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Specialty: Pathology
Drug: Temodar
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Total 67 results found since Jan 2013.
Exosomes released from U87 glioma cells treated with curcumin and/or temozolomide produce apoptosis in naive U87 cells
In conclusion, we showed for the first time that exosomes released from drug-treated U87 cells could be a new therapeutic approach in glioblastoma, and could reduce the side effects produced by drugs alone. This concept needs to be further examined in animal models before clinical trials could be considered.PMID:37028110 | DOI:10.1016/j.prp.2023.154427
Source: Pathology, Research and Practice - April 7, 2023 Category: Pathology Authors: Seyed Mojtaba Mousavi Saereh Hosseindoost Seyed Mohammad Amin Mahdian Nasim Vousooghi Ali Rajabi Ameneh Jafari Amirreza Ostadian Michael R Hamblin MahmoudReza Hadjighassem Hamed Mirzaei Source Type: research
Bioinformatics analysis identified RGS4 as a potential tumor promoter in glioma
In conclusion, RGS4 may be a key protein-coding gene in glioma. RGS4 should therefore be studied further to verify its feasibility and effectiveness as a potential glioma biomarker and therapeutic target.PMID:36423402 | DOI:10.1016/j.prp.2022.154225
Source: Pathology, Research and Practice - November 24, 2022 Category: Pathology Authors: Lili Wu Jianpeng Wang Jiaojiao Zhao Ruixue Yao Qianqian Xu Leina Ma Jia Liu Source Type: research
Case Report: Clinicopathological and Genetic Features of IDH-Mutant Brainstem Glioma in Adults: Report of Five Cases
Pathol Oncol Res. 2022 Aug 4;28:1610408. doi: 10.3389/pore.2022.1610408. eCollection 2022.ABSTRACTAdult brainstem gliomas are rare central nervous system tumors that represent a heterogeneous group of tumors. Somatic IDH mutations are uncommon in adult brainstem gliomas and there are few relevant clinical studies. Here, we reported five patients with IDH1 mutations associated with brainstem gliomas, including four cases of IDH1 R132H mutations and one case of R132G mutation. All patients were treated with focal intensity-modulated radiation therapy (IMRT) with concurrent temozolomide (TMZ). One patient died, one relapsed, ...
Source: Pathology Oncology Research - August 22, 2022 Category: Pathology Authors: Jiangfen Zhou Mingyao Lai Yang Ni Shaoqun Li Junjie Zhen Furong Du Xing Zhang Chao Song Linbo Cai Source Type: research
An aggressive lactotroph pituitary tumor in a young male: A pituitary carcinoma without metastasis
Clin Neuropathol. 2022 May 16. doi: 10.5414/NP301458. Online ahead of print.ABSTRACTThis case report concerns a 31-year-old male with an aggressive pituitary tumor who presented initially with bitemporal hemianopsia and slightly elevated prolactin. On magnetic resonance imaging of the brain, there was a sellar mass with parasellar invasion to the lateral aspects of the internal carotid arteries, compressing the optic chiasm. On histopathological analysis, the diagnosis was made of a densely granulated lactotroph pituitary tumor with a Ki67 proliferation rate of 15%, a mitotic count of 6/10 high-power fields, and p53 positi...
Source: Clinical Neuropathology - May 16, 2022 Category: Pathology Authors: Friederike E Roelandt-Schumann Rob A Vergeer Astrid G W Korsten-Meijer Miranda C A Kramer Henri ëtte E Westerlaan Jan W R Pott Janine Nuver Gerrit van den Berg Wilfred F A den Dunnen Source Type: research
Rapid progression of an IDH-wild type histological low-grade glioma harbouring TERT promoter mutation and diffuse CD34 expression: a case report
In this study, we reported a novel IDH-WT glioma with histological characteristics of a low-grade tumour. Preoperative CT revealed massive calcification of this lesion and MRI showed a mixed hyperintense and hypointense signals on both T1- and T2-weighted images with a slight contrast enhancement. Micrography revealed dense deposits of calcium and diffuse microhaemorrhage in the tumour mass. Immunohistochemical staining showed diffuse expression of CD34 in neoplastic cells but uncertain positivity of glial fibrillary acidic protein (GFAP). Further sequencing found telomerase reverse transcriptase (TERT) promoter mutation i...
Source: Folia Neuropathologica - May 10, 2021 Category: Pathology Authors: Hongxiang Wang Cong Tan Tao Xu Weiqing Li Source Type: research
