Filtered By:
Specialty: Molecular Biology
Drug: Temodar
This page shows you your search results in order of date.
Order by Relevance | Date
Total 43 results found since Jan 2013.
Next-generation bromodomain inhibitors of the SWI/SNF complex enhance DNA damage and cell death in glioblastoma
J Cell Mol Med. 2023 Aug 18. doi: 10.1111/jcmm.17907. Online ahead of print.ABSTRACTGlioblastoma (GBM) is an aggressive brain cancer with a poor prognosis. While surgical resection is the primary treatment, adjuvant temozolomide (TMZ) chemotherapy and radiotherapy only provide slight improvement in disease course and outcome. Unfortunately, most treated patients experience recurrence of highly aggressive, therapy-resistant tumours and eventually succumb to the disease. To increase chemosensitivity and overcome therapy resistance, we have modified the chemical structure of the PFI-3 bromodomain inhibitor of the BRG1 and BRM...
Source: J Cell Mol Med - August 18, 2023 Category: Molecular Biology Authors: Chuanhe Yang Yali He Yinan Wang Peter J McKinnon Vijay Shahani Duane D Miller Lawrence M Pfeffer Source Type: research
The role of PKN1 in glioma pathogenesis and the antiglioma effect of raloxifene targeting PKN1
J Cell Mol Med. 2023 Jul 21. doi: 10.1111/jcmm.17860. Online ahead of print.ABSTRACTPKN1 (protein kinase N1), a serine/threonine protein kinase family member, is associated with various cancers. However, the role of PKN1 in gliomas has rarely been studied. We suggest that PKN1 expression in glioma specimens is considerably upregulated and positively correlates with the histopathological grading of gliomas. Knocking down PKN1 expression in glioblastoma (GBM) cells inhibits GBM cell proliferation, invasion and migration and promotes apoptosis. In addition, yes-associated protein (YAP) expression, an essential effector of the...
Source: Molecular Medicine - July 22, 2023 Category: Molecular Biology Authors: Yubing Hao Zelin Li Anling Zhang Li Sun Guangxiu Wang Hu Wang Zhifan Jia Source Type: research
Circ < em > TTLL13 < /em > Promotes TMZ Resistance in Glioma via Modulating < em > OLR1 < /em > -Mediated Activation of the Wnt/ β-Catenin Pathway
This study offers an insight into the efficacy improvement of TMZ for glioma treatment.PMID:37427890 | DOI:10.1080/10985549.2023.2210032
Source: Mol Biol Cell - July 10, 2023 Category: Molecular Biology Authors: Jun Li Junfeng Ma Shan Huang Jun Li Liang Zhou Jiahua Sun Lin Chen Source Type: research
Multidisciplinary docking, kinetics and X-ray crystallography studies of baicalein acting as a glycogen phosphorylase inhibitor and determination of its' potential against glioblastoma in cellular models
Chem Biol Interact. 2023 Jun 3:110568. doi: 10.1016/j.cbi.2023.110568. Online ahead of print.ABSTRACTGlycogen phosphorylase (GP) is the rate-determining enzyme in the glycogenolysis pathway. Glioblastoma (GBM) is amongst the most aggressive cancers of the central nervous system. The role of GP and glycogen metabolism in the context of cancer cell metabolic reprogramming is recognised, so that GP inhibitors may have potential treatment benefits. Here, baicalein (5,6,7-trihydroxyflavone) is studied as a GP inhibitor, and for its effects on glycogenolysis and glioblastoma at the cellular level. The compound is revealed as a p...
Source: Chemico-Biological Interactions - June 5, 2023 Category: Molecular Biology Authors: Rachel T Mathomes Symeon M Koulas Ioannis Tsialtas George Stravodimos Philip J Welsby Anna-Maria G Psarra Izabela Stasik Demetres D Leonidas Joseph M Hayes Source Type: research
Modeling glioblastoma complexity with organoids for personalized treatments
Trends Mol Med. 2023 Feb 15:S1471-4914(23)00016-3. doi: 10.1016/j.molmed.2023.01.002. Online ahead of print.ABSTRACTGlioblastoma (GBM) remains a fatal diagnosis despite the current standard of care of maximal surgical resection, radiation, and temozolomide (TMZ) therapy. One aspect that impedes drug development is the lack of an appropriate model representative of the complexity of patient tumors. Brain organoids derived from cell culture techniques provide a robust, easily manipulatable, and high-throughput model for GBM. In this review, we highlight recent progress in developing GBM organoids (GBOs) with a focus on gener...
Source: Molecular Medicine - February 22, 2023 Category: Molecular Biology Authors: Kristen D Raue Joseph T Duffy Maria V Babak Irina V Balyasnikova Source Type: research
