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Total 270 results found since Jan 2013.

Medication use during COVID-19: Review of recent evidence
CONCLUSION: Given the severity of the pandemic and the potential broad effects of implementing safe and effective treatment, this article provides a narrative review of the current evidence behind the most widely used medications to treat COVID-19 in order to enable health care practitioners to make informed decisions in the care of patients with this life-threatening disease.PMID:33727376 | PMC:PMC7963004 | DOI:10.46747/cfp.6703171
Source: Canadian Family Physician Medecin de Famille Canadien - March 17, 2021 Category: Primary Care Authors: T S Brandon Ng Kori Leblanc Darwin F Yeung Teresa S M Tsang Source Type: research

Molecular Mechanism of Action of Repurposed Drugs and Traditional Chinese Medicine Used for the Treatment of Patients Infected With COVID-19: A Systematic Scoping Review
The objective of this systematic scoping review is to provide an overview of the molecular mechanism of action of repurposed drugs or alternative treatment medicines used to attenuate COVID-19 disease.Method: The research articles or gray literature, including theses, government reports, and official news online, were identified from four databases and one search engine. The full content of a total of 160 articles that fulfilled our inclusion criteria was analyzed and information about six drugs (ritonavir, lopinavir, oseltamivir, remdesivir, favipiravir, and chloroquine) and four Traditional Chinese Medicines (Shuang Huan...
Source: Frontiers in Pharmacology - February 12, 2021 Category: Drugs & Pharmacology Source Type: research

Plitidepsin: a repurposed drug for the treatment of COVID-19.
Abstract Finding antivirals to reduce coronavirus disease 2019 (COVID-19) morbidity and mortality has been challenging. Large randomized clinical trials that aimed to test four repurposed drugs, hydroxychloroquine, lopinavir-ritonavir, interferon beta-1a, and remdesivir, have shown that these compounds lacked impact on the COVID-19 course. Although the Phase III COVID-19 vaccine trial results are encouraging, the search for effective COVID-19 therapeutics should not stop. Recently, plitidepsin (aplidin) demonstrated highly effective preclinical activity against severe acute respiratory syndrome coronavirus 2 (SARS...
Source: Antimicrobial Agents and Chemotherapy - February 8, 2021 Category: Microbiology Authors: Martinez MA Tags: Antimicrob Agents Chemother Source Type: research

Fighting COVID-19.
Abstract The current COVID-19 pandemic caused by the novel coronavirus (SARS-CoV2) poses a threat to global health owing to its high rate of spread and severe forms of respiratory infection. The lack of vaccines and antivirals prevents clinical strategies against the disease, creating an emerging need for the development of safe and effective treatments. Strategies for vaccine development include complete vaccines against viruses, subunits, and nucleic acids, but are still in their early stages. Studies carried out to date on possible SARS-CoV2 drug targets highlight glycoprotein S, Mpro (main protease or protease...
Source: Braz J Biol - June 9, 2020 Category: Biology Authors: Campos DMO, Oliveira CBS, Andrade JMA, Oliveira JIN Tags: Braz J Biol Source Type: research

An update on novel COVID-19 pandemic: a battle between humans and virus.
Authors: Prajapati S, Sharma M, Kumar A, Gupta P, Narasimha Kumar GV Abstract In the 21st century, human civilization has witnessed three major epidemics caused by Coronaviruses namely severe acute respiratory syndrome coronavirus (SARS CoV) in 2003, Middle East respiratory syndrome coronavirus (MERS CoV) in 2012 and 2019 novel coronavirus (2019 nCoV) or coronavirus disease (COVID 19) in 2019. Among these, COVID-19 has greater transmission and mortality rate. 2019 nCoV belongs to a large family of positive sense single-stranded RNA viruses (+ssRNA) that can be isolated in different animal species. The most communal...
Source: European Review for Medical and Pharmacological Sciences - June 5, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

A review of candidate therapies for Middle East respiratory syndrome from a molecular perspective.
Abstract There have been 2040 laboratory-confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) in 27 countries, with a mortality rate of 34.9 %. There is no specific therapy. The current therapies have mainly been adapted from severe acute respiratory syndrome (SARS-CoV) treatments, including broad-spectrum antibiotics, corticosteroids, interferons, ribavirin, lopinavir-ritonavir or mycophenolate mofetil, and have not been subject to well-organized clinical trials. The development of specific therapies and vaccines is therefore urgently required. We examine existing and potential therapies a...
Source: Journal of Medical Microbiology - August 31, 2017 Category: Microbiology Authors: Rabaan AA, Alahmed SH, Bazzi AM, Alhani HM Tags: J Med Microbiol Source Type: research