Filtered By:
Specialty: Nanotechnology
This page shows you your search results in order of date. This is page number 18.
Order by Relevance | Date
Total 382 results found since Jan 2013.
Efficient delivery of therapeutic siRNA into glioblastoma cells using multifunctional dendrimer-entrapped gold nanoparticles
Nanomedicine Ahead of Print.
Source: Future Medicine: Nanomedicine - November 3, 2016 Category: Nanotechnology Authors: Lingdan Kong Yilun Wu Carla S Alves Xiangyang Shi Source Type: research
A drug-delivery strategy for overcoming drug resistance in breast cancer through targeting of oncofetal fibronectin
Publication date: Available online 19 October 2016 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Phei Er Saw, Jinho Park, Sangyong Jon, Omid C. Farokhzad A major problem with cancer chemotherapy begins when cells acquire resistance. Drug-resistant cancer cells typically upregulate multi-drug resistance proteins such as P-glycoprotein (P-gp). However, the lack of overexpressed surface biomarkers has limited the targeted therapy of drug-resistant cancers. Here we report a drug-delivery carrier decorated with a targeting ligand for a surface marker protein Extra-domain B(EDB) specific to drug-resistant...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - October 28, 2016 Category: Nanotechnology Source Type: research
Targeted Co ‐delivery of PTX and TR3 siRNA by PTP Peptide Modified Dendrimer for the Treatment of Pancreatic Cancer
A new type of tumor‐targeted nanovehicle peptide‐conjugated PSPG (PSPGP) is successfully synthesized for co‐delivery of paclitaxel (PTX) and TR3 small interfering RNA (siRNA). In vitro and in vivo investigations demonstrate that the redox‐responsive PSPGP exhibit enhanced endosomal escape and intracellular degradation, which facilitate PTX and TR3 siRNA release, effectively improving the antitumor efficacy.
Source: Small - October 19, 2016 Category: Nanotechnology Authors: Yang Li, Hebin Wang, Kai Wang, Qinglian Hu, Qi Yao, Youqing Shen, Guocan Yu, Guping Tang Tags: Communication Source Type: research
pH-Sensitive Nanomicelles for High-Efficiency siRNA
Delivery in Vitro and in Vivo: An Insight into the Design of Polycations
with Robust Cytosolic Release
Nano LettersDOI: 10.1021/acs.nanolett.6b02915
Source: Nano Letters - October 17, 2016 Category: Nanotechnology Authors: Junhui Zhou, Yidi Wu, Changrong Wang, Qiang Cheng, Shangcong Han, Xiaoxia Wang, Jianhua Zhang, Liandong Deng, Deyao Zhao, Lili Du, Huiqing Cao, Zicai Liang, Yuanyu Huang and Anjie Dong Source Type: research
Single-Step Microfluidic Synthesis of Transferrin-Conjugated Lipid Nanoparticles for siRNA Delivery
In this study, a single-step process based on microfluidic focusing (MF) was employed to synthesize transferrin-conjugated lipid nanoparticles (Tf-LNPs) and the method was compared with a multi-steps bulk mixing (BM) method. The results indicate that this single-step MF process enables rapid and efficient synthesis of Tf-LNPs, which were named Tf-LNPs-MF. Tf-LNPs-MF was shown to have a smaller size and more uniform structures compared to LNPs produced by multi-steps BM method (Tf-LNPs-BM). Furthermore, efficient cellular uptake of Tf-LNPs-MF in vitro as well as greater tumor inhibition in vivo proved that Tf-LNPs-MF had hi...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - October 9, 2016 Category: Nanotechnology Source Type: research
RNAi Screening of the Glucose-Regulated Chaperones
in Cancer with Self-Assembled siRNA Nanostructures
Nano LettersDOI: 10.1021/acs.nanolett.6b02274
Source: Nano Letters - October 3, 2016 Category: Nanotechnology Authors: Mayurbhai R. Patel, Stephen D. Kozuch, Christopher N. Cultrara, Reeta Yadav, Suiying Huang, Uri Samuni, John Koren, Gabriela Chiosis and David Sabatino Source Type: research
Mussel Adhesion ‐Inspired Reverse Transfection Platform Enhances Osteogenic Differentiation and Bone Formation of Human Adipose‐Derived Stem Cells
Using small interfering RNA (siRNA) to regulate gene expression is an emerging strategy for stem cell manipulation to improve stem cell therapy. However, conventional methods of siRNA delivery into stem cells based on solution‐mediated transfection are limited due to low transfection efficiency and insufficient duration of cell‐siRNA contact during lengthy culturing protocols. To overcome these limitations, a bio‐inspired polymer‐mediated reverse transfection system is developed consisting of implantable poly(lactic‐co‐glycolic acid) (PLGA) scaffolds functionalized with siRNA‐lipidoid nanoparticle (sLNP) comp...
Source: Small - September 25, 2016 Category: Nanotechnology Authors: Jisoo Shin, Jung Ho Cho, Yoonhee Jin, Kisuk Yang, Jong Seung Lee, Hyun ‐Ji Park, Hyung‐Seop Han, Jinkyu Lee, Hojeong Jeon, Heungsoo Shin, Seung‐Woo Cho Tags: Full Paper Source Type: research
Nanobiotechnology: (Small 34/2016)
The State Key Laboratory of Biochemical Engineering (SKLBE) in the Institute of Processing Engineering, CAS is highlighted on the back cover. The laboratory has established micro‐pore emulsification, multi‐shell formation and self‐assembly technologies to bring great advances in nanobiotechnology. The developed nanoparticles or devices, with uniform‐sizes and controlled structures, have exerted themselves in the fundamental research as well as the industrial applications on enzyme immobilization, high‐throughput protein separation medium, controlled release and targeted diagnoses, and delivery of antigens, siRNA,...
Source: Small - September 6, 2016 Category: Nanotechnology Tags: Back Cover Source Type: research
Recent advances of using polyhydroxyalkanoate ‐based nanovehicles as therapeutic delivery carriers
Polyhydroxyalkanoates (PHAs) are a class of diverse biodegradable polyesters that can be produced either by natural bioconversion process or by chemical synthesis via the ring‐opening polymerization of β‐lactones. Because of the excellent biodegradability and biocompatibility, the development of PHA‐based nanovehicles as therapeutic delivery carriers, including nanoparticles, micelles, liposomes, and vesicles, has received considerable attention in recent years, and these sophisticated materials have demonstrated significant impact on the drug bioavailability, better encapsulation, and less toxic properties of biode...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - August 31, 2016 Category: Nanotechnology Authors: Zibiao Li, Xian Jun Loh Tags: Advanced Review Source Type: research
Folate-targeted amphiphilic cyclodextrin.siRNA nanoparticles for prostate cancer therapy exhibit PSMA mediated uptake, therapeutic gene silencing in vitro and prolonged circulation in vivo
This study highlights the ability of incorporating a folate ligand into CD.siRNA nanoparticles to allow for targeted delivery of siRNA to prostate cancer cells via the PSMA. Graphical abstract
Source: Nanomedicine: Nanotechnology, Biology and Medicine - August 27, 2016 Category: Nanotechnology Source Type: research
Liposome-polyethylenimine complexes (DPPC-PEI lipopolyplexes) for therapeutic siRNA delivery in vivo
Therapeutic applications of RNA interference (RNAi) require efficient siRNA delivery strategies in vivo. Combining lipid-based carriers with polymeric nanoparticles offers the favourable properties of both systems. This is the first study to explore polyethylenimine-based lipopolyplexes comprising a low-molecular weight PEI and the phospholipid DPPC for therapeutic siRNA use. Lipopolyplex structures are analysed by electron microscopy. Biological efficacies are demonstrated in vitro by cellular uptake, knockdown of the target oncogene survivin and concomitant cell growth inhibition.
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - August 20, 2016 Category: Nanotechnology Authors: Alexander Ewe, Omkar Panchal, Shashank Reddy Pinnapireddy, Udo Bakowsky, Susanne Przybylski, Achim Temme, Achim Aigner Source Type: research
Optimization of Transforming Growth Factor- & #946;1 siRNA Loaded Chitosan-Tripolyphosphate Nanoparticles for the Treatment of Colorectal Cancer Hepatic Metastasis in a Mouse Model
Source: Journal of Biomedical Nanotechnology - July 21, 2016 Category: Nanotechnology Authors: Fang, Jian-Kai Chen, Liang Lu, Xue-Guan Cao, Dan Guo, Ling-Ling Zhang, Yong-Sheng Li, Liu-Bing Zhang, Li-Feng Kuang, Yu-Ting Wang, Shou-Li Tags: Research Articles Source Type: research
