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A case of undifferentiated carcinoma of the bladder treated by combination therapy of surgery, local radiation, and immune checkpoint inhibitors
We present the case of an 81-year-old woman complaining of bladder irritation. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed a bulky bladder tumor, which was diagnosed as cT4aN0M0. A transurethral resection of the bladder tumor revealed pT2 or higher urothelial carcinoma. The patient underwent total cystectomy with an ileal conduit diversion. Histological examination revealed a primary undifferentiated bladder carcinoma with a sarcoma component, pT3aN0M0. Postoperative adjuvant chemotherapy with gemcitabine plus carboplatin was administered. However, this regimen was discontinued after one course d...
Source: Nagoya Journal of Medical Science - December 22, 2022 Category: International Medicine & Public Health Authors: Wataru Nakane Yushi Naito Koya Morishita Kazuna Matsuo Shohei Ishida Yoshihisa Matsukawa Source Type: research

What determines continuing grey matter changes in first-episode schizophrenia and affective psychosis?
Conclusions. Our results suggest that the progression of brain abnormalities in FEP subjects is restricted to those with a poor outcome and differs between diagnosis subgroups. AP intake is associated with a different pattern of GM reductions over time. PMID: 25180801 [PubMed - as supplied by publisher]
Source: Psychological Medicine - September 2, 2014 Category: Psychiatry Authors: Rosa PG, Zanetti MV, Duran FL, Santos LC, Menezes PR, Scazufca M, Murray RM, Busatto GF, Schaufelberger MS Tags: Psychol Med Source Type: research

The continuing story of schizophrenia and schizoaffective disorder: One condition or two?
This study asked whether schizophrenia and schizoaffective disorder are distinguishable on selected cognitive, social cognitive and structural social brain measures. Outpatients with a diagnosis of schizophrenia (n = 44) or schizoaffective disorder (n = 29) and non-psychiatric control participants (n = 62) were studied. Patients were assessed clinically (Positive and Negative Syndrome Scale) and all participants were administered a battery of cognitive (MATRICS Consensus Cognitive Battery; Wechsler Abbreviated Scale of Intelligence, Wide Range Achievement Reading) and social cognitive (Reading the Mind in the E...
Source: Schizophrenia Research: Cognition - February 11, 2019 Category: Psychiatry Source Type: research

Renal Cancer is Not Radioresistant: Slowly but Continuing Shrinkage of the Tumor After Stereotactic Body Radiation Therapy.
CONCLUSION:: All renal tumors decreased in size slowly but continuously for years after stereotactic body radiation therapy. Renal cancer can be treated radically with stereotactic body radiation therapy as a radiosensitive tumor, but careful attention should be given in cases with solitary kidney. PMID: 30803362 [PubMed - in process]
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: Funayama S, Onishi H, Kuriyama K, Komiyama T, Marino K, Araya M, Saito R, Aoki S, Maehata Y, Nonaka H, Tominaga L, Muramatsu J, Nakagomi H, Kamiyama M, Takeda M Tags: Technol Cancer Res Treat Source Type: research

UNet++: Redesigning Skip Connections to Exploit Multiscale Features in Image Segmentation
The state-of-the-art models for medical image segmentation are variants of U-Net and fully convolutional networks (FCN). Despite their success, these models have two limitations: (1) their optimal depth is apriori unknown, requiring extensive architecture search or inefficient ensemble of models of varying depths; and (2) their skip connections impose an unnecessarily restrictive fusion scheme, forcing aggregation only at the same-scale feature maps of the encoder and decoder sub-networks. To overcome these two limitations, we propose UNet++, a new neural architecture for semantic and instance segmentation, b...
Source: IEE Transactions on Medical Imaging - May 31, 2020 Category: Biomedical Engineering Source Type: research