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The Efficacy and Tolerability of Selective Serotonin Reuptake Inhibitors for Motor Recovery in Non-depressed Patients After Acute Stroke: A Meta-Analysis
Conclusions: Fluoxetine and citalopram can promote motor recovery in non-depressed patients with acute stroke, but it is necessary to pay attention to the possible AEs of fluoxetine, such as hyponatremia, seizure and fracture.Systematic Review Registration: PROSPERO, identifier [CRD42021227452].
Source: Frontiers in Neurology - October 20, 2021 Category: Neurology Source Type: research

Escitalopram improves neural functional prognosis and endothelial dysfunction in patients with acute cerebral infarction.
CONCLUSIONS: Treatment with escitalopram early after ischemic stroke can improve neural functional prognoses and endothelial dysfunction. Escitalopram had less side effects, which is worthy of clinical prophylactic application. PMID: 33185618 [PubMed - in process]
Source: Restorative Neurology and Neuroscience - November 17, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Treatment of Post-Stroke Depression
We present the reader with the most recent evidence to support pharmacological, psychosocial, and neuromodulation interventions in PSD. We also discuss the relevance of using antidepressants and psychotherapy to prevent PSD and discuss evidence that antidepressant treatment may reduce mortality after stroke.Recent findingsNeuroinflammation and decrease neurogenesis and plasticity may play an important role in the mechanism of PSD. The strongest predictors of PSD are stroke severity, early physical disability, and severity of loss of functioning. Nevertheless, populations at risk for PSD are yet to be identified. Recent met...
Source: Current Treatment Options in Neurology - June 24, 2019 Category: Neurology Source Type: research

Is bupropion useful in the treatment of post-stroke thalamic apathy? A case report and considerations.
Authors: Aragona B, De Luca R, Piccolo A, Le Cause M, Destro M, Casella C, Filoni S, Calabrò RS Abstract Post-stroke apathy is considered to be one of the clinical consequences of lesions affecting the structures of the prefrontal cortex, basal ganglia, thalamus and limbic system. However, there is no current consensus on the treatment of post-stroke apathy, which mainly depends on the underlying etiology and comorbidities. A 62-year-old man, affected by hemorrhagic stroke in the left thalamus, presented with mood depression, anhedonia, hyporexia and marked apathy. The patient underwent clinical evaluation before ...
Source: Functional Neurology - January 23, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Current Treatment Options: Headache Related to Menopause —Diagnosis and Management
AbstractPurpose of reviewMenopause is a life-changing event in numerous ways. Many women with migraine hold hope that the transition to the climacteric state will coincide with a cessation or improvement of migraine. This assumption is based mainly on common lay perceptions as well as assertions from many in the healthcare community. Unfortunately, evidence suggests this is far from the rule. Many women turn to a general practitioner or a headache specialist for prognosis and management. A natural instinct is to manipulate the offending agent, but in some cases, this approach backfires, or the concern for adverse events ou...
Source: Current Treatment Options in Neurology - March 6, 2018 Category: Neurology Source Type: research

Risk of Stroke Among Older Medicare Antidepressant Users With Traumatic Brain Injury
Conclusion: Findings from this study will aid prescribers in choosing appropriate antidepressants to treat depression in older adults with TBI.
Source: The Journal of Head Trauma Rehabilitation - January 1, 2017 Category: Neurology Tags: Focus on Clinical Research and Practice Source Type: research