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Attitudes toward COVID-19 vaccination during the state of emergency in Osaka, Japan
CONCLUSIONS: Most respondents expressed favorable attitudes toward COVID-19 vaccination while hesitancy was disproportionately high in certain populations. Efforts are needed to ensure accessible vaccine information resources and healthcare services.PMID:36584068 | PMC:PMC9803118 | DOI:10.1371/journal.pone.0279481
Source: Cancer Control - December 30, 2022 Category: Cancer & Oncology Authors: Satomi Odani Shihoko Koyama Yuichi Katsumi Isao Miyashiro Source Type: research

Results of Novel Clinical Study of Guselkumab and Golimumab Combination Therapy Show Adults with Moderately to Severely Active Ulcerative Colitis Maintained Higher Rates of Clinical, Histologic, and Endoscopic Remission at Week 38
SPRING HOUSE, PENNSYLVANIA, October 10, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from an ongoing analysis of a Phase 2a clinical trial showing adults with moderately to severely active ulcerative colitis (UC) who received 12 weeks of combination induction therapy with guselkumab and golimumab, followed by a transition to guselkumab alone for maintenance, achieved a clinical remission ratea (based on the modified Mayo score [mMayo])b at week 38 of 47.9 percent, a higher rate than induction and maintenance treatment with either guselkumab alone (31.0 percent) or golimumab al...
Source: Johnson and Johnson - October 10, 2022 Category: Pharmaceuticals Source Type: news

Establishment of Mono-scaled Benefit/Risk Analysis of HPV Vaccine
In this study, we developed a new method to calculate the benefits and risks of the HPV vaccines using disability-adjusted life year (DALY) as the mono-scaled weight for various benefits and risks relevant to the vaccines. We evaluated benefits as a gain of DALY values for cervical cancer and risks as the loss of DALY values for various adverse events by the vaccination. To calculate the loss of DALY values, we integrated all adverse events in the International Classification of Diseases chapters. The novel method reflected the men-women ratio of this epidemiological disease to a certain extent. Among the vaccinated women,...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 26, 2022 Category: Drugs & Pharmacology Authors: Katsura Tsukamoto Manami Inoue Hirohito Mori Naoki Matsumaru Source Type: research

Effect of the Tokyo 2020 Summer Olympic Games on COVID-19 incidence in Japan: a synthetic control approach
CONCLUSIONS: Given the increasing likelihood that new emerging infectious diseases will be reported in the future, we believe that the results of this study should serve as a sentinel warning for upcoming mega-events during COVID-19 and future pandemics.PMID:36127076 | DOI:10.1136/bmjopen-2022-061444
Source: Cancer Control - September 20, 2022 Category: Cancer & Oncology Authors: Daisuke Yoneoka Akifumi Eguchi Kentato Fukumoto Takayuki Kawashima Yuta Tanoue Takahiro Tabuchi Hiroaki Miyata Cyrus Ghaznavi Kenji Shibuya Shuhei Nomura Source Type: research

Genotype prevalence and age distribution of human papillomavirus from infection to cervical cancer in Japanese women: A systematic review and meta-analysis
This study was registered with PROSPERO: CRD42018117596.RESULTS: A total of 57759 women with normal cytology, 1766 ASCUS, 3764 LSIL, 2017 HSIL, 3130 CIN1, 1219 CIN2, 869 CIN3/AIS, and 4306 ICC (which included 1032 ICC-SCC, and 638 ICC-ADC) were tested for HPV. The summary estimate of any-HPV genotype in women with normal cytology was 15·6% (95% CI: 12·3-19·4) and in invasive cervical cancer (ICC) was 85·6% (80·7-89·8). The prevalence of HR-HPV was 86·0% (95% CI: 73·9-94·9) for cytological cases of HSIL, 76·9% (52·1-94·7) for histological cases of CIN3/AIS, and 75·7% (68·0-82·6) for ICC. In women with ICC, th...
Source: Cancer Control - September 9, 2022 Category: Cancer & Oncology Authors: Matthew Palmer Kota Katanoda Eiko Saito Cecilia Acuti Martellucci Shiori Tanaka Sayaka Ikeda Haruka Sakamoto Dorothy Machelek Julia Ml Brotherton Jane S Hocking Source Type: research

The 'best friend effect': a promising tool to encourage HPV vaccination in Japan
CONCLUSION: If mothers who have had their daughters vaccinated were to recommend HPV vaccination to their close friends, 'the best friend effect' should promote others to be vaccinated.PMID:36057048 | DOI:10.1007/s10147-022-02240-7
Source: Cancer Control - September 3, 2022 Category: Cancer & Oncology Authors: Asami Yagi Yutaka Ueda Yoshimi Tomine Sayaka Ikeda Mamoru Kakuda Satoshi Nakagawa Kosuke Hiramatsu Ai Miyoshi Eiji Kobayashi Toshihiro Kimura Kei Hirai Tadashi Kimura Source Type: research

Fight Aging! Newsletter, August 1st 2022
In this study, we used the recently released Infinium Mouse Methylation BeadChip to compare such epigenetic modifications in C57BL/6 (B6) and DBA/2J (DBA) mice. We observed marked differences in age-associated DNA methylation in these commonly used inbred mouse strains, indicating that epigenetic clocks for one strain cannot be simply applied to other strains without further verification. Interestingly, the CpGs with highest age-correlation were still overlapping in B6 and DBA mice and included the genes Hsf4, Prima1, Aspa, and Wnt3a. Furthermore, Hsf4, Aspa, and Wnt3a revealed highly significant age-associated DNA methyla...
Source: Fight Aging! - July 31, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Change of HPV vaccination rates in Japan: the effect of individual notifications implemented by local governments
CONCLUSION: This study clearly demonstrates the importance of providing information for routine vaccination directly to the targets and their parents.PMID:35879494 | DOI:10.1007/s10147-022-02213-w
Source: Cancer Control - July 25, 2022 Category: Cancer & Oncology Authors: Asami Yagi Yutaka Ueda Satoshi Nakagawa Sayaka Ikeda Mamoru Kakuda Kosuke Hiramatsu Ai Miyoshi Eiji Kobayashi Toshihiro Kimura Kei Hirai Tomio Nakayama Etsuko Miyagi Masayuki Sekine Takayuki Enomoto Tadashi Kimura Source Type: research

Importance of human papillomavirus vaccination leaflets focusing on the safety profile targeted pediatricians in Japan
CONCLUSION: Leaflets emphasizing an explanation of adverse events may contribute to mothers' decision making for HPV vaccination.PMID:35842338 | DOI:10.1016/j.vaccine.2022.07.008
Source: Vaccine - July 16, 2022 Category: Allergy & Immunology Authors: Yousuke Imanishi Takahiro Kinoshita Masahiko Sakamoto Megumi Ichimiya Makiko Mitsunami Takayuki Takahashi Daisuke Shigemi Mihyon Song Kanako Inaba Source Type: research

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