A systematic review of moderators of cognitive remediation response for people with schizophrenia
ConclusionsThere was no high-quality replicated evidence which identifies reliable moderators of CR response. Many moderators were not replicated or presented in single, underpowered studies. Studies also investigated moderators independently despite their potential to overlap (e.g. age and education). Future research should concentrate on evaluating, with sound studies, the role moderators may play in affecting CR treatment response. This information can inform who will benefit most from the therapy and help to improve the benefits of CR. (Source: Schizophrenia Research: Cognition)
Source: Schizophrenia Research: Cognition - September 6, 2019 Category: Psychiatry Source Type: research

Non-literal understanding and psychosis: Metaphor comprehension in individuals with a diagnosis of schizophrenia
Publication date: December 2019Source: Schizophrenia Research: Cognition, Volume 18Author(s): Felicity Deamer, Ellen Palmer, Quoc C. Vuong, Nicol Ferrier, Andreas Finkelmeyer, Wolfram Hinzen, Stuart WatsonAbstractPrevious studies suggest that understanding of non-literal expressions, and in particular metaphors, can be impaired in people with schizophrenia; although it is not clear why. We explored metaphor comprehension capacity using a novel picture selection paradigm; we compared task performance between people with schizophrenia and healthy comparator subjects and we further examined the relationships between the abili...
Source: Schizophrenia Research: Cognition - August 27, 2019 Category: Psychiatry Source Type: research

Determinants of occupational outcome in recent-onset psychosis: The role of cognition
Publication date: December 2019Source: Schizophrenia Research: Cognition, Volume 18Author(s): William Pothier, Caroline Cellard, Marc Corbière, Patrizia Villotti, Amélie M. Achim, Andréanne Lavoie, Mélissa Turcotte, Chantal Vallières, Marc-André RoyAbstractWorking or studying is a common goal among people with recent-onset psychosis. Cognitive deficits have been reported to influence occupational outcome, but to date few studies have evaluated if cognitive deficits independently predict occupational outcome when taking into account other important determinants, such as self-esteem,...
Source: Schizophrenia Research: Cognition - August 21, 2019 Category: Psychiatry Source Type: research

A comparison of compensatory and restorative cognitive interventions in early psychosis
This study concluded that both CAT and ABCR hold promise as interventions for early intervention psychosis populations but more work is needed to identify illness severity, subtype and contextual considerations that might indicate an emphasis on more compensatory versus more restorative cognitive interventions. (Source: Schizophrenia Research: Cognition)
Source: Schizophrenia Research: Cognition - July 24, 2019 Category: Psychiatry Source Type: research

Approaches to attenuated psychosis syndrome treatments: A perspective on the regulatory issues
Publication date: December 2019Source: Schizophrenia Research: Cognition, Volume 18Author(s): Luca Pani, Richard S.E. Keefe (Source: Schizophrenia Research: Cognition)
Source: Schizophrenia Research: Cognition - June 15, 2019 Category: Psychiatry Source Type: research

Publisher's Note
Publication date: September 2019Source: Schizophrenia Research: Cognition, Volume 17Author(s): (Source: Schizophrenia Research: Cognition)
Source: Schizophrenia Research: Cognition - May 29, 2019 Category: Psychiatry Source Type: research

Affective prosody and facial emotion recognition in first-episode schizophrenia: Associations with functioning & symptoms
This study aimed to examine how facial emotion and affective prosody recognition are related to functioning and symptoms in a first-episode schizophrenia sample. Further, in light of research suggesting variable emotion-specific performance in people with schizophrenia, this study explored emotion-specific performance. Participants were 49 people with a recent first episode of schizophrenia taking part in a larger RCT. Results revealed that affective prosody recognition was significantly correlated with both role and social functioning. Regarding associations with psychiatric symptoms, facial emotion recognition was signif...
Source: Schizophrenia Research: Cognition - May 26, 2019 Category: Psychiatry Source Type: research

Motivation and engagement during cognitive training for schizophrenia spectrum disorders
ConclusionsObjective measures of treatment engagement were better predictors of treatment outcomes than subjective measures of motivation. Homework completion was most strongly related to treatment outcomes and mediated the relationship between session attendance and treatment outcomes, suggesting continued engagement with cognitive stimulation may be an especially important component of cognitive remediation programs. Future research should examine methods to improve homework completion and session attendance to maximize therapeutic outcomes. (Source: Schizophrenia Research: Cognition)
Source: Schizophrenia Research: Cognition - May 23, 2019 Category: Psychiatry Source Type: research

Metacognition over time is related to neurocognition, social cognition, and intrapsychic foundations in psychosis
In conclusion, over time, improvements in metacognition across domains co-occur with other core cognitive and social capacities in persons with schizophrenia. As persons became better able to form integrated senses of themselves and adaptively use this knowledge, improvements in neurocognition, social cognition, and intrapsychic foundations were also present. (Source: Schizophrenia Research: Cognition)
Source: Schizophrenia Research: Cognition - May 17, 2019 Category: Psychiatry Source Type: research

Functional deficits in attenuated psychosis syndrome and related conditions: Current and future treatment options
Publication date: September 2019Source: Schizophrenia Research: Cognition, Volume 17Author(s): Philip D. Harvey, Mackenzie Taylor Jones (Source: Schizophrenia Research: Cognition)
Source: Schizophrenia Research: Cognition - May 17, 2019 Category: Psychiatry Source Type: research

Training engagement, baseline cognitive functioning, and cognitive gains with computerized cognitive training: A cross-diagnostic study
Publication date: Available online 13 May 2019Source: Schizophrenia Research: CognitionAuthor(s): Philip D. Harvey, Alexandra M. Balzer, Raymond J. KotwickiAbstractComputerized cognitive training (CCT) interventions are increasing in their use in outpatient mental health settings. These interventions have demonstrated efficacy for improving functional outcomes when combined with rehabilitation interventions. It has recently been suggested that patients with more cognitive impairment have a greater therapeutic response and that reduced engagement in training can identify cases who manifest low levels of benefit from treatme...
Source: Schizophrenia Research: Cognition - May 14, 2019 Category: Psychiatry Source Type: research

What variables predict cognitive remediation associated improvement in individuals with psychosis?
Publication date: Available online 1 May 2019Source: Schizophrenia Research: CognitionAuthor(s): Joanna M. Fiszdon, Matthew M. Kurtz, Lori Parente, Jimmy ChoiAbstractOn average, cognitive remediation (CR) is effective in improving cognitive function in individuals with psychosis, though there is considerable variability in treatment response. No consensus has emerged to date about the potential influence of patient and illness characteristics on CR efficacy. In the current analyses, we examined baseline demographic, cognitive, clinical, and functional ability variables as potential moderators of cognitive improvements duri...
Source: Schizophrenia Research: Cognition - May 3, 2019 Category: Psychiatry Source Type: research

Cognitive and metacognitive factors predict engagement in employment in individuals with first episode psychosis
This study assessed whether metacognition, intellectual aptitude and functional capacity can predict engagement in work and number of hours of work within FEP.MethodsFifty-two individuals with psychosis, from an Early Intervention in Psychosis service, completed measures of IQ, metacognition (Metacognitive Assessment Interview), functional capacity (UPSA), and functional outcome (hours spent in structured activity per week, including employment).ResultsTwenty-six participants (22 males, 4 females) were employed and twenty-six (22 males, 4 females) were not employed. IQ and metacognition were significantly associated with w...
Source: Schizophrenia Research: Cognition - May 3, 2019 Category: Psychiatry Source Type: research

The role of genetics in cognitive remediation in schizophrenia: A systematic review
Publication date: Available online 1 May 2019Source: Schizophrenia Research: CognitionAuthor(s): Rafael Penadés, Marta Bosia, Rosa Catalán, Marco Spangaro, Clemente García-Rizo, Silvia Amoretti, Miquel Bioque, Miquel BernardoAbstractThe role of genetics in cognitive remediation therapies in schizophrenia has not been completely understood yet. Different genes involved in neurotrophic, dopaminergic and serotonin systems have reported to influence cognitive functioning in schizophrenia. These genetic factors could also be contributing to the variability in responsiveness to cognitive treatments. No compr...
Source: Schizophrenia Research: Cognition - May 1, 2019 Category: Psychiatry Source Type: research

Metacognitive function and fragmentation in schizophrenia: Relationship to cognition, self-experience and developing treatments
We describe the rationale and support for one method for quantifying metacognition and its potential to study the fragmentation of a person's sense of themselves, others and the relative place of themselves and others in the larger human community. We summarize research using that method which suggests that deficits in metacognition commonly occur in schizophrenia and are related to basic neurobiological indices of brain functioning. We also present findings indicating that the capacity for metacognition in schizophrenia is positively related to a broad range of aspects of psychological and social functioning when measured...
Source: Schizophrenia Research: Cognition - April 26, 2019 Category: Psychiatry Source Type: research

The synergistic benefits of physical and cognitive exercise in schizophrenia: Promoting motivation to enhance community effectiveness
We present the first community effectiveness data for PE and CT that included a motivationally-enhancing, self-determined approach to exercise, in lieu of participant payment. Eighty-five outpatients with schizophrenia attending an intensive outpatient program were randomized to 18 h of either (A) self-determined PE regimen with choice from a menu of different activities; (B) tablet-based neurofeedback CT focused on processing speed (PS) and working memory (WM), or (C) a time-matched combination of PE and CT. Assessments were conducted at baseline, post, and follow-up (2 mo). All groups improved in WM from baseline to ...
Source: Schizophrenia Research: Cognition - April 26, 2019 Category: Psychiatry Source Type: research

Assessing the potential of longitudinal smartphone based cognitive assessment in schizophrenia: A naturalistic pilot study
DiscussionIt is feasible for those with schizophrenia to use their own smartphones to complete cognitive assessments and other measures related to their mental health. While we did not investigate the correlations between these cognitive assessments and other smartphone captured metrics like step count or self-reported symptoms, the potential to longitudinally assess cognition in the context of patients' environments outside of the clinic presents unique opportunities for characterizing cognitive burden in schizophrenia. (Source: Schizophrenia Research: Cognition)
Source: Schizophrenia Research: Cognition - April 19, 2019 Category: Psychiatry Source Type: research

Differential improvement of negative-symptom subfactors after cognitive remediation in low-functioning individuals with schizophrenia
This study used the model of expressive and experiential negative symptoms subfactors to decrease this heterogeneity. It examined these subfactors and cognition before and after treatment with computerized cognitive remediation training (CRT) in chronically-hospitalized individuals with psychosis and predominant negative symptoms.MethodsSeventy-eight adult participants with a DSM-IV-TR diagnosis of schizophrenia or schizoaffective disorder were enrolled in a 12-week CRT program. Assessments of demographic and illness variables, baseline and endpoint assessments of psychopathology (Positive and Negative Syndrome Scale) and ...
Source: Schizophrenia Research: Cognition - April 18, 2019 Category: Psychiatry Source Type: research

Emotion-specific performance across empathy tasks in schizophrenia: Influence of metacognitive capacity
This study aimed to: 1) examine emotion-specific performance on an empathy task, and 2) elucidate associations with four metacognitive domains: self-reflectivity, understanding of others' minds, decentration, and mastery. Fifty-seven people with schizophrenia or schizoaffective disorder participated. All were administered a computerized, performance-based measure of empathy and an interview-based measure of metacognitive capacity. Results revealed that, consistent with research on facial affect recognition, participants performed significantly better when recognizing happiness in empathic stimuli than all other emotions. R...
Source: Schizophrenia Research: Cognition - April 18, 2019 Category: Psychiatry Source Type: research

Metacognition moderates the relationship between self-reported and clinician-rated motivation in schizophrenia
DiscussionMetacognition appears to be a key variable impacting the strength of the relationship between self-reported and clinician-rated motivation measures and may help to partly explain the varied relationships observed in prior work. Using a metacognitive framework to guide assessment interviews and targeting metacognition in psychosocial treatments may help to improve the synchrony between self-perceptions and clinician ratings of motivation. (Source: Schizophrenia Research: Cognition)
Source: Schizophrenia Research: Cognition - April 18, 2019 Category: Psychiatry Source Type: research

Visualizing mental representations in schizophrenia patients: A reverse correlation approach
Conclusion: These novel findings provide a proof of principle that the reverse correlation technique can be applied to investigate mental representations in schizophrenia patients. (Source: Schizophrenia Research: Cognition)
Source: Schizophrenia Research: Cognition - April 7, 2019 Category: Psychiatry Source Type: research

Social skills, executive functioning and social engagement
Publication date: September 2019Source: Schizophrenia Research: Cognition, Volume 17Author(s): Nir Madjar, Elena Chubarov, Gil Zalsman, Mark Weiser, Gal ShovalAbstractThe study explored hypothesized mediation of social interaction skills between executive functions and social engagement among adolescents diagnosed with schizophrenia. Participants (N = 92; 62% boys; age = 16.8) were assessed four weeks after hospitalization using previously validated scales. A regression mediation analysis followed by Structural Equation Modeling (SEM; with bootstrap analysis) supported the hypothesis. Executive functions were signi...
Source: Schizophrenia Research: Cognition - April 6, 2019 Category: Psychiatry Source Type: research

Cognitive impairment and its improvement after six months in adolescents with schizophrenia
ConclusionsWe observed cognitive impairments on schizophrenic adolescents, which improved after six months of treatment in almost all domains. (Source: Schizophrenia Research: Cognition)
Source: Schizophrenia Research: Cognition - March 27, 2019 Category: Psychiatry Source Type: research

Association of genetic variants at 22q11.2 chromosomal region with cognitive performance in Japanese patients with schizophrenia
Publication date: Available online 26 March 2019Source: Schizophrenia Research: CognitionAuthor(s): Kazufumi Akiyama, Atsushi Saito, Satoshi Saito, Yuji Ozeki, Takashi Watanabe, Kumiko Fujii, Kazutaka ShimodaAbstract22q11.2 heterozygous multigene deletions confer an increased risk of schizophrenia with marked impairment of cognition. We explored whether genes on 22q11.2 are associated with cognitive performance in patients with idiopathic schizophrenia. A total of 240 schizophrenia patients and 240 healthy controls underwent the Japanese-language version of the Brief Assessment of Cognition in Schizophrenia (BACS) and were...
Source: Schizophrenia Research: Cognition - March 26, 2019 Category: Psychiatry Source Type: research

Disturbed time experience during and after psychosis
Publication date: Available online 21 March 2019Source: Schizophrenia Research: CognitionAuthor(s): D.H.V. Vogel, T. Beeker, T. Haidl, C. Kupke, M. Heinze, K. VogeleyAbstractDisturbances in time experience have been argued to play a significant, if not causative role in the clinical presentation of schizophrenia. Phenomenological considerations suggest a fragmented or dis-articulated time experience causing both primary symptoms such as hallucinations, delusions, and self-disorders, as well as an intersubjective desynchronization. We employed content analysis on material collected from patients diagnosed with schizophrenia...
Source: Schizophrenia Research: Cognition - March 21, 2019 Category: Psychiatry Source Type: research

The continuing story of schizophrenia and schizoaffective disorder: One condition or two?
This study asked whether schizophrenia and schizoaffective disorder are distinguishable on selected cognitive, social cognitive and structural social brain measures. Outpatients with a diagnosis of schizophrenia (n = 44) or schizoaffective disorder (n = 29) and non-psychiatric control participants (n = 62) were studied. Patients were assessed clinically (Positive and Negative Syndrome Scale) and all participants were administered a battery of cognitive (MATRICS Consensus Cognitive Battery; Wechsler Abbreviated Scale of Intelligence, Wide Range Achievement Reading) and social cognitive (Reading the Mind in the E...
Source: Schizophrenia Research: Cognition - February 11, 2019 Category: Psychiatry Source Type: research

Confidence, performance, and accuracy of self-assessment of social cognition: A comparison of schizophrenia patients and healthy controls
This study examines the correlations between performance on a social cognitive test, confidence in performance, effort allocated to the task, and correlates of confidence in patients with schizophrenia and healthy controls (HC). Measures included self-reports of depression, social cognitive ability, and social functioning. A performance-based emotion recognition test assessed social cognitive performance and provided the basis for confidence judgments. Although schizophrenia patients had reduced levels of overall confidence, there was a substantial subset of schizophrenic patients who manifested extreme overconfidence and ...
Source: Schizophrenia Research: Cognition - February 8, 2019 Category: Psychiatry Source Type: research

Limited changes in activities of daily life performance ability among people with schizophrenia at clinical settings and the factors moderating the changes
ConclusionsImpairment of ADL ability is recalcitrant in schizophrenia. The improvement was modest and occurred only in a proportion of participants. However, promisingly, chronic illness, low baseline ADL ability, treatment with clozapine and presence of treatment-resistant schizophrenia did not have an adverse effect on the outcome. (Source: Schizophrenia Research: Cognition)
Source: Schizophrenia Research: Cognition - January 17, 2019 Category: Psychiatry Source Type: research

Modified Work Behavior Inventory assessment: Evaluation of psychometric properties
Publication date: June 2019Source: Schizophrenia Research: Cognition, Volume 16Author(s): Jason E. Peer, Joanna E. Strong Kinnaman, Wendy N. TenhulaAbstractThe Work Behavior Inventory (WBI) is a widely used and validated assessment of work functioning in people with schizophrenia. WBI ratings are based on workplace observation and interview with work supervisors. Workplace observation may not be acceptable in all employment settings. A WBI assessment based only on supervisor interview may offer more utility. The current study evaluated the psychometric properties of a modified WBI among individuals with schizophrenia parti...
Source: Schizophrenia Research: Cognition - January 10, 2019 Category: Psychiatry Source Type: research

Neurological soft signs (NSS) and cognitive impairment in chronic schizophrenia
Publication date: June 2019Source: Schizophrenia Research: Cognition, Volume 16Author(s): Christina J. Herold, Céline Z. Duval, Marc M. Lässer, Johannes SchröderAbstractRecent studies indicate that neurological soft signs (NSS) in schizophrenia are associated with generalized cognitive impairments rather than changes in specific neuropsychological domains. However, the majority of studies solely included first-episode patients or patients with a remitting course and did not consider age, course, education or severity of global cognitive deficits as potential confounding variables. Therefore, we examined NS...
Source: Schizophrenia Research: Cognition - December 22, 2018 Category: Psychiatry Source Type: research

The role of childhood trauma in cognitive performance in schizophrenia and bipolar disorder – A systematic review
Publication date: June 2019Source: Schizophrenia Research: Cognition, Volume 16Author(s): Maria R. Dauvermann, Gary DonohoeAbstractChildhood trauma (CT) has repeatedly been associated with cognitive deficits in patients with psychosis but many inconsistencies have been reported so that the nature of the relationship remains unclear. The purpose of this review was to better characterize the contribution of CT to cognitive deficits by considering the type, severity and frequency of childhood traumatic events and their relationships with psychosis at all stages.Relevant studies were identified via electronic and manual litera...
Source: Schizophrenia Research: Cognition - December 12, 2018 Category: Psychiatry Source Type: research

Cannabis acute use impacts symptoms and functionality in a cohort of antipsychotic naïve First Episode of Psychosis individuals
DiscussionThe acute use of cannabis influenced the clinical presentation at our FEP baseline assessment, but did not to influence symptoms or functional outcomes at 10-week follow-up. Additionally, acute cannabis users had a better response for excitement and positive symptoms. Higher excitement symptoms at presentation of FEP should raise concerns of possible acute use of cannabis. Longer follow-up times may elucidate whether the effects on functionality would be more evident later in disease development. (Source: Schizophrenia Research: Cognition)
Source: Schizophrenia Research: Cognition - December 12, 2018 Category: Psychiatry Source Type: research

From “under” to “over” social cognition in schizophrenia: Is there distinct profiles of impairments according to negative and positive symptoms?
Publication date: March 2019Source: Schizophrenia Research: Cognition, Volume 15Author(s): Elodie Peyroux, Zelda Prost, Charlotte Danset-Alexandre, Lindsay Brenugat-Herne, Isabelle Carteau-Martin, Baptiste Gaudelus, Célia Jantac, David Attali, Isabelle Amado, Jérôme Graux, Emmanuelle Houy-Durand, Julien Plasse, Nicolas FranckAbstractInteractions between social cognition and symptoms of schizophrenia have been investigated, but mostly component by component. Here we tested the assumption that two categories of deficits exist depending on clinical profiles, one corresponding to a defect in social cognitio...
Source: Schizophrenia Research: Cognition - November 9, 2018 Category: Psychiatry Source Type: research

Cognition in schizophrenia improves with treatment of severe obstructive sleep apnoea: A pilot study
Publication date: March 2019Source: Schizophrenia Research: Cognition, Volume 15Author(s): Hannah Myles, Nicholas Myles, Ching Li Chai Coetzer, Robert Adams, Madhu Chandratilleke, Dennis Liu, Jeremy Mercer, Andrew Vakulin, Andrew Vincent, Gary Wittert, Cherrie GalletlyAbstractPrevious studies have shown that people with schizophrenia have high rates of Obstructive Sleep Apnoea (OSA). Despite this, intervention studies to treat OSA in this population have not been undertaken. The ASSET (Assessing Sleep in Schizophrenia and Evaluating Treatment) pilot study investigated Continuous Positive Airway Pressure (CPAP) treatment of...
Source: Schizophrenia Research: Cognition - November 7, 2018 Category: Psychiatry Source Type: research

Association between lower estimated premorbid intelligence quotient and smoking behavior in patients with schizophrenia
Publication date: March 2019Source: Schizophrenia Research: Cognition, Volume 15Author(s): Shinsuke Hidese, Junko Matsuo, Ikki Ishida, Moeko Hiraishi, Toshiya Teraishi, Miho Ota, Kotaro Hattori, Hiroshi KunugiAbstractAimWe aimed to investigate the involvement of premorbid intelligence quotient in higher prevalence of smoking in patients with schizophrenia.MethodsParticipants included 190 patients with schizophrenia (mean ± standard deviation age: 37.7 ± 10.8 years; 88 males and 102 females) and 312 healthy individuals (mean ± standard deviation age: 38.1 ± 13.8; 166 males and 1...
Source: Schizophrenia Research: Cognition - October 9, 2018 Category: Psychiatry Source Type: research

The impact of schizophrenia and intelligence on the relationship between age and brain volume
This study points to effects of schizophrenia on GM early in the illness, before antipsychotic treatment is initiated, suggesting that WM changes may occur later in the disease process. (Source: Schizophrenia Research: Cognition)
Source: Schizophrenia Research: Cognition - October 5, 2018 Category: Psychiatry Source Type: research

Social functioning impairments in schizotypy when social cognition and neurocognition are not impaired
Publication date: December 2018Source: Schizophrenia Research: Cognition, Volume 14Author(s): Maral Aghvinian, Mark J. SergiAbstractThe present study examined the social, cognitive, and emotional functioning of persons with schizotypy. Over 2000 undergraduate students were screened for schizotypy with the Schizotypal Personality Questionnaire – Brief over two consecutive semesters. Ninety-two persons with high schizotypy and 22 persons with low schizotypy completed measures of social functioning (Social Adjustment Scale, Social Functioning Scale, MOS Social Support Survey), working memory (Paced Auditory Serial Addit...
Source: Schizophrenia Research: Cognition - August 24, 2018 Category: Psychiatry Source Type: research

Psychiatric symptoms and related dysfunction in a general population sample
Publication date: December 2018Source: Schizophrenia Research: Cognition, Volume 14Author(s): Lauren Smith, Abraham Reichenberg, Jonathan Rabinowitz, Stephen Z. Levine, Eva VelthorstAbstractBackgroundAlong with the key clinical features of major psychiatric disorders such as psychosis, mania, and depression, these disorders are also associated with cognitive, social, and functional deficits. A growing body of evidence suggests that these disorders exist at the extreme end of a continuum of symptoms rather than as binary entities, so it is plausible that the associated cognitive, social, and functional deficits assume a sim...
Source: Schizophrenia Research: Cognition - August 12, 2018 Category: Psychiatry Source Type: research

Superior memory performance in healthy individuals with subclinical psychotic symptoms but without genetic load for schizophrenia
Publication date: September 2018Source: Schizophrenia Research: Cognition, Volume 13Author(s): G. Gagnon, S. Kumar, J.-R. Maltais, A.N. Voineskos, B.H. Mulsant, T.K. Rajji (Source: Schizophrenia Research: Cognition)
Source: Schizophrenia Research: Cognition - August 5, 2018 Category: Psychiatry Source Type: research

Positive symptoms and time perception in schizophrenia: A meta-analysis
Publication date: September 2018Source: Schizophrenia Research: Cognition, Volume 13Author(s): Natsuki Ueda, Kazushi Maruo, Tomiki SumiyoshiAbstractPositive symptoms of schizophrenia may be related to distortions in time perception. To examine this issue, we conducted a meta-analysis to determine whether positive symptoms are associated with deficits in time processing performance. MEDLINE and Web of Science were searched from January 1980 through March 2017, and all related articles and their references were scrutinized to find relevant studies. Studies were selected if they included participants with a diagnosis of schiz...
Source: Schizophrenia Research: Cognition - August 3, 2018 Category: Psychiatry Source Type: research

The role of functional capacity in the prediction of occupational status in schizophrenia
Publication date: September 2018Source: Schizophrenia Research: Cognition, Volume 13Author(s): Lucas M. Mantovani, João V. Salgado (Source: Schizophrenia Research: Cognition)
Source: Schizophrenia Research: Cognition - July 11, 2018 Category: Psychiatry Source Type: research

Model selection and prediction of outcomes in recent onset schizophrenia patients who undergo cognitive training
Publication date: March 2018Source: Schizophrenia Research: Cognition, Volume 11Author(s): Ian S. Ramsay, Sisi Ma, Melissa Fisher, Rachel L. Loewy, J. Daniel Ragland, Tara Niendam, Cameron S. Carter, Sophia VinogradovAbstractPredicting treatment outcomes in psychiatric populations remains a challenge, but is increasingly important in the pursuit of personalized medicine. Patients with schizophrenia have deficits in cognition, and targeted cognitive training (TCT) of auditory processing and working memory has been shown to improve some of these impairments; but little is known about the baseline patient characteristics pred...
Source: Schizophrenia Research: Cognition - July 10, 2018 Category: Psychiatry Source Type: research

The influence of schizotypal traits on attention under high perceptual load
This article considers whether perceptual resource limitations play a role in moderating attentional abnormalities in SSD. According to perceptual load theory, perceptual resource limitations can lead to attenuated or superior performance on dual-task paradigms depending on whether participants are required to process, or attempt to ignore, secondary stimuli. If SSD is associated with perceptual resource limitations, and if it represents the extreme end of an otherwise normally distributed neuropsychological phenotype, schizotypal traits in the general population should lead to disproportionate performance costs on dual-ta...
Source: Schizophrenia Research: Cognition - July 10, 2018 Category: Psychiatry Source Type: research

Diminished Hedonic response in neuroleptic-free youth at ultra high-risk for psychosis
In this study, we examined neurophysiological and self-reported response to emotional stimuli in UHR (n = 23) and healthy control (CN: n = 30) participants who passively viewed pleasant, unpleasant, and neutral images for 500 ms while the electroencephalogram was recorded and then provided self-reports of valence and arousal to the stimuli. The Late Positive Potential (LPP) event related potential (ERP) component was used as a neurophysiological marker of emotional reactivity. Results indicated that CN participants had higher LPP amplitude for pleasant and unpleasant compared to neutral stimuli; ho...
Source: Schizophrenia Research: Cognition - July 10, 2018 Category: Psychiatry Source Type: research

Galantamine-memantine combination effective in dementia: Translate to dementia praecox?
Publication date: June 2018Source: Schizophrenia Research: Cognition, Volume 12Author(s): Maju Mathew Koola, Ajay K. Parsaik (Source: Schizophrenia Research: Cognition)
Source: Schizophrenia Research: Cognition - July 10, 2018 Category: Psychiatry Source Type: research

Polygenic signal for symptom dimensions and cognitive performance in patients with chronic schizophrenia
Publication date: June 2018Source: Schizophrenia Research: Cognition, Volume 12Author(s): Rose Mary Xavier, Jennifer R. Dungan, Richard S.E. Keefe, Allison VorderstrasseAbstractGenetic etiology of psychopathology symptoms and cognitive performance in schizophrenia is supported by candidate gene and polygenic risk score (PRS) association studies. Such associations are reported to be dependent on several factors - sample characteristics, illness phase, illness severity etc. We aimed to examine if schizophrenia PRS predicted psychopathology symptoms and cognitive performance in patients with chronic schizophrenia. We also exa...
Source: Schizophrenia Research: Cognition - July 10, 2018 Category: Psychiatry Source Type: research

Effects of transcranial direct current stimulation on working memory and negative symptoms in schizophrenia: a phase II randomized sham-controlled trial
Publication date: June 2018Source: Schizophrenia Research: Cognition, Volume 12Author(s): J.S. Gomes, A.P. Trevizol, D.V. Ducos, A. Gadelha, B.B. Ortiz, A.O. Fonseca, H.T. Akiba, C.C. Azevedo, L.S.P. Guimaraes, P. Shiozawa, Q. Cordeiro, A. Lacerda, A.M. DiasAbstractBackgroundThe lack of efficacy of pharmacological treatments for cognitive and negative symptoms in schizophrenia highlights the need for new interventions. We investigated the effects of tDCS on working memory and negative symptoms in patients with schizophrenia.MethodDouble-blinded, randomized, sham-controlled clinical trial, investigating the effects of 10 se...
Source: Schizophrenia Research: Cognition - July 10, 2018 Category: Psychiatry Source Type: research

Cognitive and psychopathology correlates of brain white/grey matter structure in severely psychotic schizophrenic inpatients
Publication date: June 2018Source: Schizophrenia Research: Cognition, Volume 12Author(s): Nerisa Banaj, Federica Piras, Fabrizio Piras, Valentina Ciullo, Mariangela Iorio, Claudia Battaglia, Donatella Pantoli, Giuseppe Ducci, Gianfranco SpallettaAbstractThe brain structural correlates of cognitive and psychopathological symptoms within the active phase in severely psychotic schizophrenic inpatients have been rarely investigated. Twenty-eight inpatients with a DSM-5 diagnosis of Schizophrenia (SZ), admitted for acute psychotic decompensation, were assessed through a comprehensive neuropsychological and psychopathological ba...
Source: Schizophrenia Research: Cognition - July 10, 2018 Category: Psychiatry Source Type: research

Speech-on-speech masking and psychotic symptoms in schizophrenia
This study investigated whether the TSR impairment in schizophrenia is associated with their impaired auditory working memory or certain psychotic symptoms. Thirty participants with schizophrenia (mean age = 35.2 ± 12.7 years) and 30 demographics-matched healthy controls (mean age = 32.9 ± 10.9 years) were tested for their TSR against a two-talker-speech masker. Auditory working memory and memory capacity were evaluated using the Paced Auditory Serial Addition Test (PASAT) and Digit Span Test. Psychotic symptoms were evaluated using the Positive and Negative Syndrome Scale (PANSS). The res...
Source: Schizophrenia Research: Cognition - July 10, 2018 Category: Psychiatry Source Type: research

Long-term treatment with clozapine and verbal memory performance in schizophrenia
Publication date: June 2018Source: Schizophrenia Research: Cognition, Volume 12Author(s): Letícia S. Czepielewski, Marina D.B. Londero, Mathias H. de Sousa, Carolina P. Perin, Helena C. Maldonado, Felipe C.A. Claudino, Clarissa S. GamaAbstractClozapine is more efficacious than first-generation antipsychotics for positive and negative symptoms, although it is related with serious adverse effects. Because of this profile, it could also have an impact on cognition. Therefore, we evaluated learning ability of 31 treatment-resistant individuals with SZ using clozapine uninterruptedly for 18.23 ± 4.71 years a...
Source: Schizophrenia Research: Cognition - July 10, 2018 Category: Psychiatry Source Type: research