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Drug: Temodar
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Total 1478 results found since Jan 2013.
Utility of Comprehensive Genomic Profiling for Precise Diagnosis of Pediatric-Type Diffuse High-Grade Glioma
In conclusion, comprehensive genetic and epigenetic analysis should be considered in pediatric brain tumor cases.PMID:37357634 | DOI:10.18926/AMO/65502
Source: Acta Med Okayama - June 26, 2023 Category: Universities & Medical Training Authors: Keigo Makino Yoshihiro Otani Kentaro Fujii Joji Ishida Shuichiro Hirano Yasuki Suruga Kana Washio Kenji Nishida Hiroyuki Yanai Shuta Tomida Daisuke Ennishi Isao Date Source Type: research
Quantitative profiling of genes associated with cancer pathways in brain tumors
CONCLUSION: Based on the obtained data, we can conclude that individual diagnoses differ in transcriptomic profile. An individual molecular approach is therefore necessary in order to provide comprehensive and targeted therapy on multiple metabolic pathways in the diagnosis of brain tumors.PMID:37353350 | DOI:10.48095/ccko2023224
Source: Cancer Control - June 23, 2023 Category: Cancer & Oncology Authors: Z Majer číková K Dibdiakov á M Galanda T Galanda R Richterov á B Kolarovszki P Ra čay J Hatok Source Type: research
Cocrystallization of lenvatinib and temozolomide to improve the performance in stability, dissolution, and tabletability
CrystEngComm, 2023, Accepted Manuscript DOI: 10.1039/D3CE00473B, PaperZhi-Qing Wang, Xia-Lin Dai, Dai-Lin Gu, Chao Wu, Tongbu Lu, Xiangtian Long, Jia-Mei Chen Two anti-melanoma drugs, lenvatinib and temozolomide, were cocrystallized to obtain two drug-drug cocrystal solvates, TMZ-LEN ·MeOH (1:1:1) and TMZ-LEN·EtOH (1:1:1). They were fully characterized by XRD and thermal analyses, NMR and... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - CrystEngComm latest articles - June 21, 2023 Category: Chemistry Authors: Zhi-Qing Wang Source Type: research
A Click Chemistry-Based Artificial Metallo-Nuclease
Angew Chem Int Ed Engl. 2023 Jun 20:e202305759. doi: 10.1002/anie.202305759. Online ahead of print.ABSTRACTArtificial metallonucleases (AMNs) are promising DNA damaging drug candidates. Here, we demonstrate how the 1,2,3-triazole linker produced by the copper-catalysed azide-alkyne cycloaddition (CuAAC) reaction can be directed to build copper-binding AMN scaffolds. We selected biologically inert reaction partners tri-azidomethyl-mesitylene and ethynyl-thiophene to develop TC-Thio, a bioactive C3-symmetric ligand in which three thiophene-triazole moieties are positioned around a central mesitylene core. The ligand was char...
Source: Angewandte Chemie - June 20, 2023 Category: Chemistry Authors: Alex Gibney Raphael E F de Paiva Vandana Singh Robert Fox Damien Thompson Joseph Hennessy Creina Slator Christine McKenzie Pegah Johansson Vickie McKee Fredrik Westerlund Andrew Kellett Source Type: research
Therapeutic Responses to Combination Nivolumab and Temozolomide as Salvage Therapy for Metastatic Melanoma: A Case Series
Oncologist. 2023 Jun 20:oyad184. doi: 10.1093/oncolo/oyad184. Online ahead of print.ABSTRACTThe management of metastatic melanoma patients that fail multiple lines of systemic therapy remains a significant challenge. There is limited literature regarding combination of anti-PD-1 and temozolomide, or of other chemotherapy agents, in melanoma. Here, we present a series of 3 patients with metastatic melanoma and their responses to nivolumab and temozolomide combination therapy after progression on several local/regional therapies, combination immune checkpoint inhibitors, and/or targeted therapies. The novel combinatory strat...
Source: The Oncologist - June 20, 2023 Category: Cancer & Oncology Authors: Rachel S Goodman Seungyeon Jung Jessica Quintos Douglas B Johnson Source Type: research
Bavituximab decreases immunosuppressive myeloid-derived suppressor cells in newly diagnosed glioblastoma patients
DISCUSSION: Bavituximab has activity in newly diagnosed GBM and resulted in on-target depletion of intratumoral immunosuppressive MDSCs. Elevated pre-treatment expression of myeloid-related transcripts in GBM may predict response to bavituximab.PMID:37327319 | DOI:10.1158/1078-0432.CCR-23-0203
Source: Clinical Cancer Research - June 16, 2023 Category: Cancer & Oncology Authors: K Ina Ly Leland G Richardson Mofei Liu Alona Muzikansky Jonathan Cardona Kevin Lou Andrew L Beers Ken Chang James M Brown Xiaoyue Ma David A Reardon Isabel C Arrillaga-Romany Deborah A Forst Justin T Jordan Eudocia Q Lee Jorg Dietrich Lakshmi Nayak Patric Source Type: research
CCL21-CCR7 signaling promotes microglia/macrophage recruitment and chemotherapy resistance in glioblastoma
Cell Mol Life Sci. 2023 Jun 14;80(7):179. doi: 10.1007/s00018-023-04788-7.ABSTRACTGlioblastoma (GBM) is the most common and fatal primary tumor of the central nervous system (CNS) and current treatments have limited success. Chemokine signaling regulates both malignant cells and stromal cells of the tumor microenvironment (TME), constituting a potential therapeutic target against brain cancers. Here, we investigated the C-C chemokine receptor type 7 (CCR7) and the chemokine (C-C-motif) ligand 21 (CCL21) for their expression and function in human GBM and then assessed their therapeutic potential in preclinical mouse GBM mod...
Source: Cellular and Molecular Life Sciences : CMLS - June 14, 2023 Category: Cytology Authors: Luiz Henrique Geraldo Celina Garcia Yunling Xu Felipe Saceanu Leser Izabella Grimaldi Eduardo Sabino de Camargo Magalh ães Joost Dejaegher Lien Solie Cl áudia Maria Pereira Ana Helena Correia Steven De Vleeschouwer Bertrand Tavitian Nathalie Henriques S Source Type: research
HOXD-AS2-STAT3 feedback loop attenuates sensitivity to temozolomide in glioblastoma
CONCLUSION: Our study elucidated the crucial role of the HOXD-AS2-STAT3 positive feedback loop in regulating TMZ sensitivity, suggesting that this could be provided as a potential therapeutic candidate of glioblastoma.PMID:37308741 | DOI:10.1111/cns.14277
Source: CNS Neuroscience and Therapeutics - June 12, 2023 Category: Neuroscience Authors: Zuo-Xin Zhang Peng Ren Yong-Yong Cao Ting-Ting Wang Guo-Hao Huang Yao Li Shuo Zhou Wei Yang Lin Yang Guo-Long Liu Yan Xiang Yu-Chun Pei Qiu-Zi Chen Ju-Xiang Chen Sheng-Qing Lv Source Type: research
