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Fight Aging! Newsletter, August 8th 2022
In conclusion, aging research will benefit from a better definition of how specific regulators map onto age-dependent change, considered on a phenotype-by-phenotype basis. Resolving some of these key questions will shed more light on how tractable (or intractable) the biology of aging is. Does Acarbose Extend Life in Short Lived Species via Gut Microbiome Changes? https://www.fightaging.org/archives/2022/08/does-acarbose-extend-life-in-short-lived-species-via-gut-microbiome-changes/ Acarbose is one of a few diabetes medications shown to modestly slow aging in short-lived species. Researchers here take a ...
Source: Fight Aging! - August 7, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Erratum: Vol. 71, No. 22: Pediatric Melatonin Ingestions - United States, 2012-2021
MMWR Morb Mortal Wkly Rep. 2022 Jul 8;71(27):885. doi: 10.15585/mmwr.mm7127a4.NO ABSTRACTPMID:35797208 | DOI:10.15585/mmwr.mm7127a4
Source: MMWR Morb Mortal Wkl... - July 7, 2022 Category: Epidemiology Source Type: research

Pediatric Melatonin Ingestions - United States, 2012-2021
This study assessed isolated melatonin ingestions among the pediatric population (defined here as children, adolescents, and young adults aged ≤19 years) during January 1, 2012-December 31, 2021, using the American Association of Poison Control Centers' National Poison Data System (NPDS). During the 10-year study period, 260,435 pediatric melatonin ingestions were reported to NPDS, and the annual number of ingestions increased 530%. In addition, pediatric melatonin ingestions accounted for 4.9% of all pediatric ingestions reported to poison control centers in 2021 compared with 0.6% in 2012. Pediatric hospitalizations an...
Source: MMWR Morb Mortal Wkl... - June 2, 2022 Category: Epidemiology Authors: Karima Lelak Varun Vohra Mark I Neuman Michael S Toce Usha Sethuraman Source Type: research

The interplay of pineal hormones and socioeconomic status leading to colorectal cancer disparity
Transl Oncol. 2022 Feb;16:101330. doi: 10.1016/j.tranon.2021.101330. Epub 2022 Jan 3.ABSTRACTColorectal cancer (CRC) is the third leading cause of cancer-related deaths in the United States. Despite increased screening options and state-of-art treatments offered in clinics, racial differences remain in CRC. African Americans (AAs) are disproportionately affected by the disease; the incidence and mortality are higher in AAs than Caucasian Americans (CAs). At the time of diagnosis, AAs more often present with advanced stages and aggressive CRCs, primarily accounting for the racial differences in therapeutic outcomes and mort...
Source: Translational Oncology - January 6, 2022 Category: Cancer & Oncology Authors: Talaijha Haynes Gabriela Oprea-Ilies Upender Manne Rajesh Singh Shailesh Singh Hina Mir Source Type: research

Melatonin: a pleiotropic hormone as a novel potent therapeutic candidate in arsenic toxicity
CONCLUSION: Due to its highly lipophilic and small size properties, melatonin accesses all intracellular organs by easily passing via the cell membrane and prevents protein, DNA damage, and lipid peroxidation. In particular, melatonin, by protecting and reducing oxidative stress in mitochondria, can normalize homeostasis and mitochondrial function and ultimately prevent apoptosis and cell death.PMID:34453671 | DOI:10.1007/s11033-021-06669-3
Source: Molecular Biology Reports - August 28, 2021 Category: Molecular Biology Authors: Naseh Abdollahzade Maryam Majidinia Shirin Babri Source Type: research

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