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Clinimetric properties of the Fugl-Meyer assessment with adapted guidelines for the assessment of arm function in hemiparetic patients after stroke.
Conclusions The Japanese version of the FMA motor domain and all domains can reliably assess the affected upper extremities in patients with mild-to-severe hemiparesis after stroke for both non-simultaneous and simultaneous assessment. PMID: 30028660 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - July 20, 2018 Category: Neurology Authors: Amano S, Umeji A, Uchita A, Hashimoto Y, Takebayashi T, Takahashi K, Uchiyama Y, Domen K Tags: Top Stroke Rehabil Source Type: research

A Case of Posterior Circulation Ischemic Stroke Caused by Heparin-Induced Thrombocytopenia after Detaining Hepatic Arterial Infusion Catheter
In Japan, hepatic arterial infusion chemotherapy (HAIC) using reservoir system is recommended for patients with hepatocellular carcinoma (HCC) whose hepatic spare ability is favorable. Arterial infusion catheter is commonly detained in hepatic artery via femoral or brachial artery. In our hospital, catheter is often inserted by puncturing the left subclavian or brachial artery considering the patient's activities of daily living (ADL) during long-term detaining. However, it rarely causes posterior circulation ischemic stroke because of the left vertebral artery branches on the path of catheter.
Source: Journal of Stroke and Cerebrovascular Diseases - May 30, 2018 Category: Neurology Authors: Koji Hirashita, Atsushi Matsumoto, Satoru Yabuno, Takahiro Kanda, Masatoshi Yunoki, Kimihiro Yoshino Tags: Case Studies Source Type: research

Evaluation of Intraplaque Neovascularization Using Superb Microvascular Imaging and Contrast-Enhanced Ultrasonography
Several studies have shown a linkage between intraplaque neovascularization (IPN) and plaque instability. Although contrast-enhanced ultrasonography (CEUS) may help visualize IPN in the carotid artery, its benefits are limited in Japan, where there is no health insurance coverage for contrast agents in medical imaging. Superb microvascular imaging (SMI), however, enables the depiction of low-velocity blood flow. The current study compares the diagnostic accuracy of SMI and CEUS in the evaluation of IPN.
Source: Journal of Stroke and Cerebrovascular Diseases - May 10, 2018 Category: Neurology Authors: Kazumasa Oura, Tadayoshi Kato, Hideki Ohba, Yasuo Terayama Source Type: research

Accelerating Cell Therapy for Stroke in Japan Special Reports
Source: Stroke - March 26, 2018 Category: Neurology Authors: Kiyohiro Houkin, Hideo Shichinohe, Koji Abe, Teruyo Arato, Mari Dezawa, Osamu Honmou, Nobutaka Horie, Yasuo Katayama, Kohsuke Kudo, Satoshi Kuroda, Tomohiro Matsuyama, Ichiro Miyai, Izumi Nagata, Kuniyasu Niizuma, Ken Sakushima, Masanori Sasaki, Norihiro Tags: Cell Therapy, Clinical Studies, Stem Cells, Translational Studies, Ischemic Stroke Special Report Source Type: research

Risk Factors for and Clinical Consequences of Multiple Intracranial Aneurysms Clinical Sciences
Conclusions—Female sex, higher age, arterial hypertension, smoking, and familial IA are major risk factors for MIA. In addition, MIA patients are at risk for enhanced IA formation. Further studies are needed to evaluate rupture risk and the role of ethnicity, especially in the context of increased MIA identification with improved neurovascular imaging.
Source: Stroke - March 26, 2018 Category: Neurology Authors: Ramazan Jabbarli, Thiemo Florin Dinger, Marvin Darkwah Oppong, Daniela Pierscianek, Philipp Dammann, Karsten H. Wrede, Klaus Kaier, Martin Kohrmann, Michael Forsting, Christoph Kleinschnitz, Ulrich Sure Tags: Risk Factors, Cerebral Aneurysm, Cerebrovascular Disease/Stroke, Aneurysm Original Contributions Source Type: research

Desirable Low-Density Lipoprotein Cholesterol Levels for Preventing Stroke Recurrence Clinical Sciences
Conclusions—The composite risk of stroke and transient ischemic attack reduced in the postrandomized LDL cholesterol level of 80 to 100 mg/dL after adjusting for statin usage.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT00221104.
Source: Stroke - March 26, 2018 Category: Neurology Authors: Naohisa Hosomi, Kazuo Kitagawa, Yoji Nagai, Yoko Nakagawa, Shiro Aoki, Tomohisa Nezu, Tatsuo Kagimura, Hirofumi Maruyama, Hideki Origasa, Kazuo Minematsu, Shinichiro Uchiyama, Masayasu Matsumoto Tags: Lipids and Cholesterol, Secondary Prevention, Treatment Original Contributions Source Type: research

Vascular tight junction disruption and angiogenesis in spontaneously hypertensive rat with neuroinflammatory white matter injury.
Abstract Vascular cognitive impairment is a major cause of dementia caused by chronic hypoxia, producing progressive damage to white matter (WM) secondary to blood-brain barrier (BBB) opening and vascular dysfunction. Tight junction proteins (TJPs), which maintain BBB integrity, are lost in acute ischemia. Although angiogenesis is critical for neurovascular remodeling, less is known about its role in chronic hypoxia. To study the impact of TJP degradation and angiogenesis during pathological progression of WM damage, we used the spontaneously hypertensive/stroke prone rats with unilateral carotid artery occlusion ...
Source: Neurobiology of Disease - February 24, 2018 Category: Neurology Authors: Yang Y, Kimura-Ohba S, Thompson JF, Salayandia VM, Cosse M, Raz L, Jalal FY, Rosenberg GA Tags: Neurobiol Dis Source Type: research

Relationship Between Dietary Vitamin D and Deaths From Stroke and Coronary Heart Disease Brief Report
Background and Purpose—There is growing evidence about the importance of vitamin D for cardiovascular health. Therefore, we examined the relationship between dietary vitamin D intake and risk of mortality from stroke and coronary heart disease in Japanese population.Methods—A prospective study encompassing 58 646 healthy Japanese adults (23 099 men and 35 547 women) aged of 40 to 79 years in whom dietary vitamin D intake was determined via a self-administered food frequency questionnaire. The median follow-up period was 19.3 years (1989–2009). The hazard ratios and 95% confidence intervals of mortality were calcu...
Source: Stroke - January 22, 2018 Category: Neurology Authors: Haytham A. Sheerah, Ehab S. Eshak, Renzhe Cui, Hironori Imano, Hiroyasu Iso, Akiko Tamakoshi Tags: Cardiovascular Disease, Diet and Nutrition, Epidemiology, Risk Factors, Cerebrovascular Disease/Stroke Brief Reports Source Type: research

Long-Term Effect of Pravastatin on Carotid Intima-Media Complex Thickness Clinical Sciences
Conclusions—The usual Japanese dose of pravastatin significantly reduced the progression of carotid IMT at 5 years in patients with noncardioembolic stroke.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT00361530.
Source: Stroke - December 22, 2017 Category: Neurology Authors: Masatoshi Koga, Kazunori Toyoda, Kazuo Minematsu, Masahiro Yasaka, Yoji Nagai, Shiro Aoki, Tomohisa Nezu, Naohisa Hosomi, Tatsuo Kagimura, Hideki Origasa, Kenji Kamiyama, Rieko Suzuki, Toshiho Ohtsuki, Hirofumi Maruyama, Kazuo Kitagawa, Shinichiro Uchiyam Tags: Risk Factors, Secondary Prevention, Ultrasound, Atherosclerosis Original Contributions Source Type: research

Clinical Study of Intravenous, Low-Dose Recombinant Tissue Plasminogen Activator for Acute Cerebral Infarction: Comparison of Treatment within 3  Hours versus 3-4.5 Hours
An intravenous recombinant tissue plasminogen activator (rt-PA, alteplase .6  mg/kg) for acute cerebral infarction within 3 hours of onset was approved in Japan in 2005. The treatment window was subsequently extended to within 4.5 hours of onset. However, few Japanese studies have compared the efficacy and safety of rt-PA therapy between patients treated within 3 hou rs and patients treated within 3-4.5 hours.
Source: Journal of Stroke and Cerebrovascular Diseases - December 5, 2017 Category: Neurology Authors: Ichiro Deguchi, Norio Tanahashi, Masaki Takao Source Type: research

ROCK as a therapeutic target for ischemic stroke.
Authors: Sladojevic N, Yu B, Liao JK Abstract INTRODUCTION: Stroke is a major cause of disability and the fifth leading cause of death. Currently, the only approved acute medical treatment of ischemic stroke is tissue plasminogen activator (tPA), but its effectiveness is greatly predicated upon early administration of the drug. There is, therefore, an urgent need to find new therapeutic options for acute stroke. Areas covered: In this review, we summarize the role of Rho-associated coiled-coil containing kinase (ROCK) and its potential as a therapeutic target in stroke pathophysiology. ROCK is a major regulator of cel...
Source: Expert Review of Neurotherapeutics - October 24, 2017 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Association Between Onset-to-Door Time and Clinical Outcomes After Ischemic Stroke Clinical Sciences
Conclusions—Early hospital arrival within 6 hours after stroke onset is associated with favorable outcomes after ischemic stroke, regardless of reperfusion treatment or stroke severity.
Source: Stroke - October 23, 2017 Category: Neurology Authors: Ryu Matsuo, Yuko Yamaguchi, Tomonaga Matsushita, Jun Hata, Fumi Kiyuna, Kenȷi Fukuda, Yoshinobu Wakisaka, Junya Kuroda, Tetsuro Ago, Takanari Kitazono, Masahiro Kamouchi, on behalf of the Fukuoka Stroke Registry Investigators† Tags: Ischemic Stroke Original Contributions Source Type: research

Randomized Controlled Trial of Early Versus Delayed Statin Therapy in Patients With Acute Ischemic Stroke Clinical Sciences
Conclusions—Our randomized trial involving patients with acute ischemic stroke and dyslipidemia did not show any superiority of early statin therapy within 24 hours of admission compared with delayed statin therapy 7 days after admission to alleviate the degree of disability at 90 days after onset.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT02549846.
Source: Stroke - October 23, 2017 Category: Neurology Authors: Shinichi Yoshimura, Kazutaka Uchida, Takashi Daimon, Ryuzo Takashima, Kazuhiro Kimura, Takeshi Morimoto, on behalf of ASSORT Trial Investigator* Tags: Clinical Studies, Lipids and Cholesterol, Treatment, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

Assessment Model to Identify Patients With Stroke With a High Possibility of Discharge to Home Clinical Sciences
Conclusions—We have developed an assessment model for identifying patients with a high possibility of being discharged to their homes after an acute stroke. This model would be useful for health professionals to adequately plan patients’ discharge soon after their admission.
Source: Stroke - September 25, 2017 Category: Neurology Authors: Takahiro Itaya, Yusuke Murakami, Akiko Ota, Eiichi Nomura, Tomoko Fukushima, Masakazu Nishigaki Tags: Epidemiology, Quality and Outcomes Original Contributions Source Type: research

Accessibility to Tertiary Stroke Centers in Hokkaido, Japan: Use of Novel Metrics to Assess Acute Stroke Care Quality
Both the accessibility and availability of stroke specialists are major determinants of patient outcomes following acute ischemic stroke (AIS). The purpose of this study was to implement novel metrics to assess the accessibility of tertiary stroke centers as well as to evaluate regional disparities in stroke specialists.
Source: Journal of Stroke and Cerebrovascular Diseases - September 11, 2017 Category: Neurology Authors: Kensuke Fujiwara, Toshiya Osanai, Eiichi Kobayashi, Takumi Tanikawa, Ken Kazumata, Kikutaro Tokairin, Kiyohiro Houkin, Katsuhiko Ogasawara Source Type: research

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