• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Clinical outcomes of secondary prevention strategies for young patients with cryptogenic stroke and patent foramen ovale.
Conclusions The diagnosis of stroke in patients with PFO could be confirmed in 50% of cases only, underlining the importance of a multidisciplinary evaluation of these patients. A very low ischaemic recurrence rate was observed in the medical therapy group, suggesting that a personalized treatment based on a prespecified diagnostic algorithm yields good clinical results irrespective of the treatment modality. Given the low number of recurrences, larger cohorts may be needed to prove significant differences. PMID: 28705105 [PubMed - as supplied by publisher]
Source: Acta Cardiologica - July 15, 2017 Category: Cardiology Tags: Acta Cardiol Source Type: research

The dispersion of myocardial repolarization in ischemic stroke and intracranial hemorrhage
Markers of dispersion of myocardial repolarization have been proposed to identify the patients at higher risk of malignant arrhythmic events. The aim of the present study is to assess a possible association of the electrocardiografic (ECG) markers of the dispersion of repolarization with the type of stroke, involvement of insula, neurological severity (National Institutes of Health Stroke Scale, NIHSS score), and disability (modified Rankin Scale, mRS score) in patients with a cerebrovascular event.
Source: Journal of Electrocardiology - May 17, 2018 Category: Cardiology Authors: Alessandra Danese, Manuel Cappellari, Elia Pancheri, Giacomo Mugnai, Nicola Micheletti, Giampaolo Tomelleri, Monica Carletti, Giulia Turri, Vincenzo Marafioti, Salvatore Monaco, Bruno Bonetti, Paolo Bovi Source Type: research

Prolonged QTc interval and Insula in patients with ischemic stroke: Inductive or abductive reasoning?
While a great emphasis has been placed on pathophysiological mechanisms underlying the long QT syndromes (LQTS), both congenital and acquired forms, little attention has been focused on the mechanisms whereby a brain damage could induce changes in the QTc interval. Until now, there has been no precise explanation for the frequently observed relationship between acute cerebrovascular events and QTc interval prolongation. Many excellent studies with inductive reasoning proposed QTc effects of insular cortex stimulation [1,2] Few and controversial studies with abductive reasoning investigated an association between prolonged ...
Source: International Journal of Cardiology - August 4, 2014 Category: Cardiology Authors: Vincenzo Marafioti, Giulia Turri, Andrea Rossi, Vincenzo Carbone, Salvatore Monaco, Corrado Vassanelli Source Type: research

Prolonged QTc interval and insula in patients with ischemic stroke: Inductive or abductive reasoning?
While a great emphasis has been placed on pathophysiological mechanisms underlying the long QT syndromes (LQTS), both congenital and acquired forms, little attention has been focused on the mechanisms whereby a brain damage could induce changes in the QTc interval. Until now, there has been no precise explanation for the frequently observed relationship between acute cerebrovascular events and QTc interval prolongation. Many excellent studies with inductive reasoning proposed QTc effects of insular cortex stimulation [1,2] Few and controversial studies with abductive reasoning investigated an association between prolonged ...
Source: International Journal of Cardiology - August 4, 2014 Category: Cardiology Authors: Vincenzo Marafioti, Giulia Turri, Andrea Rossi, Salvatore Monaco, Vincenzo Carbone Tags: Letter to the Editor Source Type: research

Previous use of Statins and Atrial Electrical Remodeling in Patients with Cryptogenic Stroke
Source: Cardiovascular and Haematological Disorders - Drug Targets - February 20, 2018 Category: Cardiology Authors: Acampa, Maurizio Lazzerini, Pietro E. Guideri, Francesca Tassi, Rossana Lo Monaco, Andrea Martini, Giuseppe Tags: Research article Source Type: research

Inflammation and Atrial Electrical Remodeling in Patients With Embolic Strokes of Undetermined Source
About one third of ischaemic strokes are classified as embolic strokes of undetermined source (ESUS). A silent atrial fibrillation (AF) may play a pathogenic role in these strokes and P wave dispersion (PWD), representing an electrocardiograph (ECG) predictor for paroxysmal AF, thereby a potential marker of covert cardioembolism, was found to be increased in cryptogenic stroke. Furthermore, current evidence links AF to inflammation: inflammatory markers, such as high-sensitive C-reactive protein (hsCRP), have been related to the development and persistence of AF, possibly by promoting atrial remodelling.
Source: Heart, Lung and Circulation - May 8, 2018 Category: Cardiology Authors: Maurizio Acampa, Pietro Enea Lazzerini, Francesca Guideri, Rossana Tassi, Andrea Lo Monaco, Giuseppe Martini Tags: Original Article Source Type: research

Inflammation and Atrial Electrical Remodelling in Patients With Embolic Strokes of Undetermined Source
About one third of ischaemic strokes are classified as embolic strokes of undetermined source (ESUS). A silent atrial fibrillation (AF) may play a pathogenic role in these strokes and P wave dispersion (PWD), representing an electrocardiographic (ECG) predictor for paroxysmal AF, thereby a potential marker of covert cardioembolism, was found to be increased in cryptogenic stroke. Furthermore, current evidence links AF to inflammation: inflammatory markers, such as high-sensitive C-reactive protein (hsCRP), have been related to the development and persistence of AF, possibly by promoting atrial remodelling.
Source: Heart, Lung and Circulation - May 7, 2018 Category: Cardiology Authors: Maurizio Acampa, Pietro Enea Lazzerini, Francesca Guideri, Rossana Tassi, Andrea Lo Monaco, Giuseppe Martini Tags: Original Article Source Type: research

3PO inhibits glycolysis but does not bind to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3)
Background and Aims: Intra-plaque angiogenesis (IP), present in advanced human atherosclerotic plaques, promotes unstable vascular disease and contributes to increased risk of myocardial infarction and stroke. Because proliferating endothelial cells (ECs) rely on glycolysis for up to 85% of their energy demand, glycolysis inhibition may represent a novel strategy to prevent IP neovascularization, thereby promoting plaque stabilization. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 (PFKFB3) is a key enzyme of the glycolysis pathway and plays an essential role in angiogenesis.
Source: Atherosclerosis - December 1, 2020 Category: Cardiology Authors: B. Emini Veseli, P. Perrotta, A. Abdali, P. Van Wielendaele, G. Monaco, A.-M. Lambeir, M.L. Gelmi, G. Bultynck, W. Martinet, G. De Meyer Source Type: research

Direct oral anticoagulants and therapeutic adherence: do not let your guard down
CONCLUSIONS: Polypharmacy, patient's isolation, such as a low education level were statistically associated with a low therapeutic adherence. Therapeutic adherence remains an unsolved problem for anticoagulated patient. To identify patients at higher risk of poor compliance and therapeutic failure and establish targeted care pathways is a priority.PMID:33896375 | DOI:10.1080/00015385.2021.1908702
Source: Acta Cardiologica - April 26, 2021 Category: Cardiology Authors: Leonardo Di Gennaro Martina Monaco Claudia Riccio Erica De Candia Maria Adele Alberelli Cinzia di Martino Maria Basso Maria Antonietta Ferretti Stefano Lancellotti Raimondo De Cristofaro Source Type: research