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Fight Aging! Newsletter, May 23rd 2022
In conclusion, remofuscin activates the lysosome-to-nucleus pathway in C. elegans, thereby increasing the expression levels of xenobiotic detoxification genes resulted in extending their lifespan. Naked Mole-Rat Skin Shows Fewer Signs of Aging https://www.fightaging.org/archives/2022/05/naked-mole-rat-skin-shows-fewer-signs-of-aging/ Naked mole-rats exhibit a maximum life span that is many times longer than is the case for similarly sized mammals. Further, they are negligibly senescent, showing few age-related declines in function across much of that lengthy life span. That includes maintenance of stem c...
Source: Fight Aging! - May 22, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Link between gut microbiota dysbiosis and chronic kidney disease
Eur Rev Med Pharmacol Sci. 2022 Mar;26(6):2057-2074. doi: 10.26355/eurrev_202203_28354.ABSTRACTDuring chronic kidney disease (CKD), typical alterations in the gut microbiota are observed. The kidney no longer plays the role of the main excretory organ as this function is performed by the intestine. In CKD patients, an alteration of intestinal permeability and a degradation of the protective mucous layer are observed. These changes in the intestinal barrier allow the passage of bacterial material from the intestine to the bloodstream through the intestinal wall. This phenomenon contributes to the induction of the chronic in...
Source: Pharmacological Reviews - April 1, 2022 Category: Drugs & Pharmacology Authors: A Noce M Marchetti G Marrone L Di Renzo M Di Lauro F Di Daniele M Albanese N Di Daniele A De Lorenzo Source Type: research

Application of Porcine Kidney-Derived Extracellular Matrix as Coating, Hydrogel, and Scaffold Material for Renal Proximal Tubular Epithelial Cell
CONCLUSIONS: We concluded that renal ECM can be a suitable material for RPTE cell culture and usage. More practically, the coated renal ECM stimulates RPTE cell proliferation, and the hydrogel and scaffold of renal ECM provide useful 3D culture niche and cell delivery vehicles maintaining renal cell properties.PMID:35127940 | PMC:PMC8816548 | DOI:10.1155/2022/2220641
Source: Cell Research - February 7, 2022 Category: Cytology Authors: Eun Hye Lee So Young Chun Bo Hyun Yoon Hyun Tae Kim Jae-Wook Chung Jun Nyung Lee Yun-Sok Ha Tae Gyun Kwon Kyeong-Hyeon Byeon Bum Soo Kim Source Type: research

Diagnostic accuracy of serum cystatin C in chronic kidney disease: a meta-analysis.
CONCLUSION: SCysC appears to be a good biomarker in the definition of CKD. However, its performance is different in subgroups restricted by clinical settings, race, and sCysC assay. PMID: 26200185 [PubMed - as supplied by publisher]
Source: Clinical Nephrology - July 24, 2015 Category: Urology & Nephrology Authors: Wei L, Ye X, Pei X, Wu J, Zhao W Tags: Clin Nephrol Source Type: research