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Total 37 results found since Jan 2013.

Virtual Screening of the multi-pathway and multi-gene regulatory molecular mechanism of Dachengqi decoction in the treatment of stroke Based on Network Pharmacology.
CONCLUSION: Based on the methods of network pharmacology and GEO analysis, it was found that, during stroke treatment, DCQD regulates and controls multiple genes and multiple pathways in a synergistic manner, providing a new strategy for stroke treatment. PMID: 32160845 [PubMed - as supplied by publisher]
Source: Combinatorial Chemistry and High Throughput Screening - March 10, 2020 Category: Chemistry Authors: Pei L, Shen X, Yan Y, Tan C, Qu K, Zou J, Wang Y, Ping F Tags: Comb Chem High Throughput Screen Source Type: research

Elevated circulating homocysteine and high-sensitivity C-reactive protein jointly predicts post-stroke depression among Chinese patients with acute ischemic stroke.
CONCLUSIONS: Coexistence of both higher HCY and higher hs-CRP in the acute phase of ischemic stroke were associated with subsequent PSD, independently of established conventional risk factors. PMID: 29325799 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - January 8, 2018 Category: Chemistry Authors: Yin J, Zhong C, Zhu Z, Bu X, Xu T, Guo L, Wang X, Zhang J, Cui Y, Li D, Zhang J, Ju Z, Chen CS, Chen J, Zhang Y, He J Tags: Clin Chim Acta Source Type: research

Increased Growth Differentiation Factor 15 Is Associated with Unfavorable Clinical Outcomes of Acute Ischemic Stroke Proteomics and Protein Markers
CONCLUSIONS: High GDF-15 concentrations are independently associated with adverse clinical outcomes of acute ischemic stroke, suggesting that baseline serum GDF-15 could provide additional information to identify ischemic stroke patients at high risk of poor prognosis.
Source: Clinical Chemistry - March 27, 2019 Category: Chemistry Authors: Yin, J., Zhu, Z., Guo, D., Wang, A., Zeng, N., Zheng, X., Peng, Y., Zhong, C., Wang, G., Zhou, Y., Chen, C.-S., Chen, J., Zhang, Y., He, J. Tags: Proteomics and Protein Markers Source Type: research

Molecules, Vol. 27, Pages 3099: The Signaling Pathways and Targets of Natural Compounds from Traditional Chinese Medicine in Treating Ischemic Stroke
This study aims to update and summarize the signaling pathways and targets of natural compounds in the treatment of IS, and provide a base of information for the future development of effective treatments for IS.
Source: Molecules - May 12, 2022 Category: Chemistry Authors: Xing-Hua Li Feng-Ting Yin Xiao-Hang Zhou Ai-Hua Zhang Hui Sun Guang-Li Yan Xi-Jun Wang Tags: Review Source Type: research

Molecules, Vol. 24, Pages 1831: A NMR-Based Metabonomics Approach to Determine Protective Effect of a Combination of Multiple Components Derived from Naodesheng on Ischemic Stroke Rats
This study aimed to investigate the protective effect of the ten-component combination derived from NDS (TCNDS) on ischemic stroke rats with a middle cerebral artery occlusion (MCAO) model by integrating an NMR-based metabonomics approach with biochemical assessment. Our results showed that TCNDS could improve neurobehavioral function, decrease the cerebral infarct area, and ameliorate pathological features in MCAO model rats. In addition, TCNDS was found to decrease plasma lactate dehydrogenase (LDH) and malondialdehyde (MDA) production and increase plasma superoxide dismutase (SOD) production. Furthermore, 1H-NMR metabon...
Source: Molecules - May 12, 2019 Category: Chemistry Authors: Lan Luo Jiazhen Kang Qiong He Yue Qi Xingyu Chen Shumei Wang Shengwang Liang Tags: Article Source Type: research

Exploring Mechanisms of Houshiheisan in Treating Ischemic Stroke with Network Pharmacology and Independent Cascade Model
CONCLUSION: This study advocated potential drug development with targets in the AGE signaling pathway, with emphasis on neuroprotective, anti-inflammatory, and anti-apoptotic functions. The molecular docking simulation indicated that the ligand-target combination selection method based on the IC model was effective and reliable.PMID:37565556 | DOI:10.2174/1386207326666230810094557
Source: Combinatorial Chemistry and High Throughput Screening - August 11, 2023 Category: Chemistry Authors: Bo Cao Jiao Jin Zhiyu Tang Qiong Luo Jinbing An Wei Pang Source Type: research

Molecules, Vol. 27, Pages 7644: Preparation, In Vitro and In Vivo Evaluation of Nanoemulsion In Situ Gel for Transnasal Delivery of Traditional Chinese Medicine Volatile Oil from Ligusticum sinense Oliv.cv. Chaxiong
un Li Guosong Zhang Ischemic stroke is a difficult-to-treat brain disease that may be attributed to a limited therapeutic time window and lack of effective clinical drugs. Nasal–brain administration is characterized by low systemic toxicity and is a direct and non-invasive brain targeting route. Preliminary studies have shown that the volatile oil of Chaxiong (VOC) has an obvious anti-ischemic stroke effect. In this work, we designed a nanoemulsion thermosensitive in situ gel (VOC-NE-ISG) loaded with volatile oil of Chaxiong for ischemia via intranasal delivery to rat brain treatment of cerebral ischemi...
Source: Molecules - November 7, 2022 Category: Chemistry Authors: Chunhui Huang Canjian Wang Wenliu Zhang Tao Yang Mingyan Xia Xiaomeng Lei Ying Peng Yuhuan Wu Jianfang Feng Dongxun Li Guosong Zhang Tags: Article Source Type: research

Natural neuroprotective alkaloids from Stephania japonica (Thunb.) Miers.
Abstract Modulating inflammatory responses after stroke can prevent brain injury and, therefore, improve neurological outcome. Stephania japonica (Thunb.) Miers is a Chinese folk medicine with the function of dispelling the "wind and blockage" in the human body according to the Chinese medicine theory, in which the symptoms of stroke are caused by the "wind and blockage" in the body. In this paper, we for the first time linked S. japonica to stroke by clarifying fifteen alkaloidal constituents including five undescribed (1-5) ones and screening out six hasubanan type alkaloids (1-4, 7, 15) that elicited stronger a...
Source: Bioorganic Chemistry - July 31, 2019 Category: Chemistry Authors: Xiao J, Hao T, Chen G, Song J, Lin B, Li W, Xu J, Liu J, Hou Y, Li N Tags: Bioorg Chem Source Type: research

Acute effects of ambient nitrogen oxides and interactions with temperature on cardiovascular mortality in Shenzhen, China
CONCLUSIONS: Low levels of nitrogen oxides showed acute and adverse impacts and the interactive roles of temperature on cardiovascular mortality. Cumulative effects were most significant and joint effects of nitrogen oxides required more attention. Population under 65 years old and population with stroke-related health condition were susceptible, especially days at lower temperature.PMID:34826935 | DOI:10.1016/j.chemosphere.2021.132255
Source: Chemosphere - November 27, 2021 Category: Chemistry Authors: Panjun Gao Yongsheng Wu Lihuan He Li Wang Yingbin Fu Fengying Zhang Thomas Krafft Pim Martens Source Type: research

Molecules, Vol. 23, Pages 1747: Preparation, Characterization, Pharmacokinetics and Biodistribution of Baicalin-Loaded Liposome on Cerebral Ischemia-Reperfusion after i.v. Administration in Rats
In conclusion, BA-LP might be a potential drug delivery system to improve the therapeutic efficacy of BA. In addition, these results also suggest that the pathological damages of ischemia-reperfusion have a significant impact on the pharmacokinetic traits of BA.
Source: Molecules - July 17, 2018 Category: Chemistry Authors: Nan Li Lingling Feng Yujun Tan Yan Xiang Ruoqi Zhang Ming Yang Tags: Article Source Type: research