
Source: Circulation: Cardiovascular Quality and Outcomes - May 15, 2013 Category: Cardiology Authors: McCoy, R. G., Van Houten, H. K., Shah, N. D. Tags: Poster Session III Source Type: research

Rates and predictors of risk of stroke and its subtypes in diabetes: a prospective observational study
Conclusions Older people with a history of stroke were at highest risk of stroke, but the prognosis and prognostic factors of subtypes were heterogeneous. The results will help clinicians quantify the absolute risk of stroke and its subtypes for typical diabetes patients.
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 15, 2013 Category: Neurosurgery Authors: Hankey, G. J., Anderson, N. E., Ting, R.-D., Veillard, A.-S., Romo, M., Wosik, M., Sullivan, D. R., O'Connell, R. L., Hunt, D., Keech, A. C. Tags: Stroke, Hypertension, Ophthalmology, Ischaemic heart disease Cerebrovascular disease Source Type: research

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