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Cost-effectiveness of endovascular thrombectomy with alteplase versus endovascular thrombectomy alone for acute ischemic stroke secondary to large vessel occlusion
CMAJ Open. 2023 May 16;11(3):E443-E450. doi: 10.9778/cmajo.20220096. Print 2023 May-Jun.ABSTRACTBACKGROUND: Recent randomized trials have suggested that endovascular thrombectomy (EVT) alone may provide similar functional outcomes as the current standard of care, EVT combined with intravenous alteplase treatment, for acute ischemic stroke secondary to large vessel occlusion. We conducted an economic evaluation of these 2 therapeutic options.METHODS: We constructed a decision analytic model with a hypothetical cohort of 1000 patients to assess the cost-effectiveness of EVT with intravenous alteplase treatment versus EVT alo...
Source: cmaj - May 16, 2023 Category: General Medicine Authors: Zhikang Ye Ting Zhou Mengmeng Zhang Junwen Zhou Feng Xie Michael D Hill Eric E Smith Jason W Busse Yi Zhang Ying Liu Xin Wang Zhuo Ma Zhuoling An Source Type: research

Effect of direct endovascular treatment versus standard bridging therapy in large artery anterior circulation stroke (DEVT): 18-month follow-up of a randomized controlled trial
We reporte...
Source: BMC Neurology - February 27, 2023 Category: Neurology Authors: Zhongfan Ruan, Xiaojun Luo, Yongkang Liu, Fengli Li, Jincheng Liu and Wenjie Zi Tags: Research Source Type: research

Low-dose vs. standard-dose alteplase for Chinese patients with acute ischemic stroke: A propensity score analysis
ConclusionsLow-dose alteplase was related to a poor functional outcome without lowering the risk of sICH, compared with standard-dose alteplase for AIS patients in China.
Source: Frontiers in Neurology - February 21, 2023 Category: Neurology Source Type: research

Cost-effectiveness of thrombectomy alone versus alteplase before thrombectomy in acute ischemic stroke: results from the DIRECT-MT
CONCLUSIONS: In this economic analysis based on a trial conducted in China, the authors found that EVT alone was not associated with economic dominance over EVT+IVT in patients with anterior circulation large-vessel occlusion.PMID:36790013 | DOI:10.3171/2022.12.JNS221791
Source: Journal of Neurosurgery - February 15, 2023 Category: Neurosurgery Authors: Hongyu Ma Yu Zhou Lan Gao Pei Liu Lei Zhang Pengfei Xing Zifu Li Hongjian Shen Hongjian Zhang Yongxin Zhang Xiaoxi Zhang Weilong Hua Yongwei Zhang Jianmin Liu Congguo Yin Pengfei Yang Direct-MT investigators Source Type: research

Economic evaluation of intravenous alteplase for stroke with the time of onset between 4.5 and 9 hours
Conclusion For patients with AIS with a time of onset between 4.5 and 9 hours, perfusion imaging-guided intravenous alteplase was likely to be cost-effective in China and was cost-effective in the US when compared with placebo.
Source: Journal of NeuroInterventional Surgery - December 14, 2022 Category: Neurosurgery Authors: Chen, J., Liang, X., Tong, X., Han, M., Ji, L., Zhao, S., Hu, Z., Liu, A. Tags: Open access, Socioeconomics Source Type: research

Mild and moderate cardioembolic stroke patients may benefit more from direct mechanical thrombectomy than bridging therapy: A subgroup analysis of a randomized clinical trial (DIRECT-MT)
ConclusionMild and moderate cardioembolic stroke patients may benefit more from direct mechanical thrombectomy than bridging therapy. This need to be confirmed by further prospective studies in a larger number of patients.
Source: Frontiers in Neurology - November 24, 2022 Category: Neurology Source Type: research

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