Targeted Co ‐delivery of PTX and TR3 siRNA by PTP Peptide Modified Dendrimer for the Treatment of Pancreatic Cancer

A new type of tumor‐targeted nanovehicle peptide‐conjugated PSPG (PSPGP) is successfully synthesized for co‐delivery of paclitaxel (PTX) and TR3 small interfering RNA (siRNA). In vitro and in vivo investigations demonstrate that the redox‐responsive PSPGP exhibit enhanced endosomal escape and intracellular degradation, which facilitate PTX and TR3 siRNA release, effectively improving the antitumor efficacy.

Source: Small - October 19, 2016 Category: Nanotechnology Authors: Yang Li, Hebin Wang, Kai Wang, Qinglian Hu, Qi Yao, Youqing Shen, Guocan Yu, Guping Tang Tags: Communication Source Type: research