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Specialty: Cytology
Drug: Acetylcysteine
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Total 134 results found since Jan 2013.
Reactive Oxygen Species-Mediated Mitophagy and Cell Apoptosis are Involved in the Toxicity of Aluminum Chloride Exposure in GC-2spd
This study aimed to examine the impact of AlCl3 exposure on mitophagy and mitochondrial apoptosis in testicular tissue and mouse spermatocytes. Reactive oxygen species (ROS) and ATP levels were measured in GC-2spd after AlCl3 exposure using a multifunctional enzyme labeler. The changes in mitochondrial membrane potential (MMP) and TUNEL were observed through confocal laser microscopy, and the expression of proteins associated with mitophagy and apoptosis was analyzed using Western blot. Our results demonstrated that AlCl3 exposure disrupted mitophagy and increased apoptosis-related protein expression in testicular tissues....
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Hui- Xin Peng Fu Chai Ke-Heng Chen Yan-Xin Huang Guang-Ji Wei Huixiong Yuan Yan-Fang Pang Shi-Hua Luo Chun-Fang Wang Wen-Cheng Chen Source Type: research
N-Acetylcysteine may exert hepatoprotective effect by regulating Meteorin-Like levels in Adriamycin-induced liver injury
This study aimed to evaluate whether N-acetylcysteine (NAC) has hepatoprotective effects against ADR-induced hepatotoxicity in rats. In addition, it was aimed to determine how Meteorin-Like (MtrnL), which has pleiotropic effects on immunology, inflammation, and metabolism, is affected by ADR and/or NAC applications in liver tissue. 28 rats were randomly assigned to one of four equal groups in the study: control (no treatment), NAC (150 mg/kg/day of NAC intraperitoneally (i.p), ADR (15 mg/kg only on the first day of the experiment), and ADR + NAC (ADR 15 mg/kg on the first day of the experiment + 150 mg/kg/day NAC i.p). Aft...
Source: Cell Stress and Chaperones - September 5, 2023 Category: Cytology Authors: Sercan Kaya Tuba Yalc ın Ahmet Tektemur Tuncay Kulo ğlu Source Type: research
Cytotoxic and Apoptotic Effects of Pinostilbene and Bortezomib Combination Treatment on Human Multiple Myeloma Cells
Int J Mol Sci. 2023 Aug 9;24(16):12590. doi: 10.3390/ijms241612590.ABSTRACTMultiple myeloma (MM) is a cancer of plasma cells in the bone marrow characterized by bone lesions, hypercalcemia, anemia, and renal failure. Bortezomib (BTZ), a common treatment for MM, is a proteasome inhibitor that induces apoptosis in MM cells. However, high doses of BTZ can be very toxic, signifying a need for a synergistic drug combination to improve treatment efficacy. Resveratrol (RES), a phenolic compound found in grapes, has been shown to inhibit MM cell growth. We sought to identify a synergistic combination of BTZ with a RES derivative a...
Source: Cell Research - August 26, 2023 Category: Cytology Authors: Anna Staskiewicz Erica Wong Michael Tucker Riya Farhin Jonathan Park Rana Saade Tina Alkhazali Tu Dang Xinyu Wang Source Type: research
ROS-Sp1 axis is involved in thermochemotherapy-enhanced sensitivity of pancreatic cancer cells to gemcitabine
In conclusion, thermochemotherapy inhibited pancreatic cell viability, migration and invasion, and promoted cell apoptosis by inducing excessive ROS production, which subsequently suppressed Sp1 expression and the downstream Cox-2.PMID:37545170 | DOI:10.1002/cbin.12073
Source: Cell Biology International - August 7, 2023 Category: Cytology Authors: Pan Xi Xiaojuan Ma Fuquan Hu Liang Li Huijuan Liu Jing Zhou Wenan Wu Source Type: research
Alleviation of acetaminophen-induced liver failure using silibinin nanoliposomes: An in vivo study
CONCLUSION: The results of this study support the significant hepatoprotective effect of SLB nanoliposomes against acetaminophen-induced toxicity depending on the route of administration.PMID:37506470 | DOI:10.1016/j.bbrc.2023.07.045
Source: Cell Research - July 28, 2023 Category: Cytology Authors: Fatemeh Gheybi Alireza Khooei Azam Hoseinian Maham Doagooyan Kebria Houshangi Mahmoud Reza Jaafari Arash Papi Zahra Khoddamipour Amirhossein Sahebkar Seyedeh Hoda Alavizadeh Source Type: research
Deciphering the mitophagy receptor network identifies a crucial role for OPTN (optineurin) in acute myeloid leukemia
Autophagy. 2023 Jul 13:1-15. doi: 10.1080/15548627.2023.2230839. Online ahead of print.ABSTRACTThe selective autophagic degradation of mitochondria via mitophagy is essential for preserving mitochondrial homeostasis and, thereby, disease maintenance and progression in acute myeloid leukemia (AML). Mitophagy is orchestrated by a variety of mitophagy receptors whose interplay is not well understood. Here, we established a pairwise multiplexed CRISPR screen targeting mitophagy receptors to elucidate redundancies and gain a deeper understanding of the functional interactome governing mitophagy in AML. We identified OPTN (optin...
Source: Autophagy - July 13, 2023 Category: Cytology Authors: Laura M Meyer Sebastian E Koschade Jonas B Vischedyk Marlyn Thoelken Andrea Gubas Martin Wegner Marion Basoglu Stefan Knapp Manuel Kaulich Stefan Eimer Shabnam Shaid Christian H Brandts Source Type: research
Evidence for the Metabolic Activation of Deferasirox < em > In Vitro < /em > and < em > In Vivo < /em >
Chem Res Toxicol. 2023 Jul 12. doi: 10.1021/acs.chemrestox.2c00416. Online ahead of print.ABSTRACTDeferasirox (DFS) is used for the treatment of iron accumulation caused by the need for long-term blood transfusions, such as thalassemia or other rare anemia. Liver injury due to exposure to DFS has been documented, and the toxic mechanisms of DFS are unknown. The present study aimed to investigate the reactive metabolites of DFS in vitro and in vivo to help us understand the mechanisms of DFS hepatotoxicity. Two hydroxylated metabolites (5-OH and 5'-OH) were identified during incubation of DFS-supplemented rat liver microsom...
Source: Cell Research - July 12, 2023 Category: Cytology Authors: Mengdie Su Yanjia Zhao Mei Li Chenyang Jia He Liu Yue Zhang Weiwei Li Ying Peng Jiang Zheng Source Type: research
Reactive oxygen species-mediated endoplasmic reticulum stress contributes to osteocyte death induced by orthodontic compressive force
This study first proposes the ERS pathway as a new potential pathway for regulating the rate of OTM based on osteocyte death. RESEARCH HIGHLIGHTS: The orthodontic force increases osteocyte death in rat alveolar bone. The compressive force causes osteocyte apoptosis by the endoplasmic reticulum stress (ERS) pathway in vitro. The ROS scavenger NAC blocked compressive force-induced ERS and osteocyte apoptosis.PMID:37382312 | DOI:10.1002/jemt.24382
Source: Cell Research - June 29, 2023 Category: Cytology Authors: Ming Yan Yun Zhang Wanting Niu Kezhou Liu Lingyun Xue Kexin Zhou Source Type: research
NAT10 regulates the LPS-induced inflammatory response via the NOX2-ROS-NF- κB pathway in macrophages
In this study, the expression of NAT10 in macrophages was found to decrease during LPS-induced inflammation. NAT10 knockdown significantly reduced the generation of inflammatory factors, while NAT10 overexpression had the opposite effect. RNA sequencing revealed that the differentially expressed genes were enriched in the NF-κB signalling pathway and oxidative stress. Both the NF-κB inhibitor Bay11-7082 and the ROS scavenger N-acetyl-L-cysteine (NAC) could reverse the upregulation of inflammatory factors. NAC inhibited the phosphorylation of NF-κB, but Bay11-7082 had no effect on the production of ROS in NAT10-overexpre...
Source: Cell Research - June 12, 2023 Category: Cytology Authors: Zhanqi Zhang Yiwen Zhang Yongjie Cai Di Li Jinlin He Zhihui Feng Qiong Xu Source Type: research
Anti-Warburg effect via generation of ROS and inhibition of PKM2/ β-catenin mediates apoptosis of lambertianic acid in prostate cancer cells
Phytother Res. 2023 May 26. doi: 10.1002/ptr.7903. Online ahead of print.ABSTRACTTo elucidate the underlying antitumor mechanism of lambertianic acid (LA) derived from Pinus koraiensis, the role of cancer metabolism related molecules was investigated in the apoptotic effect of LA in DU145 and PC3 prostate cancer cells. MTT assay for cytotoxicity, RNA interference, cell cycle analysis for sub G1 population, nuclear and cytoplasmic extraction, lactate, Glucose and ATP assay by ELISA, Measurement of reactive oxygen species (ROS) generation, Western blotting, and immunoprecipitation assay were conducted in DU145 and PC3 prosta...
Source: Cell Research - May 26, 2023 Category: Cytology Authors: Ji-Na Pak Hyo-Jung Lee Deok Yong Sim Ji Eon Park Chi-Hoon Ahn Su-Yeon Park Jae-Ho Khil Bumsang Shim Bonglee Kim Sung-Hoon Kim Source Type: research
NQO1 alleviates renal fibrosis by inhibiting the TLR4/NF- κB and TGF-β/Smad signaling pathways in diabetic nephropathy
CONCLUSIONS: These data suggest that NQO1 alleviates diabetes-induced renal inflammation and fibrosis by regulating the TLR4/NF-κB and TGF-β/Smad signaling pathways.PMID:37196773 | DOI:10.1016/j.cellsig.2023.110712
Source: Cellular Signalling - May 17, 2023 Category: Cytology Authors: Duojun Qiu Shan Song Ning Chen Yawei Bian Chen Yuan Wei Zhang Huijun Duan Yonghong Shi Source Type: research
